Protein detail
VPP2
V-type proton ATPase 116 kDa subunit a 2 (V-ATPase 116 kDa subunit a 2) (Lysosomal H(+)-transporting ATPase V0 subunit a 2) (TJ6) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2)
Entry name VPP2 | UniProt ID | EVMP confidence score 0.63 |
Supporting publications (n) 8 | Transmembrane count 8 | Protein classification Disease related genesHuman disease related genesMetabolic proteinsPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
V-type proton ATPase 116 kDa subunit a 2 (V-ATPase 116 kDa subunit a 2) (Lysosomal H(+)-transporting ATPase V0 subunit a 2) (TJ6) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2)
Protein Class (6)
Disease related genesHuman disease related genesMetabolic proteinsPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins
Protein Function (3)
- Disease related genes
- Human disease related genes:Congenital malformations:Congenital malformations of skin
- Predicted intracellular proteins
Transmembrane
394..412; Helical; 415..431; Helical; 446..475; Helical; 550..569; Helical; 588..608; Helical; 652..671; Helical; 740..764; Helical; 786..824; Helical
Transmembrane Count
8
Ensembl
Entrez Gene Symbol
Gene Synonym (11)
a2a2VATP6a2ATP6N1DJ6B7RTFStv1TJ6TJ6MTJ6sVph1
Gene Description
ATPase H+ transporting V0 subunit a2
Chromosome
12
Position
123712353-123761755
Supporting publications (n)
8
EVMP confidence score
0.63
Fluorescence & Localization2
Tissue SpecificbrainCell SpecificCone photoreceptor cells
Function & Pathway7
Protein Function (3)
- Disease related genes
- Human disease related genes:Congenital malformations:Congenital malformations of skin
- Predicted intracellular proteins
Cellular Component (12)
- GO:0000139 Golgi membrane
- GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain
- GO:0001669 acrosomal vesicle
- GO:0005765 lysosomal membrane
- GO:0005886 plasma membrane
- GO:0005925 focal adhesion
- GO:0010008 endosome membrane
- GO:0016471 vacuolar proton-transporting V-type ATPase complex
- GO:0030670 phagocytic vesicle membrane
- GO:0033176 proton-transporting V-type ATPase complex
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Molecular Function (3)
Biological Process (3)
KEGG (11)
- hsa00190 Oxidative phosphorylation
- KEGG:hsa01100 Metabolic pathways
- KEGG:hsa04142 Lysosome biogenesis
- KEGG:hsa04145 Phagosome
- KEGG:hsa04721 Synaptic vesicle cycle
- KEGG:hsa04966 Collecting duct acid secretion
- KEGG:hsa05110 Vibrio cholerae infection
- KEGG:hsa05120 Epithelial cell signaling in Helicobacter pylori infection
- KEGG:hsa05152 Tuberculosis
- KEGG:hsa05165 Human papillomavirus infection
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Reactome (9)
- R-hsa-168249 innate immune system
- R-hsa-77387 insulin receptor recycling
- R-hsa-983712 ion channel transport
- R-hsa-917937 iron uptake and transport
- R-hsa-1222556 ros and rns production in phagocytes
- R-hsa-74752 signaling by insulin receptor
- R-hsa-9006934 signaling by receptor tyrosine kinases
- R-hsa-917977 transferrin endocytosis and recycling
- R-hsa-382551 transport of small molecules
Mediation Categories (4)
Adhesion and uptake mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence22
Ligand-Receptor Signaling (18)
18 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | Yes | No |
| intracellular | intracellular | ComPPI | No | No | No | Yes | No |
| intracellular | intracellular | GO_Intercell | No | No | No | Yes | No |
| intracellular | intracellular | UniProt_location | No | No | No | Yes | No |
| intracellular | intracellular | OmniPath | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | Yes | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | Yes | No |
| transmembrane | transmembrane | OmniPath | No | No | No | Yes | No |
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Protein Complex Composition (3)
