Protein detail

MTCL1

Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2)

Entry name MTCL1	UniProt ID Q9Y4B5	EVMP confidence score 0.38
Supporting publications (n)	Transmembrane count	Protein classification Plasma proteinsPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information10

Protein Names

Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2)

Protein Class (2)

Plasma proteinsPredicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000168502

Entrez Gene Symbol

MTCL1

Gene Synonym (3)

CCDC165KIAA0802SOGA2

Gene Description

Microtubule crosslinking factor 1

Chromosome

Position

8705556-8832778

EVMP confidence score

0.38

Fluorescence & Localization6

Tissue SpecificbrainCell SpecificBrain excitatory neuronsBlood Cell Specificmemory CD4 T-cellBlood Lineage SpecificT-cellsSecretome LocationSecreted in brainSecretome FunctionCell adhesion

Function & Pathway6

Protein Function

Predicted intracellular proteins

Cellular Component (11)

Page 1 of 2

Molecular Function (4)

Biological Process (3)

Canonical Pathways

M115 Pid reg gr pathway

Mediation Categories

Fusion and delivery mediation

Relations & Evidence14

Ligand-Receptor Signaling (10)

10 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
ecm	ecm	MatrixDB	Yes	No	No	No	No
ecm	ecm	OmniPath	Yes	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
apical_cell_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
lateral_cell_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No

Protein Complex Composition (3)

3 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database
BEND3 DOCK6 FAM13C MTCL1 PDZRN3 RBAK TRIO USP34 ZNF785	A8K8V0 O75962 Q5T5X7 Q70CQ2 Q8NE31 Q96HP0 Q9NYW8 Q9UPQ7 Q9Y4B5	0:0:0:0:0:0:0:0:0	hu.MAP2
MTCL1 MTCL2 RNF41 SAMHD1	O94964 Q9H4P4 Q9Y3Z3 Q9Y4B5	0:0:0:0	hu.MAP
CLEC16A MTCL1 RNF41 TTC1	Q2KHT3 Q99614 Q9H4P4 Q9Y4B5	0:0:0:0	hu.MAP

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometry	9	36064647 38113368 40465195 37322475 38354507 41068253 33592500 40840701 32230970

Sequence, Structure & Domains10

Sequences

Length

1,905

Mass

209,526

Sequence

METLNGPAGGGAPDAKLQPPGQHHRHHHLHPVAERRRLHRAPSPARPFLKDLHARPAAPGPAVPSSGRAPAPAAPRSPNLAGKAPPSPGSLAAPGRLSRRSGGVPGAKDKPPPGAGARAAGGAKAALGSRRAARVAPAEPLSRAGKPPGAEPPSAAAKGRKAKRGSRAPPARTVGPPTPAARIPAVTLAVTSVAGSPARCSRISHTDSSSDLSDCPSEPLSDEQRLLPAASSDAESGTGSSDREPPRGAPTPSPAARGAPPGSPEPPALLAAPLAAGACPGGRSIPSGVSGGFAGPGVAEDVRGRSPPERPVPGTPKEPSLGEQSRLVPAAEEEELLREMEELRSENDYLKDELDELRAEMEEMRDSYLEEDVYQLQELRRELDRANKNCRILQYRLRKAEQKSLKVAETGQVDGELIRSLEQDLKVAKDVSVRLHHELKTVEEKRAKAEDENETLRQQMIEVEISKQALQNELERLKESSLKRRSTREMYKEKKTFNQDDSADLRCQLQFAKEEAFLMRKKMAKLGREKDELEQELQKYKSLYGDVDSPLPTGEAGGPPSTREAELKLRLKLVEEEANILGRKIVELEVENRGLKAEMEDMRGQQEREGPGRDHAPSIPTSPFGDSLESSTELRRHLQFVEEEAELLRRSISEIEDHNRQLTHELSKFKFEPPREPGWLGEGASPGAGGGAPLQEELKSARLQISELSGKVLKLQHENHALLSNIQRCDLAAHLGLRAPSPRDSDAESDAGKKESDGEESRLPQPKREGPVGGESDSEEMFEKTSGFGSGKPSEASEPCPTELLKAREDSEYLVTLKHEAQRLERTVERLITDTDSFLHDAGLRGGAPLPGPGLQGEEEQGEGDQQEPQLLGTINAKMKAFKKELQAFLEQVNRIGDGLSPLPHLTESSSFLSTVTSVSRDSPIGNLGKELGPDLQSRLKEQLEWQLGPARGDERESLRLRAARELHRRADGDTGSHGLGGQTCFSLEMEEEHLYALRWKELEMHSLALQNTLHERTWSDEKNLMQQELRSLKQNIFLFYVKLRWLLKHWRQGKQMEEEGEEFTEGEHPETLSRLGELGVQGGHQADGPDHDSDRGCGFPVGEHSPHSRVQIGDHSLRLQTADRGQPHKQVVENQQLFSAFKALLEDFRAELREDERARLRLQQQYASDKAAWDVEWAVLKCRLEQLEEKTENKLGELGSSAESKGALKKEREVHQKLLADSHSLVMDLRWQIHHSEKNWNREKVELLDRLDRDRQEWERQKKEFLWRIEQLQKENSPRRGGSFLCDQKDGNVRPFPHQGSLRMPRPVAMWPCADADSIPFEDRPLSKLKESDRCSASENLYLDALSLDDEPEEPPAHRPEREFRNRLPEEEENHKGNLQRAVSVSSMSEFQRLMDISPFLPEKGLPSTSSKEDVTPPLSPDDLKYIEEFNKSWDYTPNRGHNGGGPDLWADRTEVGRAGHEDSTEPFPDSSWYLTTSVTMTTDTMTSPEHCQKQPLRSHVLTEQSGLRVLHSPPAVRRVDSITAAGGEGPFPTSRARGSPGDTKGGPPEPMLSRWPCTSPRHSRDYVEGARRPLDSPLCTSLGFASPLHSLEMSKNLSDDMKEVAFSVRNAICSGPGELQVKDMACQTNGSRTMGTQTVQTISVGLQTEALRGSGVTSSPHKCLTPKAGGGATPVSSPSRSLRSRQVAPAIEKVQAKFERTCCSPKYGSPKLQRKPLPKADQPNNRTSPGMAQKGYSESAWARSTTTRESPVHTTINDGLSSLFNIIDHSPVVQDPFQKGLRAGSRSRSAEPRPELGPGQETGTNSRGRSPSPIGVGSEMCREEGGEGTPVKQDLSAPPGYTLTENVARILNKKLLEHALKEERRQAAHGPPGLHSDSHSLGDTAEPGPMENQTVLLTAPWGL

