Protein detail

RN114

E3 ubiquitin-protein ligase RNF114 (EC 2.3.2.27) (RING finger protein 114) (RING-type E3 ubiquitin transferase RNF114) (Zinc finger protein 228) (Zinc finger protein 313)

Protein symbol RN114	UniProt ID Q9Y508	EVMP score 0.38
Frequency 1	Transmembrane count	Protein classification EnzymesPredicted intracellular proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

E3 ubiquitin-protein ligase RNF114 (EC 2.3.2.27) (RING finger protein 114) (RING-type E3 ubiquitin transferase RNF114) (Zinc finger protein 228) (Zinc finger protein 313)

Protein Class

EnzymesPredicted intracellular proteins

Protein Function

ENZYME proteins:Transferases
Enzymes
Predicted intracellular proteins

Ensembl

ENSG00000124226

Entrez Gene Symbol

RNF114

Gene Synonym

PSORS12ZNF313

Gene Description

Ring finger protein 114

Chromosome

Position

49936336-49953885

Frequency

EVMP Score

0.38

Fluorescence & Localization

Function & Pathway

Protein Function

ENZYME proteins:Transferases
Enzymes
Predicted intracellular proteins

Cellular Component

Molecular Function

Biological Process

Reactome

Canonical Pathways

M86 Pid arf6 pathway
M141 Pid pi3kci pathway

Mediation Categories

Immune mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

5 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Regulatory Interaction Network

136 records.

Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
COMPLEX:P62987_Q7Z7E8	RN114	Q9Y508	Yes	Yes	No	SIGNOR	SIGNOR:34199813
COMPLEX:P0CG48_P61081	RN114	Q9Y508	Yes	Yes	No	SIGNOR	SIGNOR:34199813
COMPLEX:P62979_Q9Y385	RN114	Q9Y508	Yes	Yes	No	SIGNOR	SIGNOR:34199813
COMPLEX:P0CG48_P51965	RN114	Q9Y508	Yes	Yes	No	SIGNOR	SIGNOR:34199813
COMPLEX:P62987_Q96LR5	RN114	Q9Y508	Yes	Yes	No	SIGNOR	SIGNOR:34199813
COMPLEX:P0CG48_Q8WVN8	RN114	Q9Y508	Yes	Yes	No	SIGNOR	SIGNOR:34199813
COMPLEX:P51668_P62979	RN114	Q9Y508	Yes	Yes	No	SIGNOR	SIGNOR:34199813
COMPLEX:P60604_P62987	RN114	Q9Y508	Yes	Yes	No	SIGNOR	SIGNOR:34199813
COMPLEX:P0CG48_P61086	RN114	Q9Y508	Yes	Yes	No	SIGNOR	SIGNOR:34199813
COMPLEX:P62987_Q5JXB2	RN114	Q9Y508	Yes	Yes	No	SIGNOR	SIGNOR:34199813

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Protein Complex Composition

4 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
Ub:RING_E3	RNF114 UBB	P0CG47 Q9Y508	0:0	SIGNOR	SIGNOR:SIGNOR-C519
Ub:RING_E3	RNF114 UBC	P0CG48 Q9Y508	0:0	SIGNOR	SIGNOR:SIGNOR-C519
Ub:RING_E3	RNF114 RPS27A	P62979 Q9Y508	0:0	SIGNOR	SIGNOR:SIGNOR-C519
Ub:RING_E3	RNF114 UBA52	P62987 Q9Y508	0:0	SIGNOR	SIGNOR:SIGNOR-C519

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	3	40596376 38037300 40689422

Sequence, Structure & Domains

Sequences

Length

228

Mass

25,694

Sequence

MAAQQRDCGGAAQLAGPAAEADPLGRFTCPVCLEVYEKPVQVPCGHVFCSACLQECLKPKKPVCGVCRSALAPGVRAVELERQIESTETSCHGCRKNFFLSKIRSHVATCSKYQNYIMEGVKATIKDASLQPRNVPNRYTFPCPYCPEKNFDQEGLVEHCKLFHSTDTKSVVCPICASMPWGDPNYRSANFREHIQRRHRFSYDTFVDYDVDEEDMMNQVLQRSIIDQ

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9Y508-1; Sequence=Displayed; Name=2; IsoId=Q9Y508-2; Sequence=VSP_036843, VSP_036844

Alternative Sequence

173..191; CPICASMPWGDPNYRSANF -> SEQSPCLLSVSCYRASITY (in isoform 2); 192..228; Missing (in isoform 2)

3D Structural Models

Domain & Motif Annotations

Zinc Finger

29..68; RING-type; 91..110; C2HC RNF-type

Clinical Relevance

Antibody

HPA021184

Interaction Protein

ENSG00000072401ENSG00000131508ENSG00000132530

Interaction Count

Interaction Dataset

intact_biogrid