Protein detail

LRP12

Low-density lipoprotein receptor-related protein 12 (LDLR-related protein 12) (LRP-12) (Suppressor of tumorigenicity 7 protein)

Protein symbol LRP12	UniProt ID Q9Y561	EVMP score 0.50
Frequency 2	Transmembrane count 1	Protein classification Disease related genesHuman disease related genesPredicted membrane proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Low-density lipoprotein receptor-related protein 12 (LDLR-related protein 12) (LRP-12) (Suppressor of tumorigenicity 7 protein)

Protein Class

Disease related genesHuman disease related genesPredicted membrane proteins

Protein Function

Disease related genes
Human disease related genes:Musculoskeletal diseases:Muscular diseases

Transmembrane

493..513; Helical

Transmembrane Count

Ensembl

ENSG00000147650

Entrez Gene Symbol

LRP12

Gene Synonym

FLJ12929ST7

Gene Description

LDL receptor related protein 12

Chromosome

Position

104489231-104589258

Frequency

EVMP Score

0.50

Fluorescence & Localization

Cell SpecificEarly spermatidsBlood Cell Specificbasophil

Function & Pathway

Protein Function

Disease related genes
Human disease related genes:Musculoskeletal diseases:Muscular diseases

Cellular Component

Molecular Function

Biological Process

Reactome

Mediation Categories

Metabolism mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

35 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
plasma_membrane	plasma_membrane	Cellinker	No	No	No	Yes	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	Membranome	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	CSPA	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	HPMR	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	OmniPath	No	No	No	Yes	No
cell_surface	cell_surface	Surfaceome	No	No	No	Yes	No
cell_surface	cell_surface	OmniPath	No	No	No	Yes	No
receptor	receptor	Almen2009	No	Yes	No	Yes	No
receptor	receptor	CellCellInteractions	No	Yes	No	Yes	No

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Regulatory Interaction Network

0 records.

Protein Complex Composition

0 records.

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometryWestern blottingELISA	8	36064647 38113368 40465195 37322475 40189497 33592500 40840701 39001700

Sequence, Structure & Domains

Sequences

Length

859

Mass

94,984

Sequence

MACRWSTKESPRWRSALLLLFLAGVYGNGALAEHSENVHISGVSTACGETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETYKNIESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETNCTMCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNCFFCQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENCPVIVPTRVITAAVIGSLICGLLLVIALGCTCKLYSLRMFERRSFETQLSRVEAELLRREAPPSYGQLIAQGLIPPVEDFPVCSPNQASVLENLRLAVRSQLGFTSVRLPMAGRSSNIWNRIFNFARSRHSGSLALVSADGDEVVPSQSTSREPERNHTHRSLFSVESDDTDTENERRDMAGASGGVAAPLPQKVPPTTAVEATVGACASSSTQSTRGGHADNGRDVTSVEPPSVSPARHQLTSALSRMTQGLRWVRFTLGRSSSLSQNQSPLRQLDNGVSGREDDDDVEMLIPISDGSSDFDVNDCSRPLLDLASDQGQGLRQPYNATNPGVRPSNRDGPCERCGIVHTAQIPDTCLEVTLKNETSDDEALLLC

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9Y561-1; Sequence=Displayed; Name=2; IsoId=Q9Y561-2; Sequence=VSP_040992

Alternative Sequence

27..45; Missing (in isoform 2)

3D Structural Models

Domain & Motif Annotations

Compositional Bias

748..757; Polar residues; 801..814; Polar residues

Domain (FT)

47..159; CUB 1; 165..201; LDL-receptor class A 1; 214..255; LDL-receptor class A 2; 259..372; CUB 2; 374..411; LDL-receptor class A 3; 412..449; LDL-receptor class A 4; 450..486; LDL-receptor class A 5

Region

623..678; Disordered; 693..723; Disordered; 748..770; Disordered; 801..823; Disordered

Protein Families

LDLR family

Sequence Similarities

Belongs to the LDLR family.

Clinical Relevance

Disease Involvement

Amyotrophic lateral sclerosisNeurodegeneration

Antibody

HPA017245