Protein detail

PCDB1

Protocadherin beta-1 (PCDH-beta-1)

Entry name PCDB1	UniProt ID Q9Y5F3	EVMP confidence score 0.40
Supporting publications (n) 1	Transmembrane count 1	Protein classification Predicted membrane proteins

Basic Information

Protein Names

Protocadherin beta-1 (PCDH-beta-1)

Protein Class

Predicted membrane proteins

Transmembrane

692..712; Helical

Transmembrane Count

Ensembl

ENSG00000171815

Entrez Gene Symbol

PCDHB1

Gene Synonym

PCDH-BETA1

Gene Description

Protocadherin beta 1

Chromosome

Position

141051374-141059346

Supporting publications (n)

EVMP confidence score

0.40

Fluorescence & Localization

Tissue SpecificliverCell SpecificEarly spermatidsSingle-Nuclei Brain Specificependymal cellBlood Cell Specificbasophil

Function & Pathway

Cellular Component

GO:0005886 plasma membrane

Molecular Function

GO:0005509 calcium ion binding

Biological Process (3)

KEGG

hsa04519 Cadherin signaling

Mediation Categories

Adhesion and uptake mediation

Relations & Evidence31

Ligand-Receptor Signaling (28)

28 records.

Category	Parent	Database	Plasma Membrane (Transmembrane)
plasma_membrane_transmembrane	plasma_membrane_transmembrane	Membranome	Yes
plasma_membrane_transmembrane	plasma_membrane_transmembrane	OmniPath	Yes
cell_surface	cell_surface	Surfaceome	Yes
cell_surface	cell_surface	OmniPath	Yes
transmembrane	transmembrane_predicted	Phobius	Yes
transmembrane_phobius	transmembrane_predicted	Almen2009	Yes
transmembrane_sosui	transmembrane_predicted	Almen2009	Yes
transmembrane_tmhmm	transmembrane_predicted	Almen2009	Yes

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Protein Complex Composition (2)

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	ATXN7 ATXN7L1 ATXN7L2 ATXN7L3 ENY2 PCDHB15 TSFM USP22 USP27X	A6NNY8 O15265 P43897 Q14CW9 Q5T6C5 Q9NPA8 Q9ULK2 Q9UPT9 Q9Y5E8	0:0:0:0:0:0:0:0:0	hu.MAP2
	ENY2 PCDHB15	Q9NPA8 Q9Y5E8	0:0	hu.MAPhu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometry	2	38225453 40098346

Sequence, Structure & Domains

Sequences

Length

818

Mass

90,491

Sequence

MAGTRRKSLQNRQVGSLLIFLCISVGDATTIRYSVAEEMESGSFVANVAKDLGLEVGKLAARGARLVSEGNKMHFRLHRKTGDLFVKEKLDRESLCGKADPCVLHFEVVLVEPLQSFRAEVRVFDINDNAPVFLNKEPLLKIPESTPLGSRFPLQSAQDLDVGLNGLQNYTLSANGYFHLHTRFCSHGPKYAELVLNKPLDREEQPEVNLTITAVDGGSPPKSGTAHIHVVVLDVNDHVPQFSRLVYRAQVSENSPNGSLVATVTAVDLDEGTNKAITYSLAQNPEAILKTFQIDPQNGEVRLRGPLDFEAIETYDIDIQATDGGGLSAHSKVLVEVVDVNDNPPEVMVSSVSSPLPEDSPPQTVVALFTIRDRDIRVGGKVTCFLREDLPFVIKPTFGNSYSLVTDRSLDREEVSGYNITIVAMDTGPPSLSAETMIEVLISDVNDNPPIFREDSYILTVRENNSPAVFIGKVHAEDLDLGENAQITYSLLPPKNGDLSVFAYISINSGNGKLYALRTMDYEAIQDFQFVVKATDGGFLSLSSQVTVRVVVLDDNDNRPMILYPLQNGTLPCNDLVPRSAEAGYLVTKVVAVDGDSGQNSWLSYHLLKATDLGLFSVQRQNGEIHTLRQISERDPMMQKLIILVQDHGQPALSTTVSLNILLVDGFSEPYLQFQDPTKHSRKVNPSTKYLVISLVILSFLFLLSVIVIFIIHVYQKIKYREKFTIQEHFYDDCNFSNNLVQGQGNGSLSRPCPYEMCSATGTGNSEFRFLKRFMPNFPFPHATGEIKMEAGSSLPPNSDRNKSQRLEGHDQVSDDYM

Domain & Motif Annotations

Compositional Bias

800..818; Basic and acidic residues

Domain (FT)

35..133; Cadherin 1; 138..242; Cadherin 2; 243..347; Cadherin 3; 348..452; Cadherin 4; 457..562; Cadherin 5; 577..672; Cadherin 6

Region

789..818; Disordered

Clinical Relevance

Antibody

HPA053921

Supporting Publications1

PMID	Title	Related sentences
36114323	Blood plasma derived extracellular vesicles (BEVs): particle purification liquid chromatography (PPLC) and proteomic analysis reveals BEVs as a potential minimally invasive tool for predicting response to breast cancer treatment.	No related sentences available