Protein detail

PCDGE

Protocadherin gamma-B2 (PCDH-gamma-B2)

Entry name PCDGE	UniProt ID Q9Y5G2	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count 1	Protein classification Predicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information12

Protein Names

Protocadherin gamma-B2 (PCDH-gamma-B2)

Protein Class

Predicted membrane proteins

Transmembrane

692..712; Helical

Transmembrane Count

Ensembl

ENSG00000253910

Entrez Gene Symbol

PCDHGB2

Gene Synonym

PCDH-GAMMA-B2

Gene Description

Protocadherin gamma subfamily B, 2

Chromosome

Position

141359994-141512975

Supporting publications (n)

EVMP confidence score

0.50

Function & Pathway5

Cellular Component

GO:0005886 plasma membrane

Molecular Function

GO:0005509 calcium ion binding

Biological Process (3)

KEGG

hsa04519 Cadherin signaling

Mediation Categories

Adhesion and uptake mediation

Relations & Evidence29

Ligand-Receptor Signaling (25)

25 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
plasma_membrane_transmembrane	plasma_membrane_transmembrane	Membranome	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	OmniPath	No	No	No	Yes	No
cell_surface	cell_surface	Surfaceome	No	No	No	Yes	No
cell_surface	cell_surface	OmniPath	No	No	No	Yes	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	Yes	No

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Regulatory Interaction Network (2)

2 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
PCDAA	Q9Y5I2	PCDGE	Q9Y5G2	Yes	Yes	No	SIGNOR	SIGNOR:16697637
PCDA2	Q9Y5H9	PCDGE	Q9Y5G2	Yes	Yes	No	SIGNOR	SIGNOR:16697637

Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
Pcdha7-Pcdhgb2 complex	PCDHA7 PCDHGB2	Q9UN72 Q9Y5G2	1:1	Compleat	Compleat:HC1626	15347688

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Western blotting	1	40189497

Sequence, Structure & Domains8

Sequences

Length

931

Mass

100,875

Sequence

MKASSGRCGLVRWLQVLLPFLLSLFPGALPVQIRYSIPEELAKNSVVGNLAKDLGLSVRDLPARKLRVSAEKEYFTVNPESGDLLVSDRIDREQICGKQPLCVLDFDTVAENPLNIFYIAVIVQDINDNTPLFKQTKINLKIGESTKPGTTFPLDPALDSDVGPNSLQRYHLNDNEYFDLAEKQTPDGRKYPELILKHSLDREEHSLHQLVLTAVDGGDPPQSGTTQIRIKVTDANDNPPVFSQDVYRVTLREDVPPGFFVLQVTATDRDEGINAEITYSFHNVDEQVKHFFNLNEKTGEITTKDDLDFEIASSYTLSIEAKDPGDLAAHCSIQVEILDDNDCAPEVIVTSVSTPLPEDSPPGTVIALIKTRDRDSGENGEVYCQVLGNAKFILKSSSKNYYKLVTDGALDREEIPEYNLTITATDGGKPPLSSSIIVTLHISDVNDNAPVFQQTSYMVHVAENNPPGASIAQISASDPDLGPSGQVSYSIVASDLKPREILSYVSVSAQSGVVFAQRAFDHEQLRAFELTLQARDQGSPALSANVSLRVLVGDLNDNAPRVLYPALGPDGSALFDMVPRAAEPGYLVTKVVAVDADSGHNAWLSYHVLQASEPGLFSLGLRTGEVRTARALGDRDAARQRLLVAVRDGGQPPLSATATLHLIFADSLQEVLPDLSDRREPSDPQAKLQFYLVVALALISVLFFLAVILAISLRLRLSSRSDAWDCFQPGLSSKPGPGVLPNYSEGTLPYSYNLCVASQSAKTEFNFLNITPELVPAQDLVCDNASWEQNTNHGAAGVPFASDTILKQAPPNTDWRFSQAQRPGTSGSQNGDDTGTWPNNQFDTEMLQAMILASASEAADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKAPAGGNGNKKKSGKKEKK

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9Y5G2-1; Sequence=Displayed; Name=2; Synonyms=Short; IsoId=Q9Y5G2-2; Sequence=VSP_008686, VSP_008687

Alternative Sequence

808..811; QAPP -> VSFN (in isoform 2); 812..931; Missing (in isoform 2)

Domain & Motif Annotations

Compositional Bias

815..840; Polar residues; 921..931; Basic residues

Domain (FT)

31..133; Cadherin 1; 134..242; Cadherin 2; 243..347; Cadherin 3; 348..452; Cadherin 4; 453..562; Cadherin 5; 570..675; Cadherin 6

Region

814..840; Disordered; 901..931; Disordered

Clinical Relevance1

Antibody (3)

HPA008755 HPA010580 HPA077526

Supporting Publications1

PMID	Title	Abstract
40689422	Defining the Ovarian Cancer Precancerous Landscape through Modeling Fallopian Tube Epithelium Reprogramming Driven by Extracellular Vesicles.	No abstract available