Protein detail

PCDGA

Protocadherin gamma-A10 (PCDH-gamma-A10)

Protein symbol PCDGA	UniProt ID Q9Y5H3	EVMP score 0.63
Frequency 6	Transmembrane count 1	Protein classification Predicted membrane proteins

Basic Information

Protein Names

Protocadherin gamma-A10 (PCDH-gamma-A10)

Protein Class

Predicted membrane proteins

Transmembrane

697..717; Helical

Transmembrane Count

Ensembl

ENSG00000253846

Entrez Gene Symbol

PCDHGA10

Gene Synonym

PCDH-GAMMA-A10

Gene Description

Protocadherin gamma subfamily A, 10

Chromosome

Position

141412987-141512975

Frequency

EVMP Score

0.63

Fluorescence & Localization

Tissue SpecificbrainCell SpecificBrain excitatory neuronsSingle-Nuclei Brain Specificcerebellar inhibitory

Function & Pathway

Cellular Component

GO:0005886 plasma membrane

Molecular Function

GO:0005509 calcium ion binding

Biological Process

KEGG

hsa04519 Cadherin signaling

Mediation Categories

Adhesion and uptake mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

22 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
cell_surface	cell_surface	OmniPath	No	No	No	Yes	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	Yes	No

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Regulatory Interaction Network

2 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
PCDAA	Q9Y5I2	PCDGA	Q9Y5H3	Yes	Yes	No	SIGNOR	SIGNOR:16697637
PCDA2	Q9Y5H9	PCDGA	Q9Y5H3	Yes	Yes	No	SIGNOR	SIGNOR:16697637

Protein Complex Composition

0 records.

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Mass spectrometrySmall R sequencing (Illumi HiSeq 2000 (Solexa)R Sequencing	5	38343172 39363010 40222457 40595564 39025337

Sequence, Structure & Domains

Sequences

Length

936

Mass

101,447

Sequence

MAAQRNRSKESKDCSGLVLLCLFFGIPWEAGARQISYSIPEELEKGSFVGNISKDLGLAPRELAERGVRIVSRGRTQLFSLNPRSGSLITAGRIDREELCAQSARCVVSFNILVEDRVKLFGIEIEVTDINDNAPKFQAENLDVKINENVAAGMRFPLPEAIDPDVGVNSLQSYQLSPNKHFSLRVQSRANGVKYPELVLEHSLDREEEAIHHLVLTASDGGDPLRSGTVLVSVTVFDANDNAPVFTLPEYRVSVPENLPVGTQLLTVTATDRDEGANGEVTYSFRKLPDTQLLKFQLNKYTGEIKISENLDYEETGFYEIEIQAEDGGAYLATAKVLITVEDVNDNSPELTITSLFSPVTEDSPLGTVVALLNVHDLDSEQNGQVTCSILAYLPFKLEKSIDSYYRLVIHRALDREQVSSYNITVTATDGGSPPLSTEAHFMLQVADINDNPPTFSQVSYFTYIPENNARGASIFSVTALDPDSKENAQIIYSLAEDTIQGVPLSSYISINSDTGVLYALRSFDYEQFHELQMQVTASDSGDPPLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDRDSGQNAWLSYRLLKASEPGLFAVGEHTGEVRTARALLDRDALKQSLVVAVQDHGQPPLSATVTLTVAVADSIPQVLADLGSFESPANSETSDLTLYLVVAVAAVSCVFLAFVIVLLAHRLRRWHKSRLLQASGGGLTGVSGSHFVGVDGVRAFLQTYSHEVSLTADSRKSHLIFPQPNYADTLISQESCEKNDPLSLLDDSKFPIEDTPLVPQAPPNTDWRFSQAQRPGTSGSQNGDDTGTWPNNQFDTEMLQAMILASASEAADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKAPAGGNGNKKKSGKKEKK

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9Y5H3-1; Sequence=Displayed; Name=2; Synonyms=Short; IsoId=Q9Y5H3-2; Sequence=VSP_008677, VSP_008678

Alternative Sequence

813..850; QAPPNTDWRFSQAQRPGTSGSQNGDDTGTWPNNQFDTE -> VSFIFIFTFVKKKKIGFYFEVCGMMVESVNAKTLMSRI (in isoform 2); 851..936; Missing (in isoform 2)

3D Structural Models

Domain & Motif Annotations

Compositional Bias

820..845; Polar residues; 926..936; Basic residues

Domain (FT)

33..137; Cadherin 1; 138..246; Cadherin 2; 247..351; Cadherin 3; 352..456; Cadherin 4; 457..566; Cadherin 5; 574..687; Cadherin 6

Region

806..845; Disordered; 906..936; Disordered

Clinical Relevance

Antibody

HPA008755 HPA010580 HPA077276