Protein detail
MTCL1
Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2)
Protein symbol MTCL1 | UniProt ID | EVMP score 0.38 |
Frequency | Transmembrane count | Protein classification Plasma proteinsPredicted intracellular proteins |
Basic Information
Protein Names
Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2)
Protein Class
Plasma proteinsPredicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
CCDC165KIAA0802SOGA2
Gene Description
Microtubule crosslinking factor 1
Chromosome
18
Position
8705556-8832778
EVMP Score
0.38
Fluorescence & Localization
Tissue SpecificbrainCell SpecificBrain excitatory neuronsBlood Cell Specificmemory CD4 T-cellBlood Lineage SpecificT-cellsSecretome LocationSecreted in brainSecretome FunctionCell adhesion
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component
- GO:0000776 kinetochore
- GO:0000922 spindle pole
- GO:0005615 extracellular space
- GO:0005737 cytoplasm
- GO:0005856 cytoskeleton
- GO:0005876 spindle microtubule
- GO:0016324 apical plasma membrane
- GO:0016327 apicolateral plasma membrane
- GO:0016328 lateral plasma membrane
- GO:0030496 midbody
- GO:0097427 microtubule bundle
Molecular Function
Biological Process
Canonical Pathways
M115 Pid reg gr pathway
Mediation Categories
Fusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
10 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| ecm | ecm | MatrixDB | Yes | No | No | No | No |
| ecm | ecm | OmniPath | Yes | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| apical_cell_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| lateral_cell_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
3 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| BEND3DOCK6FAM13CMTCL1PDZRN3RBAKTRIOUSP34ZNF785 | A8K8V0O75962Q5T5X7Q70CQ2Q8NE31Q96HP0Q9NYW8Q9UPQ7Q9Y4B5 | 0:0:0:0:0:0:0:0:0 | hu.MAP2 | |||
| MTCL1MTCL2RNF41SAMHD1 | O94964Q9H4P4Q9Y3Z3Q9Y4B5 | 0:0:0:0 | hu.MAP | |||
| CLEC16AMTCL1RNF41TTC1 | Q2KHT3Q99614Q9H4P4Q9Y4B5 | 0:0:0:0 | hu.MAP |
Sequence, Structure & Domains
Sequences
Length
1,905
Mass
209,526
Sequence
METLNGPAGGGAPDAKLQPPGQHHRHHHLHPVAERRRLHRAPSPARPFLKDLHARPAAPGPAVPSSGRAPAPAAPRSPNLAGKAPPSPGSLAAPGRLSRRSGGVPGAKDKPPPGAGARAAGGAKAALGSRRAARVAPAEPLSRAGKPPGAEPPSAAAKGRKAKRGSRAPPARTVGPPTPAARIPAVTLAVTSVAGSPARCSRISHTDSSSDLSDCPSEPLSDEQRLLPAASSDAESGTGSSDREPPRGAPTPSPAARGAPPGSPEPPALLAAPLAAGACPGGRSIPSGVSGGFAGPGVAEDVRGRSPPERPVPGTPKEPSLGEQSRLVPAAEEEELLREMEELRSENDYLKDELDELRAEMEEMRDSYLEEDVYQLQELRRELDRANKNCRILQYRLRKAEQKSLKVAETGQVDGELIRSLEQDLKVAKDVSVRLHHELKTVEEKRAKAEDENETLRQQMIEVEISKQALQNELERLKESSLKRRSTREMYKEKKTFNQDDSADLRCQLQFAKEEAFLMRKKMAKLGREKDELEQELQKYKSLYGDVDSPLPTGEAGGPPSTREAELKLRLKLVEEEANILGRKIVELEVENRGLKAEMEDMRGQQEREGPGRDHAPSIPTSPFGDSLESSTELRRHLQFVEEEAELLRRSISEIEDHNRQLTHELSKFKFEPPREPGWLGEGASPGAGGGAPLQEELKSARLQISELSGKVLKLQHENHALLSNIQRCDLAAHLGLRAPSPRDSDAESDAGKKESDGEESRLPQPKREGPVGGESDSEEMFEKTSGFGSGKPSEASEPCPTELLKAREDSEYLVTLKHEAQRLERTVERLITDTDSFLHDAGLRGGAPLPGPGLQGEEEQGEGDQQEPQLLGTINAKMKAFKKELQAFLEQVNRIGDGLSPLPHLTESSSFLSTVTSVSRDSPIGNLGKELGPDLQSRLKEQLEWQLGPARGDERESLRLRAARELHRRADGDTGSHGLGGQTCFSLEMEEEHLYALRWKELEMHSLALQNTLHERTWSDEKNLMQQELRSLKQNIFLFYVKLRWLLKHWRQGKQMEEEGEEFTEGEHPETLSRLGELGVQGGHQADGPDHDSDRGCGFPVGEHSPHSRVQIGDHSLRLQTADRGQPHKQVVENQQLFSAFKALLEDFRAELREDERARLRLQQQYASDKAAWDVEWAVLKCRLEQLEEKTENKLGELGSSAESKGALKKEREVHQKLLADSHSLVMDLRWQIHHSEKNWNREKVELLDRLDRDRQEWERQKKEFLWRIEQLQKENSPRRGGSFLCDQKDGNVRPFPHQGSLRMPRPVAMWPCADADSIPFEDRPLSKLKESDRCSASENLYLDALSLDDEPEEPPAHRPEREFRNRLPEEEENHKGNLQRAVSVSSMSEFQRLMDISPFLPEKGLPSTSSKEDVTPPLSPDDLKYIEEFNKSWDYTPNRGHNGGGPDLWADRTEVGRAGHEDSTEPFPDSSWYLTTSVTMTTDTMTSPEHCQKQPLRSHVLTEQSGLRVLHSPPAVRRVDSITAAGGEGPFPTSRARGSPGDTKGGPPEPMLSRWPCTSPRHSRDYVEGARRPLDSPLCTSLGFASPLHSLEMSKNLSDDMKEVAFSVRNAICSGPGELQVKDMACQTNGSRTMGTQTVQTISVGLQTEALRGSGVTSSPHKCLTPKAGGGATPVSSPSRSLRSRQVAPAIEKVQAKFERTCCSPKYGSPKLQRKPLPKADQPNNRTSPGMAQKGYSESAWARSTTTRESPVHTTINDGLSSLFNIIDHSPVVQDPFQKGLRAGSRSRSAEPRPELGPGQETGTNSRGRSPSPIGVGSEMCREEGGEGTPVKQDLSAPPGYTLTENVARILNKKLLEHALKEERRQAAHGPPGLHSDSHSLGDTAEPGPMENQTVLLTAPWGL
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9Y4B5-1; Sequence=Displayed; Name=2; IsoId=Q9Y4B5-2; Sequence=VSP_023550; Name=3; IsoId=Q9Y4B5-3; Sequence=VSP_023550, VSP_023551; Name=4; IsoId=Q9Y4B5-4; Sequence=VSP_023549, VSP_023552, VSP_023553, VSP_023554
Alternative Sequence
1..1004; Missing (in isoform 4); 1..360; Missing (in isoform 2 and isoform 3); 989; E -> ELRGPPVLPEQSVSIEELQGQLVQAARLHQEETETFTNKIHK (in isoform 3); 1187; Q -> QNCCGYPRINIEEETLGFTRLPAGSTVKTLKSLGLQRLE (in isoform 4); 1273..1300; Missing (in isoform 4); 1894..1905; NQTVLLTAPWGL -> ELPCSALAPSLEPCFSRPERPANRRPPSRWAPHSPTASQPQSPGDPTSLEEHGGEEPPEEQPHRDASLHGLSQYNSL (in isoform 4)
3D Structural Models
Domain & Motif Annotations
Compositional Bias
22..40; Basic residues; 63..95; Low complexity; 115..130; Low complexity; 268..283; Low complexity; 601..616; Basic and acidic residues; 680..692; Gly residues; 741..770; Basic and acidic residues; 857..866; Acidic residues; 1356..1377; Basic and acidic residues; 1678..1687; Low complexity; 1744..1756; Polar residues
Coiled Coil
330..404; 432..483; 513..718; 1143..1201; 1238..1278
Region
1..508; Necessary for self-assembly, microtubule bundling activity and apicobasal microtubule organization; 1..329; Disordered; 1..249; Necessary for colocalization and binding with microtubules; 544..563; Disordered; 601..631; Disordered; 671..694; Disordered; 737..800; Disordered; 842..867; Disordered; 1080..1100; Disordered; 1265..1382; Necessary for interaction with MARK2 and apicobasal microtubule bundle formation in polarized epithelial cells; 1346..1384; Disordered; 1485..1505; Disordered; 1524..1569; Disordered; 1655..1689; Disordered; 1678..1773; Necessary for colocalization and binding with microtubules; 1707..1756; Disordered; 1782..1842; Disordered; 1863..1905; Disordered
Protein Families
SOGA family
Sequence Similarities
Belongs to the SOGA family.
Clinical Relevance
Antibody
Interaction Protein
ENSG00000072518ENSG00000077549ENSG00000088986
Interaction Count
3
Interaction Dataset
intact_biogridbiogrid_opencell