Protein detail

PCDGH

Protocadherin gamma-B5 (PCDH-gamma-B5)

Entry name PCDGH	UniProt ID Q9Y5G0	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count 1	Protein classification Predicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information12

Protein Names

Protocadherin gamma-B5 (PCDH-gamma-B5)

Protein Class

Predicted membrane proteins

Transmembrane

688..708; Helical

Transmembrane Count

Ensembl

ENSG00000276547

Entrez Gene Symbol

PCDHGB5

Gene Synonym

PCDH-GAMMA-B5

Gene Description

Protocadherin gamma subfamily B, 5

Chromosome

Position

141397947-141512975

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization1

Cell SpecificLate spermatids

Function & Pathway5

Cellular Component (2)

Molecular Function (2)

Biological Process (3)

KEGG

hsa04519 Cadherin signaling

Mediation Categories

Adhesion and uptake mediation

Relations & Evidence29

Ligand-Receptor Signaling (26)

26 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	CellChatDB	No	Yes	No	Yes	No
receptor	receptor	OmniPath	No	Yes	No	Yes	No
extracellular	extracellular	OmniPath	No	No	No	Yes	No
intracellular	intracellular	ComPPI	No	No	No	Yes	No
intracellular	intracellular	OmniPath	No	No	No	Yes	No
cell_surface_ligand	cell_surface_ligand	CellChatDB	Yes	No	No	Yes	No
cell_surface_ligand	cell_surface_ligand	OmniPath	Yes	No	No	Yes	No
protocadherin	cell_adhesion	HGNC	Yes	Yes	No	Yes	No
adhesion	adhesion	HGNC	Yes	Yes	No	Yes	No
cell_adhesion	cell_adhesion	Zhong2015	Yes	Yes	No	Yes	No

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Regulatory Interaction Network (2)

2 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
PCDAA	Q9Y5I2	PCDGH	Q9Y5G0	Yes	Yes	No	SIGNOR	SIGNOR:16697637
PCDA2	Q9Y5H9	PCDGH	Q9Y5G0	Yes	Yes	No	SIGNOR	SIGNOR:16697637

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometry	13	36064647 38113368 40465195 37322475 40189497 41068253 33592500 41307968 40840701 38207106 34576246 37204515 39207047

Sequence, Structure & Domains8

Sequences

Length

923

Mass

99,875

Sequence

MGSGAGELGRAERLPVLFLFLLSLFCPALCEQIRYRIPEEMPKGSVVGNLATDLGFSVQELPTRKLRVSSEKPYFTVSAESGELLVSSRLDREEICGKKPACALEFEAVAENPLNFYHVNVEIEDINDHTPKFTQNSFELQISESAQPGTRFILEVAEDADIGLNSLQKYKLSLNPSFSLIIKEKQDGSKYPELALEKTLDREQQSYHRLVLTALDGGHPPLSGTTELRIQVTDANDNPPVFNRDVYRVSLRENVPPGTTVLQVSATDQDEGINSEITYSFYRTGQIFSLNSKSGEITTQKKLDFEETKEYSMVVEGRDGGGLVAQCTVEINIQDENDNSPEVTFHSLLEMILENAVPGTLIALIKIHDQDSGENGEVNCQLQGEVPFKIISSSKNSYKLVTDGTLDREQTPEYNVTITATDRGKPPLSSSISVILHIRDVNDNAPVFHQASYLVSVPENNPPGASIAQVCASDLDLGLNGQVSYSIMASDLEPLALASYVSMSAQSGVVFAQRAFDYEQLRTFELTLQARDQGSPALSANVSLRVLVGDRNDNAPRVLYPALGPDGSALFDMVPRAAEPGYLVTKVVAVDADSGHNAWLSYHVLQASEPGLFSLGLRTGEVRTARALGDRDAARQRLLVAVRDGGQPPLSATATLHLVFADSLQEVLPDITDRPVPSDPQAELQFYLVVALALISVLFLLAVILAVALRLRRSSSPAAWSCFQPGLCVKSGPVVPPNYSQGTLPYSYNLCVAHTGKTEFNFLKCSEQLSSGQDILCGDSSGALFPLCNSSESTSHPELQAPPNTDWRFSQAQRPGTSGSQNGDDTGTWPNNQFDTEMLQAMILASASEAADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKAPAGGNGNKKKSGKKEKK

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9Y5G0-1; Sequence=Displayed; Name=2; Synonyms=Short; IsoId=Q9Y5G0-2; Sequence=VSP_008692, VSP_008693

Alternative Sequence

800..818; QAPPNTDWRFSQAQRPGTS -> VSFIYVYSFSLPTQFSVFT (in isoform 2); 819..923; Missing (in isoform 2)

Domain & Motif Annotations

Compositional Bias

807..832; Polar residues; 913..923; Basic residues

Domain (FT)

31..133; Cadherin 1; 134..242; Cadherin 2; 243..343; Cadherin 3; 344..448; Cadherin 4; 449..558; Cadherin 5; 566..671; Cadherin 6

Region

794..832; Disordered; 893..923; Disordered

Clinical Relevance1

Antibody (2)

HPA008755 HPA010580

Supporting Publications1

PMID	Title	Abstract
32308722	Antiangiogenesis Roles of Exosomes with Fei-Liu-Ping Ointment Treatment are Involved in the Lung Carcinoma with the Lewis Xenograft Mouse Model.	In the present study, the values of VEGF and PDGF, which were closely related to angiogenesis, were estimated in serum and carcinoma tissue exosomes to unveil the FLP effects on angiogenesis.