Protein detail

PCDGA

Protocadherin gamma-A10 (PCDH-gamma-A10)

Entry name PCDGA	UniProt ID Q9Y5H3	EVMP confidence score 0.63
Supporting publications (n) 6	Transmembrane count 1	Protein classification Predicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information12

Protein Names

Protocadherin gamma-A10 (PCDH-gamma-A10)

Protein Class

Predicted membrane proteins

Transmembrane

697..717; Helical

Transmembrane Count

Ensembl

ENSG00000253846

Entrez Gene Symbol

PCDHGA10

Gene Synonym

PCDH-GAMMA-A10

Gene Description

Protocadherin gamma subfamily A, 10

Chromosome

Position

141412987-141512975

Supporting publications (n)

EVMP confidence score

0.63

Fluorescence & Localization3

Tissue SpecificbrainCell SpecificBrain excitatory neuronsSingle-Nuclei Brain Specificcerebellar inhibitory

Function & Pathway5

Cellular Component

GO:0005886 plasma membrane

Molecular Function

GO:0005509 calcium ion binding

Biological Process (3)

KEGG

hsa04519 Cadherin signaling

Mediation Categories

Adhesion and uptake mediation

Relations & Evidence25

Ligand-Receptor Signaling (22)

22 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	CellChatDB	No	Yes	No	Yes	No
receptor	receptor	OmniPath	No	Yes	No	Yes	No
cell_surface_ligand	cell_surface_ligand	CellChatDB	Yes	No	No	Yes	No
cell_surface_ligand	cell_surface_ligand	OmniPath	Yes	No	No	Yes	No
protocadherin	cell_adhesion	HGNC	Yes	Yes	No	Yes	No
adhesion	adhesion	HGNC	Yes	Yes	No	Yes	No
cell_adhesion	cell_adhesion	Zhong2015	Yes	Yes	No	Yes	No
icam	cell_adhesion	Zhong2015	Yes	Yes	No	Yes	No
cell_adhesion	cell_adhesion	HGNC	Yes	Yes	No	Yes	No
adhesion	adhesion	OmniPath	Yes	Yes	No	Yes	No

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Regulatory Interaction Network (2)

2 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
PCDAA	Q9Y5I2	PCDGA	Q9Y5H3	Yes	Yes	No	SIGNOR	SIGNOR:16697637
PCDA2	Q9Y5H9	PCDGA	Q9Y5H3	Yes	Yes	No	SIGNOR	SIGNOR:16697637

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Mass spectrometrySmall R sequencing (Illumi HiSeq 2000 (Solexa)R Sequencing	5	38343172 39363010 40222457 40595564 39025337

Sequence, Structure & Domains8

Sequences

Length

936

Mass

101,447

Sequence

MAAQRNRSKESKDCSGLVLLCLFFGIPWEAGARQISYSIPEELEKGSFVGNISKDLGLAPRELAERGVRIVSRGRTQLFSLNPRSGSLITAGRIDREELCAQSARCVVSFNILVEDRVKLFGIEIEVTDINDNAPKFQAENLDVKINENVAAGMRFPLPEAIDPDVGVNSLQSYQLSPNKHFSLRVQSRANGVKYPELVLEHSLDREEEAIHHLVLTASDGGDPLRSGTVLVSVTVFDANDNAPVFTLPEYRVSVPENLPVGTQLLTVTATDRDEGANGEVTYSFRKLPDTQLLKFQLNKYTGEIKISENLDYEETGFYEIEIQAEDGGAYLATAKVLITVEDVNDNSPELTITSLFSPVTEDSPLGTVVALLNVHDLDSEQNGQVTCSILAYLPFKLEKSIDSYYRLVIHRALDREQVSSYNITVTATDGGSPPLSTEAHFMLQVADINDNPPTFSQVSYFTYIPENNARGASIFSVTALDPDSKENAQIIYSLAEDTIQGVPLSSYISINSDTGVLYALRSFDYEQFHELQMQVTASDSGDPPLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDRDSGQNAWLSYRLLKASEPGLFAVGEHTGEVRTARALLDRDALKQSLVVAVQDHGQPPLSATVTLTVAVADSIPQVLADLGSFESPANSETSDLTLYLVVAVAAVSCVFLAFVIVLLAHRLRRWHKSRLLQASGGGLTGVSGSHFVGVDGVRAFLQTYSHEVSLTADSRKSHLIFPQPNYADTLISQESCEKNDPLSLLDDSKFPIEDTPLVPQAPPNTDWRFSQAQRPGTSGSQNGDDTGTWPNNQFDTEMLQAMILASASEAADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKAPAGGNGNKKKSGKKEKK

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9Y5H3-1; Sequence=Displayed; Name=2; Synonyms=Short; IsoId=Q9Y5H3-2; Sequence=VSP_008677, VSP_008678

Alternative Sequence

813..850; QAPPNTDWRFSQAQRPGTSGSQNGDDTGTWPNNQFDTE -> VSFIFIFTFVKKKKIGFYFEVCGMMVESVNAKTLMSRI (in isoform 2); 851..936; Missing (in isoform 2)

Domain & Motif Annotations

Compositional Bias

820..845; Polar residues; 926..936; Basic residues

Domain (FT)

33..137; Cadherin 1; 138..246; Cadherin 2; 247..351; Cadherin 3; 352..456; Cadherin 4; 457..566; Cadherin 5; 574..687; Cadherin 6

Region

806..845; Disordered; 906..936; Disordered

Clinical Relevance1

Antibody (3)

HPA008755 HPA010580 HPA077276

Supporting Publications6

PMID	Title	Abstract
33309826	Proteomic analysis of extracellular vesicles and conditioned medium from human adipose-derived stem/stromal cells and dermal fibroblasts.	No abstract available
36497184	Oxidative Stress and Extracellular Matrix Remodeling Are Signature Pathways of Extracellular Vesicles Released upon Morphine Exposure on Human Brain Microvascular Endothelial Cells.	No abstract available
37322475	Comprehensive profiling of extracellular vesicles in uveitis and scleritis enables biomarker discovery and mechanism exploration.	No abstract available
38207106	Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity.	No abstract available
40189497	Small extracellular vesicle-based one-step high-throughput microfluidic platform for epithelial ovarian cancer diagnosis.	No abstract available
41068253	Identification of plasma extracellular vesicle protein biomarkers in diabetic retinopathy progression.	No abstract available