Protein detail

PCDBB

Protocadherin beta-11 (PCDH-beta-11)

Entry name PCDBB	UniProt ID Q9Y5F2	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count 1	Protein classification Predicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information12

Protein Names

Protocadherin beta-11 (PCDH-beta-11)

Protein Class

Predicted membrane proteins

Transmembrane

691..711; Helical

Transmembrane Count

Ensembl

ENSG00000197479

Entrez Gene Symbol

PCDHB11

Gene Synonym (2)

ME2PCDH-BETA11

Gene Description

Protocadherin beta 11

Chromosome

Position

141199610-141203779

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization1

Cell SpecificCardiomyocytes

Function & Pathway6

Cellular Component (3)

Molecular Function

GO:0005509 calcium ion binding

Biological Process (3)

KEGG

hsa04519 Cadherin signaling

Canonical Pathways (3)

M156 Pid ecadherin nascent aj pathway
M278 Pid rac1 pathway
M164 Pid erbb1 downstream pathway

Mediation Categories

Adhesion and uptake mediation

Relations & Evidence30

Ligand-Receptor Signaling (29)

29 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	CellChatDB	No	Yes	No	Yes	No
receptor	receptor	OmniPath	No	Yes	No	Yes	No
extracellular	extracellular	OmniPath	No	No	No	Yes	No
cell_surface_ligand	cell_surface_ligand	CellChatDB	Yes	No	No	Yes	No
cell_surface_ligand	cell_surface_ligand	OmniPath	Yes	No	No	Yes	No
protocadherin	cell_adhesion	HGNC	Yes	Yes	No	Yes	No
adhesion	adhesion	HGNC	Yes	Yes	No	Yes	No
cell_adhesion	cell_adhesion	Zhong2015	Yes	Yes	No	Yes	No
icam	cell_adhesion	Zhong2015	Yes	Yes	No	Yes	No
beta_protocadherin	cell_adhesion	Almen2009	Yes	Yes	No	Yes	No

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Western blotting	2	40098346 37922300

Sequence, Structure & Domains6

Sequences

Length

797

Mass

87,088

Sequence

MENQGTRTQQIRQVLLLFVLLGMSQAGSETWSFSVAEEMQSGSFVGNLAKDLGLKVRELSSRGARVVSNDKKQRLQLDINTGDLLLSETLDREELCGSIEPCVLHLQVLMQNPTQFLQIELQVRDINDHSPIFSEKQMLLEIPENSPVGAVFLLESAKDLDVGINAVKSYTISPNSHFHIKMRVIPDNRKYPELVLDKALDYEELPELSFILSALDGGSPPRSGTALVRVVVVDINDNSPEFEQAFYEVKIRENSILGSLILIVSAWDLDSGTNGEICYTFSHASEDIRKTFEINQKSGEITLRAPLDFETIESYSIIIQATDGGGLFGKSTVIIHVIDVNDNAPEITVSSITSPIPENTPETVVMVFSIQDIDSGDNGRIVCSIPEDLPFVLKSSVENYYTLETERPLDRESTAEYNITITVTDLGIPRLKTEHNTTVLVSDVNDNAPTFTQTSYTLFVRENNSPALHIGSVSATDRDSGTNAQVNYSLLPPQDLHLPLASLVSINTDNGHLFALRSLDYEALQAFDFRVGATDRGSPALSSEALVRVLVLDANDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATEPGLFGVWAHNGEVRTARLLSERDAAKHRLVVLVKDNGEPPRSATATLQVLLVDGFSQPYLPLPEAAPAQAQADSLTVYLVVALASVSSLFLFSVLLFVAVRLCRRSRAASVGSCSVPKGPFPGHLVDVSGTGTLSQSYQYEVCLTGGSETNEFKFLKPVIPNIQAKGLGKNSEENSTFRNSFGFNF

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9Y5F2-1; Sequence=Displayed; Name=2; IsoId=Q9Y5F2-2; Sequence=VSP_055931

Alternative Sequence

1..365; Missing (in isoform 2)

Domain & Motif Annotations

Domain (FT)

35..133; Cadherin 1; 138..242; Cadherin 2; 247..347; Cadherin 3; 352..451; Cadherin 4; 456..561; Cadherin 5; 568..671; Cadherin 6

Clinical Relevance1

Antibody

HPA045042

Supporting Publications1

PMID	Title	Abstract
38207106	Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity.	No abstract available