Protein detail

PCDGL

Protocadherin gamma-C4 (PCDH-gamma-C4)

Entry name PCDGL	UniProt ID Q9Y5F7	EVMP score 0.50
Frequency 1	Transmembrane count 1	Protein classification Disease related genesPredicted intracellular proteinsPredicted membrane proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Protocadherin gamma-C4 (PCDH-gamma-C4)

Protein Class

Disease related genesPredicted intracellular proteinsPredicted membrane proteins

Protein Function

Disease related genes
Predicted intracellular proteins

Transmembrane

693..713; Helical

Transmembrane Count

Ensembl

ENSG00000242419

Entrez Gene Symbol

PCDHGC4

Gene Synonym

PCDH-GAMMA-C4

Gene Description

Protocadherin gamma subfamily C, 4

Chromosome

Position

141484997-141512975

Frequency

EVMP Score

0.50

Fluorescence & Localization

Function & Pathway

Protein Function

Disease related genes
Predicted intracellular proteins

Cellular Component

GO:0005886 plasma membrane

Molecular Function

GO:0005509 calcium ion binding

KEGG

hsa04519 Cadherin signaling

Mediation Categories

Adhesion and uptake mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

24 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
cell_adhesion	cell_adhesion	HGNC	Yes	Yes	No	Yes	No
adhesion	adhesion	OmniPath	Yes	Yes	No	Yes	No
cell_adhesion	cell_adhesion	OmniPath	Yes	Yes	No	Yes	No
transmembrane	transmembrane	UniProt_location	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_topology	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	Yes	No
transmembrane	transmembrane	OmniPath	No	No	No	Yes	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	Yes	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	Membranome	No	No	No	Yes	No

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Regulatory Interaction Network

2 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
PCDA2	Q9Y5H9	PCDGL	Q9Y5F7	Yes	Yes	No	SIGNOR	SIGNOR:16697637
PCDAA	Q9Y5I2	PCDGL	Q9Y5F7	Yes	Yes	No	SIGNOR	SIGNOR:16697637

Protein Complex Composition

0 records.

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Western blotting	2	40098346 37922300

Sequence, Structure & Domains

Sequences

Length

938

Mass

101,214

Sequence

MLRKVRSWTEIWRWATLLFLFYHLGYVCGQIRYPVPEESQEGTFVGNVAQDFLLDTDSLSARRLQVAGEVNQRHFRVDLDSGALLIKNPIDREALCGLSASCIVPLEFVTEGPLEMYRAEVEIVDVNDHAPRFPRQQLDLEIGEAAPPGQRFPLEKAQDADVGSNSISSYRLSSNEHFALDVKKRSDGSLVPELLLEKPLDREKQSDYRLVLTAVDGGNPPRSGTAELRVSVLDVNDNAPAFQQSSYRISVLESAPAGMVLIQLNASDPDLGPSGNVTFYFSGHTPDRVRNLFSLHPTTGKLTLLGPLDFESENYYEFDVRARDGGSPAMEQHCSLRVDLLDVNDNAPYITVTSELGTLPESAEPGTVVALISVQDPDSGSNGDVSLRIPDHLPFALKSAFRNQFSLVTAGPLDREAKSSYDIMVTASDAGNPPLSTHRTIFLNISDVNDNPPSFFQRSHEVFVPENNRPGDLLCSLAASDPDSGLNALISYSLLEPRNRDVSASSFISLNPQTGAVHATRSFDYEQTQTLQFEVQARDRGNPPLSSTVTVRLFVLDLNDNAPAVLRPRARPGSLCPQALPPSVGAGHLITKVTAVDLDSGYNAWVSYQLLEAPDPSLFAVSRYAGEVRTAVPIPADLPPQKLVIVVKDSGSPPLSTSVTLLVSLEEDTHPVVPDLRESSAPREGESRLTLYLAVSLVAICFVSFGSFVALLSKCLRGAACGVTCFPAGTCACLTRSRRREGLPPSNGILRIQLGSDDPIKFVDVGGHSHGCTPLASAPTRSDSFMMVKSPSAPMAGEPVRPSCPPSDLLYGLEQAPPNTDWRFSQAQRPGTSGSQNGDDTGTWPNNQFDTEMLQAMILASASEAADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKAPAGGNGNKKKSGKKEKK

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9Y5F7-1; Sequence=Displayed; Name=2; Synonyms=Short; IsoId=Q9Y5F7-2; Sequence=VSP_008700, VSP_008701

Alternative Sequence

815..871; QAPPNTDWRFSQAQRPGTSGSQNGDDTGTWPNNQFDTEMLQAMILASASEAADGSST -> VRPLQAQQMLEGYSDPGIWLGHVLESTGLSVSAHSDVTIFVRGNYVVDAVLCNCFVN (in isoform 2); 872..938; Missing (in isoform 2)

3D Structural Models

Domain & Motif Annotations

Compositional Bias

822..847; Polar residues; 928..938; Basic residues

Domain (FT)

30..133; Cadherin 1; 134..242; Cadherin 2; 243..350; Cadherin 3; 351..455; Cadherin 4; 456..565; Cadherin 5; 572..676; Cadherin 6

Region

791..847; Disordered; 908..938; Disordered

Clinical Relevance

Disease Involvement

Disease variantIntellectual disability

Antibody

HPA008755 HPA010580