Protein detail

LRP12

Low-density lipoprotein receptor-related protein 12 (LDLR-related protein 12) (LRP-12) (Suppressor of tumorigenicity 7 protein)

Entry name LRP12	UniProt ID Q9Y561	EVMP confidence score 0.50
Supporting publications (n) 2	Transmembrane count 1	Protein classification Disease related genesHuman disease related genesPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Low-density lipoprotein receptor-related protein 12 (LDLR-related protein 12) (LRP-12) (Suppressor of tumorigenicity 7 protein)

Protein Class (3)

Disease related genesHuman disease related genesPredicted membrane proteins

Protein Function (2)

Disease related genes
Human disease related genes:Musculoskeletal diseases:Muscular diseases

Transmembrane

493..513; Helical

Transmembrane Count

Ensembl

ENSG00000147650

Entrez Gene Symbol

LRP12

Gene Synonym (2)

FLJ12929ST7

Gene Description

LDL receptor related protein 12

Chromosome

Position

104489231-104589258

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization3

Cell SpecificEarly spermatidsBlood Cell Specificbasophil

Function & Pathway6

Protein Function (2)

Disease related genes
Human disease related genes:Musculoskeletal diseases:Muscular diseases

Cellular Component (3)

Molecular Function (2)

Biological Process (3)

Reactome (4)

Mediation Categories

Metabolism mediation

Relations & Evidence36

Ligand-Receptor Signaling (35)

35 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	HPMR	No	Yes	No	Yes	No
receptor	receptor	Surfaceome	No	Yes	No	Yes	No
low_density_lipoprotein	receptor	Almen2009	No	Yes	No	Yes	No
low_density_lipoprotein_ldl_receptor_and_ldl_receptor_related_proteins	receptor	HPMR	No	Yes	No	Yes	No
ldlr	receptor	Surfaceome	No	Yes	No	Yes	No
receptor	receptor	OmniPath	No	Yes	No	Yes	No
extracellular	extracellular	HPMR	No	No	No	Yes	No
extracellular	extracellular	OmniPath	No	No	No	Yes	No
intracellular	intracellular	ComPPI	No	No	No	Yes	No
intracellular	intracellular	OmniPath	No	No	No	Yes	No

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometryWestern blottingELISA	8	36064647 38113368 40465195 37322475 40189497 33592500 40840701 39001700

Sequence, Structure & Domains10

Sequences

Length

859

Mass

94,984

Sequence

MACRWSTKESPRWRSALLLLFLAGVYGNGALAEHSENVHISGVSTACGETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETYKNIESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETNCTMCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNCFFCQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENCPVIVPTRVITAAVIGSLICGLLLVIALGCTCKLYSLRMFERRSFETQLSRVEAELLRREAPPSYGQLIAQGLIPPVEDFPVCSPNQASVLENLRLAVRSQLGFTSVRLPMAGRSSNIWNRIFNFARSRHSGSLALVSADGDEVVPSQSTSREPERNHTHRSLFSVESDDTDTENERRDMAGASGGVAAPLPQKVPPTTAVEATVGACASSSTQSTRGGHADNGRDVTSVEPPSVSPARHQLTSALSRMTQGLRWVRFTLGRSSSLSQNQSPLRQLDNGVSGREDDDDVEMLIPISDGSSDFDVNDCSRPLLDLASDQGQGLRQPYNATNPGVRPSNRDGPCERCGIVHTAQIPDTCLEVTLKNETSDDEALLLC

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9Y561-1; Sequence=Displayed; Name=2; IsoId=Q9Y561-2; Sequence=VSP_040992

Alternative Sequence

27..45; Missing (in isoform 2)

Domain & Motif Annotations

Compositional Bias

748..757; Polar residues; 801..814; Polar residues

Domain (FT)

47..159; CUB 1; 165..201; LDL-receptor class A 1; 214..255; LDL-receptor class A 2; 259..372; CUB 2; 374..411; LDL-receptor class A 3; 412..449; LDL-receptor class A 4; 450..486; LDL-receptor class A 5

Region

623..678; Disordered; 693..723; Disordered; 748..770; Disordered; 801..823; Disordered

Protein Families

LDLR family

Sequence Similarities

Belongs to the LDLR family.

Clinical Relevance2

Disease Involvement (2)

Amyotrophic lateral sclerosisNeurodegeneration

Antibody

HPA017245

Supporting Publications2

PMID	Title	Abstract
38731868	The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer.	No abstract available
40098346	Toward Identification of Markers for Brain-Derived Extracellular Vesicles in Cerebrospinal Fluid: A Large-Scale, Unbiased Analysis Using Proximity Extension Assays.	No abstract available