Protein detail

PCDB1

Protocadherin beta-1 (PCDH-beta-1)

Entry name PCDB1	UniProt ID Q9Y5F3	EVMP confidence score 0.38
Supporting publications (n) 1	Transmembrane count 1	Protein classification Predicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information12

Protein Names

Protocadherin beta-1 (PCDH-beta-1)

Protein Class

Predicted membrane proteins

Transmembrane

692..712; Helical

Transmembrane Count

Ensembl

ENSG00000171815

Entrez Gene Symbol

PCDHB1

Gene Synonym

PCDH-BETA1

Gene Description

Protocadherin beta 1

Chromosome

Position

141051374-141059346

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization4

Tissue SpecificliverCell SpecificEarly spermatidsSingle-Nuclei Brain Specificependymal cellBlood Cell Specificbasophil

Function & Pathway5

Cellular Component

GO:0005886 plasma membrane

Molecular Function

GO:0005509 calcium ion binding

Biological Process (3)

KEGG

hsa04519 Cadherin signaling

Mediation Categories

Adhesion and uptake mediation

Relations & Evidence31

Ligand-Receptor Signaling (28)

28 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	CellChatDB	No	Yes	No	Yes	No
receptor	receptor	OmniPath	No	Yes	No	Yes	No
cell_surface_ligand	cell_surface_ligand	CellChatDB	Yes	No	No	Yes	No
cell_surface_ligand	cell_surface_ligand	OmniPath	Yes	No	No	Yes	No
protocadherin	cell_adhesion	HGNC	Yes	Yes	No	Yes	No
adhesion	adhesion	HGNC	Yes	Yes	No	Yes	No
cell_adhesion	cell_adhesion	Zhong2015	Yes	Yes	No	Yes	No
icam	cell_adhesion	Zhong2015	Yes	Yes	No	Yes	No
beta_protocadherin	cell_adhesion	Almen2009	Yes	Yes	No	Yes	No
cell_adhesion	cell_adhesion	Almen2009	Yes	Yes	No	Yes	No

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Protein Complex Composition (2)

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	ATXN7 ATXN7L1 ATXN7L2 ATXN7L3 ENY2 PCDHB15 TSFM USP22 USP27X	A6NNY8 O15265 P43897 Q14CW9 Q5T6C5 Q9NPA8 Q9ULK2 Q9UPT9 Q9Y5E8	0:0:0:0:0:0:0:0:0	hu.MAP2
	ENY2 PCDHB15	Q9NPA8 Q9Y5E8	0:0	hu.MAPhu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometry	2	38225453 40098346

Sequence, Structure & Domains6

Sequences

Length

818

Mass

90,491

Sequence

MAGTRRKSLQNRQVGSLLIFLCISVGDATTIRYSVAEEMESGSFVANVAKDLGLEVGKLAARGARLVSEGNKMHFRLHRKTGDLFVKEKLDRESLCGKADPCVLHFEVVLVEPLQSFRAEVRVFDINDNAPVFLNKEPLLKIPESTPLGSRFPLQSAQDLDVGLNGLQNYTLSANGYFHLHTRFCSHGPKYAELVLNKPLDREEQPEVNLTITAVDGGSPPKSGTAHIHVVVLDVNDHVPQFSRLVYRAQVSENSPNGSLVATVTAVDLDEGTNKAITYSLAQNPEAILKTFQIDPQNGEVRLRGPLDFEAIETYDIDIQATDGGGLSAHSKVLVEVVDVNDNPPEVMVSSVSSPLPEDSPPQTVVALFTIRDRDIRVGGKVTCFLREDLPFVIKPTFGNSYSLVTDRSLDREEVSGYNITIVAMDTGPPSLSAETMIEVLISDVNDNPPIFREDSYILTVRENNSPAVFIGKVHAEDLDLGENAQITYSLLPPKNGDLSVFAYISINSGNGKLYALRTMDYEAIQDFQFVVKATDGGFLSLSSQVTVRVVVLDDNDNRPMILYPLQNGTLPCNDLVPRSAEAGYLVTKVVAVDGDSGQNSWLSYHLLKATDLGLFSVQRQNGEIHTLRQISERDPMMQKLIILVQDHGQPALSTTVSLNILLVDGFSEPYLQFQDPTKHSRKVNPSTKYLVISLVILSFLFLLSVIVIFIIHVYQKIKYREKFTIQEHFYDDCNFSNNLVQGQGNGSLSRPCPYEMCSATGTGNSEFRFLKRFMPNFPFPHATGEIKMEAGSSLPPNSDRNKSQRLEGHDQVSDDYM

Domain & Motif Annotations

Compositional Bias

800..818; Basic and acidic residues

Domain (FT)

35..133; Cadherin 1; 138..242; Cadherin 2; 243..347; Cadherin 3; 348..452; Cadherin 4; 457..562; Cadherin 5; 577..672; Cadherin 6

Region

789..818; Disordered

Clinical Relevance1

Antibody

HPA053921

Supporting Publications1

PMID	Title	Abstract
36114323	Blood plasma derived extracellular vesicles (BEVs): particle purification liquid chromatography (PPLC) and proteomic analysis reveals BEVs as a potential minimally invasive tool for predicting response to breast cancer treatment.	No abstract available