Protein detail
PCDA1
Protocadherin alpha-1 (PCDH-alpha-1)
Entry name PCDA1 | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 7 | Transmembrane count 1 | Protein classification Predicted membrane proteinsPredicted secreted proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information12
Protein Names
Protocadherin alpha-1 (PCDH-alpha-1)
Protein Class (2)
Predicted membrane proteinsPredicted secreted proteins
Protein Function
Predicted secreted proteins
Transmembrane
698..718; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Description
Protocadherin alpha 1
Chromosome
5
Position
140786136-141012347
Supporting publications (n)
7
EVMP confidence score
0.50
Fluorescence & Localization3
Tissue SpecificplacentaCell SpecificAlveolar cells type 1Single-Nuclei Brain Specificastrocyte
Function & Pathway6
Protein Function
Predicted secreted proteins
Cellular Component (3)
Molecular Function
Biological Process (3)
Mediation Categories
Adhesion and uptake mediation
Relations & Evidence33
Ligand-Receptor Signaling (31)
31 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| plasma_membrane | plasma_membrane | UniProt_location | No | No | Yes | Yes | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | Yes | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | Membranome | No | No | Yes | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | OmniPath | No | No | Yes | Yes | No |
| secreted | secreted | UniProt_keyword | No | No | Yes | Yes | No |
| secreted | secreted | UniProt_location | No | No | Yes | Yes | No |
| secreted | secreted | HPA_secretome | No | No | Yes | Yes | No |
| secreted | secreted | OmniPath | No | No | Yes | Yes | No |
| cell_surface | cell_surface | Surfaceome | No | No | Yes | Yes | No |
| cell_surface | cell_surface | OmniPath | No | No | Yes | Yes | No |
Regulatory Interaction Network (1)
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| PCDA1 | Q9Y5I3 | ITB1 | P05556 | Yes | Yes | No | SIGNOR | SIGNOR:16697637 |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Size Exclusion Chromatography | Mass spectrometry | 1 | 38343172 |
Sequence, Structure & Domains9
Sequences
Length
950
Mass
102,952
Sequence
MVFSRRGGLGARDLLLWLLLLAAWEVGSGQLHYSIPEEAKHGTFVGRVAQDLGLELAELVPRLFRVASKTHRDLLEVNLQNGILFVNSRIDREELCQWSAECSIHLELIADRPLQVFHVEVKVKDINDNPPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSDYFSLDVEASDELSKSLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDNAPLFDQAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEKFKVDSSSGEIRLIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVTSLYLPIREDAPLSTVIALITVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRESLSVYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERALSNYVSVHAESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRVGGTIGAVSELVPRLVGAGHVVAKVRAVDADSGYNAWLSYELQPAAGGARIPFRVGLYTGEISTTRVLDEADLSRYRLLVLVKDHGEPALTATATVLVSLVESGQAPKASSRASVGVAGPEAALVDVNVYLIIAICAVSSLLVLTLLLYTALRCSVPPTEGAYVPGKPTLVCSSALGSWSNSQQRRQRVCSSEGPPKTDLMAFSPGLSPSLNTSERNEQPEANLDLSGNPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ
Alternative Products
Event=Alternative splicing; Named isoforms=3; Comment=Additional isoforms seem to exist.; Name=1; IsoId=Q9Y5I3-1; Sequence=Displayed; Name=2; IsoId=Q9Y5I3-2; Sequence=VSP_000670; Name=3; IsoId=Q9Y5I3-3; Sequence=VSP_000671, VSP_000672
Alternative Sequence
535..798; Missing (in isoform 2); 799..807; PRQPNPDWR -> VSPTFEFWL (in isoform 3); 808..950; Missing (in isoform 3)
Domain & Motif Annotations
Compositional Bias
909..923; Basic and acidic residues
Repeat
734..737; PXXP 1; 799..802; PXXP 2; 832..835; PXXP 3; 873..876; PXXP 4; 891..894; PXXP 5
Domain (FT)
30..133; Cadherin 1; 157..242; Cadherin 2; 243..350; Cadherin 3; 351..455; Cadherin 4; 456..565; Cadherin 5; 588..678; Cadherin 6
Region
734..894; 5 X 4 AA repeats of P-X-X-P; 752..808; Disordered; 828..856; Disordered; 871..890; Disordered; 900..950; Disordered
Clinical Relevance1
Antibody
Supporting Publications7
| PMID | Title | Abstract |
|---|---|---|
| 22808001 | Biochemical and physical characterisation of urinary nanovesicles following CHAPS treatment. | No abstract available |
| 25776846 | Human thymic epithelial primary cells produce exosomes carrying tissue-restricted antigens. | No abstract available |
| 2780759 | The optimal processing of plasma samples for the determination of bicyclo-PGE in patients with malignant maxillofacial tumors. | No abstract available |
| 28211531 | Proteomic analysis of urinary extracellular vesicles from high Gleason score prostate cancer. | No abstract available |
| 28240915 | Quantitative Proteomic Analysis of Serum Exosomes from Patients with Locally Advanced Pancreatic Cancer Undergoing Chemoradiotherapy. | No abstract available |
| 30232403 | Proteomics study of human cord blood reticulocyte-derived exosomes. | No abstract available |
| 33169421 | A novel method of high-purity extracellular vesicle enrichment from microliter-scale human serum for proteomic analysis. | No abstract available |