Protein detail

SRPRB

Signal recognition particle receptor subunit beta (SR-beta) (Protein APMCF1)

Entry name SRPRB	UniProt ID Q9Y5M8	EVMP confidence score 0.50
Supporting publications (n) 4	Transmembrane count 1	Protein classification Essential proteinsPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information12

Protein Names

Signal recognition particle receptor subunit beta (SR-beta) (Protein APMCF1)

Protein Class (2)

Essential proteinsPredicted membrane proteins

Transmembrane

37..57; Helical

Transmembrane Count

Ensembl

ENSG00000144867

Entrez Gene Symbol

SRPRB

Gene Synonym (2)

APMCF1SR-beta

Gene Description

SRP receptor subunit beta

Chromosome

Position

133784023-133825772

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization4

Tissue SpecificesophagusCell SpecificColonocytesSingle-Nuclei Brain Specificmammillary body

Function & Pathway6

Cellular Component (5)

Molecular Function

GO:0005525 GTP binding

Biological Process (3)

KEGG

hsa03060 Protein export

Reactome (5)

Mediation Categories

Metabolism mediation

Relations & Evidence23

Ligand-Receptor Signaling (15)

15 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
transmembrane	transmembrane	UniProt_location	No	No	No	No	No
transmembrane	transmembrane	UniProt_topology	No	No	No	No	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	No	No
transmembrane_predicted	transmembrane	OmniPath	No	No	No	No	No
transmembrane	transmembrane	TopDB	No	No	No	No	No
transmembrane	transmembrane	LOCATE	No	No	No	No	No

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Regulatory Interaction Network (1)

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
SRP54	P61011	SRPRB	Q9Y5M8	Yes	Yes	No	SIGNOR	SIGNOR:30649417

Protein Complex Composition (6)

6 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
signal recognition particle receptor complex	SRPRA SRPRB	P08240 Q9Y5M8	1:1	hu.MAPhu.MAP2CompleatComplexPortal	PDB:2fh5intact:EBI-12506088Compleat:HC1532	14755292 10859309 9679135
	EIF6 LSM2 LSM3 LSM4 LSM6 LSM7 LSM8 MEPCE PRPF3 PRPF4 SART3 SNRPD2 SRPRB	O43172 O43395 O95777 P56537 P62310 P62312 P62316 Q15020 Q7L2J0 Q9UK45 Q9Y333 Q9Y4Z0 Q9Y5M8	1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC7142
	CHM CHTF18 POLA1 POLA2 POLE PRIM1 PRIM2 SRPRA SRPRB UBC	P08240 P09884 P0CG48 P24386 P49642 P49643 Q07864 Q14181 Q8WVB6 Q9Y5M8	1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC8544
	COX5A DHRS7 SRPRA SRPRB THEM6	P08240 P20674 Q8WUY1 Q9Y394 Q9Y5M8	0:0:0:0:0	hu.MAP2
	ARL8B SRPRA SRPRB THEM6 TMX2	P08240 Q8WUY1 Q9NVJ2 Q9Y320 Q9Y5M8	0:0:0:0:0	hu.MAP2
	MIA2 SRPRA SRPRB	P08240 Q96PC5 Q9Y5M8	0:0:0	hu.MAP

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Mass spectrometry	2	32795414 39940641

Sequence, Structure & Domains6

Sequences

Length

271

Mass

29,702

Sequence

MASADSRRVADGGGAGGTFQPYLDTLRQELQQTDPTLLSVVVAVLAVLLTLVFWKLIRSRRSSQRAVLLVGLCDSGKTLLFVRLLTGLYRDTQTSITDSCAVYRVNNNRGNSLTLIDLPGHESLRLQFLERFKSSARAIVFVVDSAAFQREVKDVAEFLYQVLIDSMGLKNTPSFLIACNKQDIAMAKSAKLIQQQLEKELNTLRVTRSAAPSTLDSSSTAPAQLGKKGKEFEFSQLPLKVEFLECSAKGGRGDVGSADIQDLEKWLAKIA

3D Structural Models

3D Structure

Electron microscopy (1)

Domain & Motif Annotations

Protein Families

SRP receptor beta subunit family

Sequence Similarities

Belongs to the SRP receptor beta subunit family.

Clinical Relevance5

Drugs

DEHYDRATED ALCOHOL

Antibody

HPA011173

Interaction Protein (7)

ENSG00000106803ENSG00000127022ENSG00000138942ENSG00000165650ENSG00000168818ENSG00000170310ENSG00000182934

Interaction Count

Interaction Dataset (3)

biogrid_opencellbiogrid_bioplexbiogrid_opencell_bioplex

Supporting Publications4

PMID	Title	Abstract
27086912	Comparative proteomics of exosomes secreted by tumoral Jurkat T cells and normal human T cell blasts unravels a potential tumorigenic role for valosin-containing protein.	No abstract available
27821849	Detailed Analysis of Protein Topology of Extracellular Vesicles-Evidence of Unconventional Membrane Protein Orientation.	No abstract available
31382537	An Insight into the Proteome of Uveal Melanoma-Derived Ectosomes Reveals the Presence of Potentially Useful Biomarkers.	No abstract available
38716512	Assessment of urine sample collection and processing variables for extracellular vesicle-based proteomics.	No abstract available