Protein detail

PCDG7

Protocadherin gamma-A7 (PCDH-gamma-A7)

Entry name PCDG7	UniProt ID Q9Y5G6	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count 1	Protein classification Predicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information12

Protein Names

Protocadherin gamma-A7 (PCDH-gamma-A7)

Protein Class

Predicted membrane proteins

Transmembrane

693..713; Helical

Transmembrane Count

Ensembl

ENSG00000253537

Entrez Gene Symbol

PCDHGA7

Gene Synonym

PCDH-GAMMA-A7

Gene Description

Protocadherin gamma subfamily A, 7

Chromosome

Position

141382739-141512975

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization3

Tissue Specificheart muscleCell SpecificCardiomyocytesSingle-Nuclei Brain Specificvascular associated smooth muscle cell

Function & Pathway6

Cellular Component

GO:0005886 plasma membrane

Molecular Function

GO:0005509 calcium ion binding

Biological Process (3)

KEGG

hsa04519 Cadherin signaling

Canonical Pathways

M142 Pid ajdiss 2pathway

Mediation Categories

Adhesion and uptake mediation

Relations & Evidence29

Ligand-Receptor Signaling (26)

26 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	CellChatDB	No	Yes	No	Yes	No
receptor	receptor	OmniPath	No	Yes	No	Yes	No
intracellular	intracellular	ComPPI	No	No	No	Yes	No
intracellular	intracellular	OmniPath	No	No	No	Yes	No
cell_surface_ligand	cell_surface_ligand	CellChatDB	Yes	No	No	Yes	No
cell_surface_ligand	cell_surface_ligand	OmniPath	Yes	No	No	Yes	No
protocadherin	cell_adhesion	HGNC	Yes	Yes	No	Yes	No
adhesion	adhesion	HGNC	Yes	Yes	No	Yes	No
cell_adhesion	cell_adhesion	Cellinker	Yes	Yes	No	Yes	No
cell_adhesion	cell_adhesion	Zhong2015	Yes	Yes	No	Yes	No

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Regulatory Interaction Network (2)

2 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
PCDAA	Q9Y5I2	PCDG7	Q9Y5G6	Yes	Yes	No	SIGNOR	SIGNOR:16697637
PCDA2	Q9Y5H9	PCDG7	Q9Y5G6	Yes	Yes	No	SIGNOR	SIGNOR:16697637

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometry	7	36064647 38113368 40465195 37322475 41068253 36146834 32230970

Sequence, Structure & Domains8

Sequences

Length

932

Mass

101,722

Sequence

MAAQPRGGDYRGFFLLSILLGTPWEAWAGRILYSVSEETDKGSFVGDIAKDLGLEPRELAERGVRIISRGRTQLFALNQRSGSLVTAGRIDREEICAQSARCLVNFNILMEDKMNLYPIDVEIIDINDNVPRFLTEEINVKIMENTAPGVRFPLSEAGDPDVGTNSLQSYQLSPNRHFSLAVQSGDDETKYPELVLERVLDREEERVHHLVLTASDGGDPPRSSTAHIQVTVVDVNDHTPVFSLPQYQVTVPENVPVGTRLLTVHAIDLDEGVNGEVTYSFRKITPKLPKMFHLNSLTGEISTLEGLDYEETAFYEMEVQAQDGPGSLTKAKVLITVLDVNDNAPEVTMTSLSSSIPEDTPLGTVIALFYLQDRDSGKNGEVTCTIPENLPFKLEKSIDNYYRLVTTKNLDRETLSLYNITLKATDGGTPPLSRETHIFMQVADTNDNPPTFPHSSYSVYIAENNPRGASIFLVTAQDHDSEDNAQITYSLAEDTIQGAPVSSYVSINSDTGVLYALQSFDYEQLRELQLRVTAHDSGDPPLSSNMSLSLFVLDQNDNPPEILYPALPTDGSTGMELAPRSAEPGYLVTKVVAVDKDSGQNAWLSYLLLKASEPGLFAVGLYTGEVRTARALLDRDALKQSLVVAVQDHGQPPLSATVTLTVAVADSIPEVLADLGSLEPSDGPYNYDLTLYLVVAVATVSCVFLAFVLVLLALRLRRWHKSRLLQASEGGLANVPTSHFVGMDGVQAFLQTYSHEVSLTADSRKSHLIFPQPNYVDMLISQESCEKNDSLLTSVDFQECKENLPSIQQAPPNTDWRFSQAQRPGTSGSQNGDDTGTWPNNQFDTEMLQAMILASASEAADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKAPAGGNGNKKKSGKKEKK

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9Y5G6-1; Sequence=Displayed; Name=2; Synonyms=Short; IsoId=Q9Y5G6-2; Sequence=VSP_008671, VSP_008672

Alternative Sequence

809..817; QAPPNTDWR -> VSPALPLFP (in isoform 2); 818..932; Missing (in isoform 2)

Domain & Motif Annotations

Compositional Bias

922..932; Basic residues

Domain (FT)

29..133; Cadherin 1; 134..242; Cadherin 2; 243..347; Cadherin 3; 348..452; Cadherin 4; 453..562; Cadherin 5; 570..682; Cadherin 6

Region

805..841; Disordered; 902..932; Disordered

Clinical Relevance1

Antibody (2)

HPA008755 HPA010580

Supporting Publications1

PMID	Title	Abstract
39940641	Disease-Associated Signatures Persist in Extracellular Vesicles from Reprogrammed Cells of Osteoarthritis Patients.	No abstract available