3 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| HT_DM_Cluster40 | ATP6AP2ATP6V0A1ATP6V0A2ATP6V0A4ATP6V0D1ATP6V0D2ATP6V0E1ATP6V0E2AWAT1AWAT2DGAT2DGAT2L6KIAA2013MOGAT1MOGAT2MOGAT3TCIRG1VMA21 | O15342O75787P61421Q13488Q3SYC2Q3ZAQ7Q58HT5Q6E213Q6ZPD8Q86VF5Q8IYS2Q8N8Y2Q8NHE4Q93050Q96PD6Q96PD7Q9HBG4Q9Y487 | 1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1 | Compleat | Compleat:HC2997 | 22036573 |
| ATP6AP1ATP6AP2ATP6V0A1ATP6V0A2ATP6V0CATP6V0D1ATP6V0D2TCIRG1VMA12VMA21VMA22 | O75787P27449P61421Q13488Q15904Q3ZAQ7Q8N511Q8N8Y2Q93050Q96NT0Q9Y487 | 0:0:0:0:0:0:0:0:0:0:0 | hu.MAP2 | |||
| ATP6V0A1ATP6V0A2ATP6V0D1 | P61421Q93050Q9Y487 | 0:0:0 | hu.MAPhu.MAP2 |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyImmunoaffinity Capture | Mass spectrometry [LTQ-FT Ultra]Mass spectrometry | 29 | 3606464738113368404651953732247536497184401894973889596241068253335925003285431538014595325607233161715832916986413079683614683433309826408407013767004931805958386070623877265238207106345762463720451537438638392070473767004937926756 |
Sequence, Structure & Domains5
Sequences
Length
856
Mass
98,082
Sequence
MGSLFRSETMCLAQLFLQSGTAYECLSALGEKGLVQFRDLNQNVSSFQRKFVGEVKRCEELERILVYLVQEINRADIPLPEGEASPPAPPLKQVLEMQEQLQKLEVELREVTKNKEKLRKNLLELIEYTHMLRVTKTFVKRNVEFEPTYEEFPSLESDSLLDYSCMQRLGAKLGFVSGLINQGKVEAFEKMLWRVCKGYTIVSYAELDESLEDPETGEVIKWYVFLISFWGEQIGHKVKKICDCYHCHVYPYPNTAEERREIQEGLNTRIQDLYTVLHKTEDYLRQVLCKAAESVYSRVIQVKKMKAIYHMLNMCSFDVTNKCLIAEVWCPEADLQDLRRALEEGSRESGATIPSFMNIIPTKETPPTRIRTNKFTEGFQNIVDAYGVGSYREVNPALFTIITFPFLFAVMFGDFGHGFVMFLFALLLVLNENHPRLNQSQEIMRMFFNGRYILLLMGLFSVYTGLIYNDCFSKSVNLFGSGWNVSAMYSSSHPPAEHKKMVLWNDSVVRHNSILQLDPSIPGVFRGPYPLGIDPIWNLATNRLTFLNSFKMKMSVILGIIHMTFGVILGIFNHLHFRKKFNIYLVSIPELLFMLCIFGYLIFMIFYKWLVFSAETSRVAPSILIEFINMFLFPASKTSGLYTGQEYVQRVLLVVTALSVPVLFLGKPLFLLWLHNGRSCFGVNRSGYTLIRKDSEEEVSLLGSQDIEEGNHQVEDGCREMACEEFNFGEILMTQVIHSIEYCLGCISNTASYLRLWALSLAHAQLSDVLWAMLMRVGLRVDTTYGVLLLLPVIALFAVLTIFILLIMEGLSAFLHAIRLHWVEFQNKFYVGAGTKFVPFSFSLLSSKFNNDDSVA
Domain & Motif Annotations
Protein Families
V-ATPase 116 kDa subunit family
Sequence Similarities
Belongs to the V-ATPase 116 kDa subunit family.
Clinical Relevance4
Antibody
Interaction Protein (13)
ENSG00000071553ENSG00000110719ENSG00000117394ENSG00000128524ENSG00000136710ENSG00000141469ENSG00000147416ENSG00000149357ENSG00000159720ENSG00000160131ENSG00000182220ENSG00000185883ENSG00000244045
Interaction Count
13
Interaction Dataset (3)
biogrid_opencell_bioplexbiogrid_bioplexbiogrid_opencell
Supporting Publications8
| PMID | Title | Abstract |
|---|---|---|
| 33592500 | A Proteomic Approach to Understand the Clinical Significance of Acute Myeloid Leukemia-Derived Extracellular Vesicles Reflecting Essential Characteristics of Leukemia. | No abstract available |
| 36064647 | Systemic proteomics and miRNA profile analysis of exosomes derived from human pluripotent stem cells. | No abstract available |
| 37322475 | Comprehensive profiling of extracellular vesicles in uveitis and scleritis enables biomarker discovery and mechanism exploration. | No abstract available |
| 38113368 | In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum. | No abstract available |
| 39001700 | Optimized AF4 combined with density cushion ultracentrifugation enables profiling of high-purity human blood extracellular vesicles. | No abstract available |
| 40189497 | Small extracellular vesicle-based one-step high-throughput microfluidic platform for epithelial ovarian cancer diagnosis. | No abstract available |
| 40465195 | Extracellular vesicle proteomics uncovers energy metabolism, complement system, and endoplasmic reticulum stress response dysregulation postexercise in males with myalgic encephalomyelitis/chronic fatigue syndrome. | No abstract available |
| 40840701 | Multiomics analysis to evaluate the enrichment of extracellular vesicles from human plasma. | No abstract available |