Protein detail
PCDGA
Protocadherin gamma-A10 (PCDH-gamma-A10)
Entry name PCDGA | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 6 | Transmembrane count 1 | Protein classification Predicted membrane proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Protocadherin gamma-A10 (PCDH-gamma-A10)
Protein Class
Predicted membrane proteins
Transmembrane
697..717; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
PCDH-GAMMA-A10
Gene Description
Protocadherin gamma subfamily A, 10
Chromosome
5
Position
141412987-141512975
Supporting publications (n)
6
EVMP confidence score
0.50
Fluorescence & Localization
Tissue SpecificbrainCell SpecificBrain excitatory neuronsSingle-Nuclei Brain Specificcerebellar inhibitory
Function & Pathway
Cellular Component
Molecular Function
Biological Process (3)
Mediation Categories
Adhesion and uptake mediation
Relations & Evidence25
Ligand-Receptor Signaling (22)
22 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | CellChatDB | Yes | Yes | |||
| receptor | receptor | OmniPath | Yes | Yes | |||
| cell_surface_ligand | cell_surface_ligand | CellChatDB | Yes | Yes | |||
| cell_surface_ligand | cell_surface_ligand | OmniPath | Yes | Yes | |||
| protocadherin | cell_adhesion | HGNC | Yes | Yes | Yes | ||
| adhesion | adhesion | HGNC | Yes | Yes | Yes | ||
| cell_adhesion | cell_adhesion | Zhong2015 | Yes | Yes | Yes | ||
| icam | cell_adhesion | Zhong2015 | Yes | Yes | Yes | ||
| cell_adhesion | cell_adhesion | HGNC | Yes | Yes | Yes | ||
| adhesion | adhesion | OmniPath | Yes | Yes | Yes |
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Regulatory Interaction Network (2)
2 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| PCDAA | Q9Y5I2 | PCDGA | Q9Y5H3 | Yes | Yes | SIGNOR | SIGNOR:16697637 | |
| PCDA2 | Q9Y5H9 | PCDGA | Q9Y5H3 | Yes | Yes | SIGNOR | SIGNOR:16697637 |
Isolation & Detection Technology (1)
Sequence, Structure & Domains
Sequences
Length
936
Mass
101,447
Sequence
MAAQRNRSKESKDCSGLVLLCLFFGIPWEAGARQISYSIPEELEKGSFVGNISKDLGLAPRELAERGVRIVSRGRTQLFSLNPRSGSLITAGRIDREELCAQSARCVVSFNILVEDRVKLFGIEIEVTDINDNAPKFQAENLDVKINENVAAGMRFPLPEAIDPDVGVNSLQSYQLSPNKHFSLRVQSRANGVKYPELVLEHSLDREEEAIHHLVLTASDGGDPLRSGTVLVSVTVFDANDNAPVFTLPEYRVSVPENLPVGTQLLTVTATDRDEGANGEVTYSFRKLPDTQLLKFQLNKYTGEIKISENLDYEETGFYEIEIQAEDGGAYLATAKVLITVEDVNDNSPELTITSLFSPVTEDSPLGTVVALLNVHDLDSEQNGQVTCSILAYLPFKLEKSIDSYYRLVIHRALDREQVSSYNITVTATDGGSPPLSTEAHFMLQVADINDNPPTFSQVSYFTYIPENNARGASIFSVTALDPDSKENAQIIYSLAEDTIQGVPLSSYISINSDTGVLYALRSFDYEQFHELQMQVTASDSGDPPLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDRDSGQNAWLSYRLLKASEPGLFAVGEHTGEVRTARALLDRDALKQSLVVAVQDHGQPPLSATVTLTVAVADSIPQVLADLGSFESPANSETSDLTLYLVVAVAAVSCVFLAFVIVLLAHRLRRWHKSRLLQASGGGLTGVSGSHFVGVDGVRAFLQTYSHEVSLTADSRKSHLIFPQPNYADTLISQESCEKNDPLSLLDDSKFPIEDTPLVPQAPPNTDWRFSQAQRPGTSGSQNGDDTGTWPNNQFDTEMLQAMILASASEAADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKAPAGGNGNKKKSGKKEKK
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9Y5H3-1; Sequence=Displayed; Name=2; Synonyms=Short; IsoId=Q9Y5H3-2; Sequence=VSP_008677, VSP_008678
Alternative Sequence
813..850; QAPPNTDWRFSQAQRPGTSGSQNGDDTGTWPNNQFDTE -> VSFIFIFTFVKKKKIGFYFEVCGMMVESVNAKTLMSRI (in isoform 2); 851..936; Missing (in isoform 2)
Domain & Motif Annotations
Compositional Bias
820..845; Polar residues; 926..936; Basic residues
Domain (FT)
33..137; Cadherin 1; 138..246; Cadherin 2; 247..351; Cadherin 3; 352..456; Cadherin 4; 457..566; Cadherin 5; 574..687; Cadherin 6
Region
806..845; Disordered; 906..936; Disordered
Supporting Publications6
| PMID | Title | Related sentences |
|---|---|---|
| 33309826 | Proteomic analysis of extracellular vesicles and conditioned medium from human adipose-derived stem/stromal cells and dermal fibroblasts. | No related sentences available |
| 36497184 | Oxidative Stress and Extracellular Matrix Remodeling Are Signature Pathways of Extracellular Vesicles Released upon Morphine Exposure on Human Brain Microvascular Endothelial Cells. | No related sentences available |
| 37322475 | Comprehensive profiling of extracellular vesicles in uveitis and scleritis enables biomarker discovery and mechanism exploration. | No related sentences available |
| 38207106 | Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity. | No related sentences available |
| 40189497 | Small extracellular vesicle-based one-step high-throughput microfluidic platform for epithelial ovarian cancer diagnosis. | No related sentences available |
| 41068253 | Identification of plasma extracellular vesicle protein biomarkers in diabetic retinopathy progression. | No related sentences available |