Protein detail

PCDA8

Protocadherin alpha-8 (PCDH-alpha-8)

Entry name PCDA8	UniProt ID Q9Y5H6	EVMP confidence score 0.50
Supporting publications (n) 2	Transmembrane count 1	Protein classification Predicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Protocadherin alpha-8 (PCDH-alpha-8)

Protein Class

Predicted membrane proteins

Transmembrane

698..718; Helical

Transmembrane Count

Ensembl

ENSG00000204962

Entrez Gene Symbol

PCDHA8

Gene Description

Protocadherin alpha 8

Chromosome

Position

140841187-141012347

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization2

Tissue SpecificintestineCell SpecificEnterocytes

Function & Pathway4

Cellular Component

GO:0005886 plasma membrane

Molecular Function

GO:0005509 calcium ion binding

KEGG

hsa04519 Cadherin signaling

Mediation Categories

Adhesion and uptake mediation

Relations & Evidence28

Ligand-Receptor Signaling (26)

26 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
icam	cell_adhesion	Zhong2015	Yes	Yes	No	Yes	No
cell_adhesion	cell_adhesion	HGNC	Yes	Yes	No	Yes	No
adhesion	adhesion	OmniPath	Yes	Yes	No	Yes	No
cell_adhesion	cell_adhesion	OmniPath	Yes	Yes	No	Yes	No
transmembrane	transmembrane	UniProt_location	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_topology	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	Yes	No
transmembrane	transmembrane	LOCATE	No	No	No	Yes	No
transmembrane	transmembrane	OmniPath	No	No	No	Yes	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	Yes	No

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Regulatory Interaction Network (1)

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
PCDA8	Q9Y5H6	ITB1	P05556	Yes	Yes	No	SIGNOR	SIGNOR:16697637

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Western blottingELISA	4	38731868 28242843 37686366 37922300

Sequence, Structure & Domains9

Sequences

Length

950

Mass

103,051

Sequence

MDYHWRGELGSWRLLLLLLLLAAWKVGSGQLHYSVPEEAKHGTFVGRIAQDLGLELAELVPRLFRVASKRHRDLLEVSLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVDVEVKDVNDNPPVFRVKDQKLFVSESRMPDSRFPLEGASDADVGANSVLTYRLSSHDYFMLDVNSKNDENKLVELVLRKSLDREDAPAHHLFLTATDGGKPELTGTVQLLVTVLDVNDNAPTFEQSEYEVRIFENADNGTTVIKLNASDPDEGANGAISYSFNSLVETMVIDHFSIDRNTGEIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPVREDAQFGTVIALISVNDLDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRERVSAYELVVTARDGGSPSLWATASLSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERSLSSYISVHTESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLEPRVGGTGGAASKLVPRSVGAGHVVAKVRAVDADSGYNAWLSYELQPAASSPRIPFRVGLYTGEISTTRVLDEADSPRHRLLVLVKDHGEPALTATATVLVSLVESGQAPKASSRQSAGVLGPEAALVDVNVYLIIAICAVSSLLVLTLLLYTALRCSALPTEGGCRAGKPTLVCSSAVGSWSYSQQQPQRVCSGEGPPKTDLMAFSPCLPPDLGSVDVGEEQDLNVDHGLKPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9Y5H6-1; Sequence=Displayed; Name=2; IsoId=Q9Y5H6-2; Sequence=VSP_000686, VSP_000687

Alternative Sequence

799..814; PRQPNPDWRYSASLRA -> VSPFKFRTHKFYLWKL (in isoform 2); 815..950; Missing (in isoform 2)

Domain & Motif Annotations

Compositional Bias

909..923; Basic and acidic residues

Repeat

774..777; PXXP 1; 799..802; PXXP 2; 832..835; PXXP 3; 873..876; PXXP 4; 891..894; PXXP 5

Domain (FT)

30..133; Cadherin 1; 157..242; Cadherin 2; 243..350; Cadherin 3; 351..455; Cadherin 4; 456..565; Cadherin 5; 581..678; Cadherin 6

Region

774..894; 5 X 4 AA repeats of P-X-X-P; 830..950; Disordered

Clinical Relevance1

Antibody

HPA044585

Supporting Publications2

PMID	Title	Abstract
38113368	In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum.	No abstract available
38207106	Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity.	No abstract available