Protein detail

UB2D4

Ubiquitin-conjugating enzyme E2 D4 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme D4) (HBUCE1) (Ubiquitin carrier protein D4) (Ubiquitin-protein ligase D4)

Entry name UB2D4	UniProt ID Q9Y2X8	EVMP score 0.38
Frequency 5	Transmembrane count	Protein classification EnzymesMetabolic proteinsPredicted intracellular proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Ubiquitin-conjugating enzyme E2 D4 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme D4) (HBUCE1) (Ubiquitin carrier protein D4) (Ubiquitin-protein ligase D4)

Protein Class

EnzymesMetabolic proteinsPredicted intracellular proteins

Protein Function

ENZYME proteins:Transferases
Enzymes
Predicted intracellular proteins

Ensembl

ENSG00000078967

Entrez Gene Symbol

UBE2D4

Gene Synonym

HBUCE1

Gene Description

Ubiquitin conjugating enzyme E2 D4 (putative)

Chromosome

Position

43926436-43956136

Frequency

EVMP Score

0.38

Fluorescence & Localization

Tissue Specificblood vesselCell SpecificBrain inhibitory neuronsSingle-Nuclei Brain Specificpericyte

Function & Pathway

Protein Function

ENZYME proteins:Transferases
Enzymes
Predicted intracellular proteins

Cellular Component

GO:0005634 nucleus

Molecular Function

Biological Process

KEGG

Reactome

Mediation Categories

Immune mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

3 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Regulatory Interaction Network

8 records.

Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
COMPLEX:A0AVT1_P0CG47	UB2D4	Q9Y2X8	Yes	Yes	No	SIGNOR	SIGNOR:34199813
COMPLEX:A0AVT1_P62979	UB2D4	Q9Y2X8	Yes	Yes	No	SIGNOR	SIGNOR:34199813
COMPLEX:A0AVT1_P0CG48	UB2D4	Q9Y2X8	Yes	Yes	No	SIGNOR	SIGNOR:34199813
COMPLEX:A0AVT1_P62987	UB2D4	Q9Y2X8	Yes	Yes	No	SIGNOR	SIGNOR:34199813
COMPLEX:P22314_P62979	UB2D4	Q9Y2X8	Yes	Yes	No	SIGNOR	SIGNOR:34199813
COMPLEX:P22314_P62987	UB2D4	Q9Y2X8	Yes	Yes	No	SIGNOR	SIGNOR:34199813
COMPLEX:P0CG47_P22314	UB2D4	Q9Y2X8	Yes	Yes	No	SIGNOR	SIGNOR:34199813
COMPLEX:P0CG48_P22314	UB2D4	Q9Y2X8	Yes	Yes	No	SIGNOR	SIGNOR:34199813

Protein Complex Composition

6 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
Ub:E2	UBB UBE2D4	P0CG47 Q9Y2X8	0:0	SIGNOR	SIGNOR:SIGNOR-C497
Ub:E2	UBC UBE2D4	P0CG48 Q9Y2X8	0:0	SIGNOR	SIGNOR:SIGNOR-C497
Ub:E2	RPS27A UBE2D4	P62979 Q9Y2X8	0:0	SIGNOR	SIGNOR:SIGNOR-C497
Ub:E2	UBA52 UBE2D4	P62987 Q9Y2X8	0:0	SIGNOR	SIGNOR:SIGNOR-C497
	ALDH1A2 IPO5 KPNB1 NUP153 NUP214 NUP98 NUTF2 RAN RANBP2 TNPO1 UBC UBE2D4 XPO1 XPOT	O00410 O14980 O43592 O94788 P0CG48 P35658 P49790 P49792 P52948 P61970 P62826 Q14974 Q92973 Q9Y2X8	1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC7166
	BTRC CUL1 FBXL12 FBXO33 FBXO42 FBXO5 RBX1 SKP1 UBE2D4 USP47	P62877 P63208 Q13616 Q6P3S6 Q7Z6M2 Q96K76 Q9NXK8 Q9UKT4 Q9Y297 Q9Y2X8	1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC8648

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
	Mass spectrometry	0

Sequence, Structure & Domains

Sequences

Length

147

Mass

16,649

Sequence

MALKRIQKELTDLQRDPPAQCSAGPVGDDLFHWQATIMGPNDSPYQGGVFFLTIHFPTDYPFKPPKVAFTTKIYHPNINSNGSICLDILRSQWSPALTVSKVLLSICSLLCDPNPDDPLVPEIAHTYKADREKYNRLAREWTQKYAM

3D Structural Models

Domain & Motif Annotations

Domain (FT)

1..147; UBC core

Protein Families

Ubiquitin-conjugating enzyme family

Sequence Similarities

Belongs to the ubiquitin-conjugating enzyme family.

Clinical Relevance

Antibody

HPA003920

Interaction Protein

ENSG00000013561ENSG00000022840ENSG00000070423ENSG00000080561ENSG00000091073ENSG00000101871ENSG00000121481ENSG00000123091ENSG00000138942ENSG00000146755ENSG00000157450ENSG00000158717ENSG00000159461ENSG00000163481ENSG00000165886ENSG00000167770ENSG00000168411ENSG00000168894ENSG00000171206ENSG00000178498ENSG00000186187ENSG00000204227ENSG00000204308ENSG00000204599ENSG00000265491

Interaction Count

Interaction Dataset

intact_biogridintact_biogrid_bioplex