Protein detail

PCDG6

Protocadherin gamma-A6 (PCDH-gamma-A6)

Protein symbol PCDG6	UniProt ID Q9Y5G7	EVMP score 0.50
Frequency 5	Transmembrane count 1	Protein classification Predicted membrane proteins

Basic Information

Protein Names

Protocadherin gamma-A6 (PCDH-gamma-A6)

Protein Class

Predicted membrane proteins

Transmembrane

693..713; Helical

Transmembrane Count

Ensembl

ENSG00000253731

Entrez Gene Symbol

PCDHGA6

Gene Synonym

PCDH-GAMMA-A6

Gene Description

Protocadherin gamma subfamily A, 6

Chromosome

Position

141373891-141512975

Frequency

EVMP Score

0.50

Fluorescence & Localization

Function & Pathway

Cellular Component

GO:0005886 plasma membrane

Molecular Function

GO:0005509 calcium ion binding

Biological Process

KEGG

hsa04519 Cadherin signaling

Mediation Categories

Adhesion and uptake mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

22 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
cell_surface	cell_surface	OmniPath	No	No	No	Yes	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	Yes	No

Page 3 of 3Previous

Regulatory Interaction Network

2 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
PCDA2	Q9Y5H9	PCDG6	Q9Y5G7	Yes	Yes	No	SIGNOR	SIGNOR:16697637
PCDAA	Q9Y5I2	PCDG6	Q9Y5G7	Yes	Yes	No	SIGNOR	SIGNOR:16697637

Protein Complex Composition

0 records.

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometry	3	36064647 38113368 41068253

Sequence, Structure & Domains

Sequences

Length

932

Mass

100,871

Sequence

MAPPQRHPQRSEQVLLLTLLGTLWGAAAAQIRYSIPEELEKGSFVGNIVKDLGLEPQELAEHGVRIVSRGRMQLFSLNPRNGSLVTAGRIDREELCAQSPRCLVSFNILVEDKLNLYPVEVEIVDINDNTPRFLKEELEVKILENAAPSSRFPLMEVYDPDVGMNSLQGFKLSGNSHFSVDVQSEAHGPKYPELVLEGTLDREGEAVYRLVLTAMDGGDPVRSSVAQILVTVLDVNDNTPMFTQPVYRVSVPENLPVGTPVLAVTATDQDEGVHGEVTYSFVKITEKISQIFCLNVLTGEISTSANLDYEDSSFYELGVEARDGPGLRDRAKVLITILDVNDNVPEVVVTSGSRTIAESAPPGTVIALFQVFDRDSGLNGLVTCSIPRSLPFELEKSVGNYYRLVTNAALDREEVFLYNITVTATDKGTPPLSTETIISLNVADTNDNPPTFPHSSYSVYVLENNPRGASIFSVNALDPDVDQNAQVSYSLAEDTLQGAPLSSYVSINSDTGILYALRSFDYEQLRDLQLWVTASDSGDPPLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDRDSGQNAWLSYRLLKASEPGLFSVGLHTGEVRTARALLDRDALKQSLVVAVQDHGQPPLSATVTLTVAVADRIPDILADLGSLEPSAKPNDSDLTLYLVVAVAAVSCVFLAFVIVLLALRLQRWHKSRLLQASGGGLASMPGSHFVGVEGVRAFLQTYSHEVSLTADSRKSHLIFPQPNYADTLINQESYEKSEPLLITQDLLETKGEPRQLQQAPPNTDWRFSQAQRPGTSGSQNGDDTGTWPNNQFDTEMLQAMILASASEAADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKAPAGGNGNKKKSGKKEKK

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9Y5G7-1; Sequence=Displayed; Name=2; Synonyms=Short; IsoId=Q9Y5G7-2; Sequence=VSP_008669, VSP_008670

Alternative Sequence

809..818; QAPPNTDWRF -> VSFFPPKREE (in isoform 2); 819..932; Missing (in isoform 2)

3D Structural Models

Domain & Motif Annotations

Compositional Bias

806..841; Polar residues; 922..932; Basic residues

Domain (FT)

30..133; Cadherin 1; 134..242; Cadherin 2; 243..347; Cadherin 3; 348..452; Cadherin 4; 453..562; Cadherin 5; 570..682; Cadherin 6

Region

804..841; Disordered; 902..932; Disordered

Clinical Relevance

Antibody

HPA008755 HPA010580