Protein detail

PCDGB

Protocadherin gamma-A11 (PCDH-gamma-A11)

Entry name PCDGB	UniProt ID Q9Y5H2	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count 1	Protein classification Plasma proteinsPredicted intracellular proteinsPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Protocadherin gamma-A11 (PCDH-gamma-A11)

Protein Class (3)

Plasma proteinsPredicted intracellular proteinsPredicted membrane proteins

Protein Function

Predicted intracellular proteins

Transmembrane

694..714; Helical

Transmembrane Count

Ensembl

ENSG00000253873

Entrez Gene Symbol

PCDHGA11

Gene Synonym

PCDH-GAMMA-A11

Gene Description

Protocadherin gamma subfamily A, 11

Chromosome

Position

141421047-141512975

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization3

Tissue Specificlymphoid tissueCell SpecificB-cellsSingle-Nuclei Brain Specificleukocyte

Function & Pathway7

Protein Function

Predicted intracellular proteins

Cellular Component

GO:0005886 plasma membrane

Molecular Function

GO:0005509 calcium ion binding

Biological Process (3)

KEGG

hsa04519 Cadherin signaling

Canonical Pathways

M214 Pid erbb1 internalization pathway

Mediation Categories

Adhesion and uptake mediation

Relations & Evidence29

Ligand-Receptor Signaling (25)

25 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	CellChatDB	No	Yes	No	Yes	No
receptor	receptor	OmniPath	No	Yes	No	Yes	No
intracellular	intracellular	ComPPI	No	No	No	Yes	No
intracellular	intracellular	OmniPath	No	No	No	Yes	No
cell_surface_ligand	cell_surface_ligand	CellChatDB	Yes	No	No	Yes	No
cell_surface_ligand	cell_surface_ligand	OmniPath	Yes	No	No	Yes	No
protocadherin	cell_adhesion	HGNC	Yes	Yes	No	Yes	No
adhesion	adhesion	HGNC	Yes	Yes	No	Yes	No
cell_adhesion	cell_adhesion	Zhong2015	Yes	Yes	No	Yes	No
icam	cell_adhesion	Zhong2015	Yes	Yes	No	Yes	No

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Regulatory Interaction Network (2)

2 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
PCDA2	Q9Y5H9	PCDGB	Q9Y5H2	Yes	Yes	No	SIGNOR	SIGNOR:16697637
PCDAA	Q9Y5I2	PCDGB	Q9Y5H2	Yes	Yes	No	SIGNOR	SIGNOR:16697637

Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	DKKL1 PCDHGA11 PEX6	Q13608 Q9UK85 Q9Y5H2	0:0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Mass spectrometry	14	40189497 26826536 40465195 37322475 33304478 36497184 34064677 32854315 30915084 41307968 36146834 31805958 38207106 39207047

Sequence, Structure & Domains8

Sequences

Length

935

Mass

101,543

Sequence

MANRLQRGDRSRLLLLLCIFLGTLRGFRARQIRYSVPEETEKGSFVGNISKDLGLEPRELAKRGVRIVSRGKTQLFAVNPRSGSLITAGRIDREELCETVSSCFLNMELLVEDTLKIYGVEVEIIDINDNAPSFQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQLSPNNYFSLQLRGRTDGAKNPELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHIPMFTQSVYRVSVPENISSGTRVLMVNATDPDEGINGEVMYSFRNMESKASEIFQLDSQTGEVQVRGSLDFEKYRFYEMEIQGQDGGGLFTTTTMLITVVDVNDNAPEITITSSINSILENSPPGTVIALLNVQDQDSGENGQVSCFIPNHLPFKLEKTYGNYYKLITSRVLDRELVQSYNITLTATDQGSPPLSAETHVWLNVADDNDNPPVFPHSSYSAYIPENNPRGASIFSVTALDPDSKQNALVTYSLTDDTVQGVPLSSYVSINSNTGVLYALQSFDYEQFRDLELRVIARDSGDPPLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSGQNAWLSYRLLKASEPGLFAVGEHTGEVRTARALLDRDALKQSLVVAVQDHGQPPLSATVTLTVAVADSIPEVLADLGSLESLANSETSDLSLYLVVAVAAVSCIFLVFVIVLLALRLWRWHKSRLLQASEGGLAGMPTSHFVGVDGVQAFLQTYSHEVSLIADSQKSHLIFPQPNYGDTLISQESCEKSEPLLIAEDSAIILGKCDPTSNQQAPPNTDWRFSQAQRPGTSGSQNGDDTGTWPNNQFDTEMLQAMILASASEAADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKAPAGGNGNKKKSGKKEKK

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9Y5H2-1; Sequence=Displayed; Name=2; Synonyms=Short; IsoId=Q9Y5H2-2; Sequence=VSP_008680, VSP_008681; Name=3; IsoId=Q9Y5H2-3; Sequence=VSP_008679

Alternative Sequence

627..811; Missing (in isoform 3); 812..837; QAPPNTDWRFSQAQRPGTSGSQNGDD -> VRFISLPPNCWCLGTSLLRRCFLSLL (in isoform 2); 838..935; Missing (in isoform 2)

Domain & Motif Annotations

Compositional Bias

807..844; Polar residues; 925..935; Basic residues

Domain (FT)

30..134; Cadherin 1; 135..243; Cadherin 2; 244..348; Cadherin 3; 349..453; Cadherin 4; 454..563; Cadherin 5; 571..677; Cadherin 6

Region

805..844; Disordered; 905..935; Disordered

Clinical Relevance1

Antibody (2)

HPA008755 HPA010580

Supporting Publications1

PMID	Title	Abstract
27487081	Comparative Proteomic Analysis of Extracellular Vesicles Isolated by Acoustic Trapping or Differential Centrifugation.	No abstract available