Alternative Products

Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9Y4B5-1; Sequence=Displayed; Name=2; IsoId=Q9Y4B5-2; Sequence=VSP_023550; Name=3; IsoId=Q9Y4B5-3; Sequence=VSP_023550, VSP_023551; Name=4; IsoId=Q9Y4B5-4; Sequence=VSP_023549, VSP_023552, VSP_023553, VSP_023554

Alternative Sequence

1..1004; Missing (in isoform 4); 1..360; Missing (in isoform 2 and isoform 3); 989; E -> ELRGPPVLPEQSVSIEELQGQLVQAARLHQEETETFTNKIHK (in isoform 3); 1187; Q -> QNCCGYPRINIEEETLGFTRLPAGSTVKTLKSLGLQRLE (in isoform 4); 1273..1300; Missing (in isoform 4); 1894..1905; NQTVLLTAPWGL -> ELPCSALAPSLEPCFSRPERPANRRPPSRWAPHSPTASQPQSPGDPTSLEEHGGEEPPEEQPHRDASLHGLSQYNSL (in isoform 4)

Domain & Motif Annotations

Compositional Bias

22..40; Basic residues; 63..95; Low complexity; 115..130; Low complexity; 268..283; Low complexity; 601..616; Basic and acidic residues; 680..692; Gly residues; 741..770; Basic and acidic residues; 857..866; Acidic residues; 1356..1377; Basic and acidic residues; 1678..1687; Low complexity; 1744..1756; Polar residues

Coiled Coil

330..404; 432..483; 513..718; 1143..1201; 1238..1278

Region

1..508; Necessary for self-assembly, microtubule bundling activity and apicobasal microtubule organization; 1..329; Disordered; 1..249; Necessary for colocalization and binding with microtubules; 544..563; Disordered; 601..631; Disordered; 671..694; Disordered; 737..800; Disordered; 842..867; Disordered; 1080..1100; Disordered; 1265..1382; Necessary for interaction with MARK2 and apicobasal microtubule bundle formation in polarized epithelial cells; 1346..1384; Disordered; 1485..1505; Disordered; 1524..1569; Disordered; 1655..1689; Disordered; 1678..1773; Necessary for colocalization and binding with microtubules; 1707..1756; Disordered; 1782..1842; Disordered; 1863..1905; Disordered

Protein Families

SOGA family

Sequence Similarities

Belongs to the SOGA family.

Clinical Relevance4

Antibody

HPA046245

Interaction Protein (3)

ENSG00000072518ENSG00000077549ENSG00000088986

Interaction Count

Interaction Dataset (2)

intact_biogridbiogrid_opencell