Protein detail

ACOT9

Acyl-coenzyme A thioesterase 9, mitochondrial (Acyl-CoA thioesterase 9) (EC 3.1.2.-) (EC 3.1.2.2) (Acyl-CoA thioester hydrolase 9)

Protein symbol ACOT9	UniProt ID Q9Y305	EVMP score 0.50
Frequency 2	Transmembrane count	Protein classification Metabolic proteinsPredicted intracellular proteins

Basic Information

Protein Names

Acyl-coenzyme A thioesterase 9, mitochondrial (Acyl-CoA thioesterase 9) (EC 3.1.2.-) (EC 3.1.2.2) (Acyl-CoA thioester hydrolase 9)

Protein Class

Metabolic proteinsPredicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000123130

Entrez Gene Symbol

ACOT9

Gene Synonym

ACATE2CGI-16MT-ACT48

Gene Description

Acyl-CoA thioesterase 9

Chromosome

Position

23701055-23766475

Frequency

EVMP Score

0.50

Fluorescence & Localization

Tissue SpecificliverCell SpecificcDCSingle-Nuclei Brain SpecificfibroblastBlood Cell Specificclassical monocyteBlood Lineage Specificdendritic cells

Function & Pathway

Protein Function

Predicted intracellular proteins

Cellular Component

Molecular Function

Biological Process

Reactome

Canonical Pathways

M184 Pid ecadherin keratinocyte pathway
M210 Pid il8 cxcr2 pathway
M16801 Sig regulation of the actin cytoskeleton by rho gtpases

Mediation Categories

Metabolism mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

4 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Regulatory Interaction Network

0 records.

Protein Complex Composition

5 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
HT_DM_Cluster88	ACOT9 SAR1A SAR1B SOD2 ZC4H2	P04179 Q9NQZ6 Q9NR31 Q9Y305 Q9Y6B6	1:1:1:1:1	Compleat	Compleat:HC2528	22036573
	ACOT9 HIBCH NUDT19 SRI	A8MXV4 P30626 Q6NVY1 Q9Y305	0:0:0:0	hu.MAP2
	ACOT9 FAH HIBCH MACROD1	P16930 Q6NVY1 Q9BQ69 Q9Y305	0:0:0:0	hu.MAP
	ACOT9 FAH HIBCH	P16930 Q6NVY1 Q9Y305	0:0:0	hu.MAP
	ACOT9 CBR4 HSD17B8 MOCOS	Q8N4T8 Q92506 Q96EN8 Q9Y305	0:0:0:0	hu.MAP

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometryWestern blottingELISA	5	36064647 38113368 40465195 37322475 33592500

Sequence, Structure & Domains

Sequences

Length

439

Mass

49,902

Sequence

MRRAALRLCALGKGQLTPGRGLTQGPQNPKKQGIFHIHEVRDKLREIVGASTNWRDHVKAMEERKLLHSFLAKSQDGLPPRRMKDSYIEVLLPLGSEPELREKYLTVQNTVRFGRILEDLDSLGVLICYMHNKIHSAKMSPLSIVTALVDKIDMCKKSLSPEQDIKFSGHVSWVGKTSMEVKMQMFQLHGDEFCPVLDATFVMVARDSENKGPAFVNPLIPESPEEEELFRQGELNKGRRIAFSSTSLLKMAPSAEERTTIHEMFLSTLDPKTISFRSRVLPSNAVWMENSKLKSLEICHPQERNIFNRIFGGFLMRKAYELAWATACSFGGSRPFVVAVDDIMFQKPVEVGSLLFLSSQVCFTQNNYIQVRVHSEVASLQEKQHTTTNVFHFTFMSEKEVPLVFPKTYGESMLYLDGQRHFNSMSGPATLRKDYLVEP

Alternative Products

Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9Y305-1; Sequence=Displayed; Name=2; IsoId=Q9Y305-2; Sequence=VSP_036419; Name=3; IsoId=Q9Y305-3; Sequence=VSP_036420; Name=4; IsoId=Q9Y305-4; Sequence=VSP_041093

Alternative Sequence

1..60; Missing (in isoform 3); 5..39; ALRLCALGKGQLTPGRGLTQGPQNPKKQGIFHIHE -> PC (in isoform 2); 39; E -> EACSSIHVNH (in isoform 4)

3D Structural Models

Domain & Motif Annotations

Domain (FT)

84..209; HotDog ACOT-type 1; 289..401; HotDog ACOT-type 2

Protein Families

Acyl coenzyme A hydrolase family

Sequence Similarities

Belongs to the acyl coenzyme A hydrolase family.

Clinical Relevance

Antibody

HPA035533