Protein detail

PCDG3

Protocadherin gamma-A3 (PCDH-gamma-A3)

Entry name PCDG3	UniProt ID Q9Y5H0	EVMP confidence score 0.50
Supporting publications (n) 3	Transmembrane count 1	Protein classification Predicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information12

Protein Names

Protocadherin gamma-A3 (PCDH-gamma-A3)

Protein Class

Predicted membrane proteins

Transmembrane

693..713; Helical

Transmembrane Count

Ensembl

ENSG00000254245

Entrez Gene Symbol

PCDHGA3

Gene Synonym

PCDH-GAMMA-A3

Gene Description

Protocadherin gamma subfamily A, 3

Chromosome

Position

141343829-141512975

Supporting publications (n)

EVMP confidence score

0.50

Function & Pathway5

Cellular Component

GO:0005886 plasma membrane

Molecular Function (2)

Biological Process (3)

KEGG

hsa04519 Cadherin signaling

Mediation Categories

Adhesion and uptake mediation

Relations & Evidence30

Ligand-Receptor Signaling (26)

26 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
cell_adhesion	cell_adhesion	Zhong2015	Yes	Yes	No	Yes	No
icam	cell_adhesion	Zhong2015	Yes	Yes	No	Yes	No
cell_adhesion	cell_adhesion	HGNC	Yes	Yes	No	Yes	No
adhesion	adhesion	OmniPath	Yes	Yes	No	Yes	No
cell_adhesion	cell_adhesion	OmniPath	Yes	Yes	No	Yes	No
transmembrane	transmembrane	UniProt_location	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_topology	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	Yes	No
transmembrane	transmembrane	OmniPath	No	No	No	Yes	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	Yes	No

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Regulatory Interaction Network (2)

2 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
PCDAA	Q9Y5I2	PCDG3	Q9Y5H0	Yes	Yes	No	SIGNOR	SIGNOR:16697637
PCDA2	Q9Y5H9	PCDG3	Q9Y5H0	Yes	Yes	No	SIGNOR	SIGNOR:16697637

Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
Pcdha7-Pcdhga3 complex	PCDHA7 PCDHGA3	Q9UN72 Q9Y5H0	1:1	Compleat	Compleat:HC3407	15347688

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	5	37322475 33592500 32854315 32560723 39207047

Sequence, Structure & Domains8

Sequences

Length

932

Mass

100,971

Sequence

MTNCLSFRNGRGLALLCALLGTLCETGSGQIRYSVSEELDKGSFVGNIANDLGLEPRELAERGVRIVSRGRTQLFSLNPQSGSLVTAERIDREELCAQIPLCLVKINILVEDKLKIFEVEIEIKDINDNAPNFPTEELEIKIGELTVPGTRFPIKTAFDPDVGINSLQNYKLSPNDYFSLAVNSVSEGAKYPELVLERALDREKKEIHQLVLVASDGGDPVHSGNLHIQVIVLDANDNPPMFTQPEYRVSVWENVPVGTRLLTVNATDPDEGFNAQVSYILDKMPGKIAEIFHLNSVSGEVSILKSLDYEDAMFYEIKIEAQDGPGLLSRAKILVTVLDVNDNAPEITITSLTSSVPEEGTVGREIALIDVHDRDSGQNGQVEVFVLGNLPFKLEKSIDQYYRLVTATSLDREQISEYNISLRASDGGSPPLSTETHITLHVIDINDNPPTFPHLSYSAYIPENNPRGASIFSVTAQDPDSNNNARITYALTEDTLQGAPLSSFVSINSNTGVLYALRSFDYEQFRDLKLLVTASDSGNPPLSSNVSLNLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDRDSGQNAWLSYRLLKASEPGLFSVGLHTGEVRTARALLDRDALKQSLVVAVQDHGQPPLSATVTLTVAVADRIPDILADLGSLEPSAKPNDSDLTLYLVVAVAAVSCVFLAFVIVLLALRLRRWHKSRLLQASGGGLASTPGSHFVGADGVRAFLQTYSHEVSLTADSRKSHLIFPQPNYADTLISQESCEKSEPLLITQDLLEMKGDSNLLQQAPPNTDWRFSQAQRPGTSGSQNGDDTGTWPNNQFDTEMLQAMILASASEAADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKAPAGGNGNKKKSGKKEKK

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9Y5H0-1; Sequence=Displayed; Name=2; Synonyms=Short; IsoId=Q9Y5H0-2; Sequence=VSP_008663, VSP_008664

Alternative Sequence

809..829; QAPPNTDWRFSQAQRPGTSGS -> VSLFISLIIKNKYENVVIIKL (in isoform 2); 830..932; Missing (in isoform 2)

Domain & Motif Annotations

Compositional Bias

922..932; Basic residues

Domain (FT)

30..133; Cadherin 1; 134..242; Cadherin 2; 243..347; Cadherin 3; 348..452; Cadherin 4; 453..562; Cadherin 5; 570..682; Cadherin 6

Region

805..841; Disordered; 902..932; Disordered

Clinical Relevance1

Antibody (2)

HPA008755 HPA010580

Supporting Publications3

PMID	Title	Abstract
30071318	Changes in the urinary extracellular vesicle proteome are associated with nephronophthisis-related ciliopathies.	No abstract available
33580265	Proteomic Profile of Urinary Extracellular Vesicles Identifies AGP1 as a Potential Biomarker of Primary Aldosteronism.	No abstract available
38225453	Deep proteomic analysis of obstetric antiphospholipid syndrome by DIA-MS of extracellular vesicle enriched fractions.	No abstract available