Protein detail
PCDG2
Protocadherin gamma-A2 (PCDH-gamma-A2)
Entry name PCDG2 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 1 | Protein classification Plasma proteinsPredicted membrane proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Protocadherin gamma-A2 (PCDH-gamma-A2)
Protein Class
Plasma proteinsPredicted membrane proteins
Transmembrane
693..713; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
PCDH-GAMMA-A2
Gene Description
Protocadherin gamma subfamily A, 2
Chromosome
5
Position
141338760-141512975
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue SpecificcervixCell SpecificEsophageal apical cellsSingle-Nuclei Brain Specificependymal cell
Function & Pathway
Cellular Component
Molecular Function
Biological Process
Mediation Categories
Adhesion and uptake mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
22 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | CellChatDB | No | Yes | No | Yes | No |
| receptor | receptor | OmniPath | No | Yes | No | Yes | No |
| cell_surface_ligand | cell_surface_ligand | CellChatDB | Yes | No | No | Yes | No |
| cell_surface_ligand | cell_surface_ligand | OmniPath | Yes | No | No | Yes | No |
| protocadherin | cell_adhesion | HGNC | Yes | Yes | No | Yes | No |
| adhesion | adhesion | HGNC | Yes | Yes | No | Yes | No |
| cell_adhesion | cell_adhesion | Zhong2015 | Yes | Yes | No | Yes | No |
| icam | cell_adhesion | Zhong2015 | Yes | Yes | No | Yes | No |
| cell_adhesion | cell_adhesion | HGNC | Yes | Yes | No | Yes | No |
| adhesion | adhesion | OmniPath | Yes | Yes | No | Yes | No |
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Regulatory Interaction Network
2 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| PCDAA | Q9Y5I2 | PCDG2 | Q9Y5H1 | Yes | Yes | No | SIGNOR | SIGNOR:16697637 |
| PCDA2 | Q9Y5H9 | PCDG2 | Q9Y5H1 | Yes | Yes | No | SIGNOR | SIGNOR:16697637 |
Protein Complex Composition
0 records.
Sequence, Structure & Domains
Sequences
Length
932
Mass
101,484
Sequence
MAALQKLPHCRKLVLLCFLLATLWEARAGQIRYSVREEIDRGSFVGNIAKDLGLEPLALAEQGVRIVSRGRSQLFALNPRSGSLVTANRIDREELCAQSAPCLLNFNILLEDKLTIYSVEVEITDINDNAPRFGVEELELKISETTTPGFRIPLKNAHDADVGENALQKYALNPNDHFSLDVRRGADGNKYPELVLERSLDREEEAVHHLVLVASDGGDPVLSGTSRICVKVLDANDNAPVFTQPEYRISIPENTLVGTRILTVTATDADEGYYAQVVYFLEKSPGETSEVFELKSTSGELTIIKDLDYEDATFHEIDIEAQDGPGLLTRAKVIVTVLDVNDNAPEFYMTSATSSVSEDSLPGTIIGLFNVHDRDSGQNAFTTCSLPEDLPFKLEKSVDNYYRLVTTRALDREQFSFYNITLTAKDGGNPSLSTDAHILLQVADINDNAPAFSRTSYSTYIPENNPRGASVFSVTAHDPDSNDNAHVTYSFAEDTVQGAPLSSYISINSDTGVLYALRSFDYEQLRDLQVWVIARDSGNPPLSSNVSLSLFVLDQNDNAPEILYPAFPTDGSTGVELAPRSAEPGYLVTKVVAVDRDSGQNAWLSYHLLKASEPGLFSVGLHTGEVRTARALLDRDALKQSLVVAIQDHGQPPLSATVTLTVAVADRIPDILADLGSLEPSAIPNDSDLTLYLVVAVAAVSCVFLAFVIVLLAHRLRRWHKSRLLQASGGSLTGMQSSHFVGVDGVRAFLQTYSHEVSLTADSRKSHLIFPQPNYADTLISQESCEKKDFLSAPQSLLEEEREETFSQQAPPNTDWRFSQAQRPGTSGSQNGDDTGTWPNNQFDTEMLQAMILASASEAADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKAPAGGNGNKKKSGKKEKK
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9Y5H1-1; Sequence=Displayed; Name=2; Synonyms=Short; IsoId=Q9Y5H1-2; Sequence=VSP_008661, VSP_008662
Alternative Sequence
809..823; QAPPNTDWRFSQAQR -> VIYLFTTYVLASLLK (in isoform 2); 824..932; Missing (in isoform 2)
3D Structural Models
Domain & Motif Annotations
Compositional Bias
806..841; Polar residues; 922..932; Basic residues
Domain (FT)
29..133; Cadherin 1; 134..242; Cadherin 2; 243..347; Cadherin 3; 348..452; Cadherin 4; 453..562; Cadherin 5; 570..682; Cadherin 6
Region
798..841; Disordered; 902..932; Disordered