Protein detail
MMP24
Matrix metalloproteinase-24 (MMP-24) (EC 3.4.24.-) (Membrane-type matrix metalloproteinase 5) (MT-MMP 5) (MTMMP5) (Membrane-type-5 matrix metalloproteinase) (MT5-MMP) (MT5MMP) [Cleaved into: Processed matrix metalloproteinase-24]
Entry name MMP24 | UniProt ID | EVMP score 0.38 |
Frequency 4 | Transmembrane count 1 | Protein classification EnzymesPredicted membrane proteinsPredicted secreted proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Matrix metalloproteinase-24 (MMP-24) (EC 3.4.24.-) (Membrane-type matrix metalloproteinase 5) (MT-MMP 5) (MTMMP5) (Membrane-type-5 matrix metalloproteinase) (MT5-MMP) (MT5MMP) [Cleaved into: Processed matrix metalloproteinase-24]
Protein Class
EnzymesPredicted membrane proteinsPredicted secreted proteins
Protein Function
- Peptidases:Metallopeptidases
- Enzymes
- Predicted secreted proteins
Transmembrane
603..623; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
MT5-MMP
Gene Description
Matrix metallopeptidase 24
Chromosome
20
Position
35226690-35276998
Frequency
4
EVMP Score
0.38
Fluorescence & Localization
Function & Pathway
Protein Function
- Peptidases:Metallopeptidases
- Enzymes
- Predicted secreted proteins
Cellular Component
Molecular Function
Biological Process
KEGG
- hsa04928 Parathyroid hormone synthesis
- secretion and action
Reactome
Mediation Categories
Adhesion and uptake mediationFusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
32 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| ecm | ecm | MatrixDB | Yes | No | Yes | Yes | No |
| ecm | ecm | CellCellInteractions | Yes | No | Yes | Yes | No |
| ecm | ecm | OmniPath | Yes | No | Yes | Yes | No |
| intracellular | intracellular | ComPPI | No | No | Yes | Yes | No |
| intracellular | intracellular | GO_Intercell | No | No | Yes | Yes | No |
| intracellular | intracellular | UniProt_location | No | No | Yes | Yes | No |
| intracellular | intracellular | OmniPath | No | No | Yes | Yes | No |
| ecm_regulator | ecm_regulator | Matrisome | Yes | No | Yes | Yes | No |
| ecm_regulator | ecm_regulator | OmniPath | Yes | No | Yes | Yes | No |
| m10_metallopeptidase | cell_surface_peptidase | OmniPath | Yes | No | Yes | Yes | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Sequence, Structure & Domains
Sequences
Length
645
Mass
73,231
Sequence
MPRSRGGRAAPGPPPPPPPPGQAPRWSRWRVPGRLLLLLLPALCCLPGAARAAAAAAGAGNRAAVAVAVARADEAEAPFAGQNWLKSYGYLLPYDSRASALHSAKALQSAVSTMQQFYGIPVTGVLDQTTIEWMKKPRCGVPDHPHLSRRRRNKRYALTGQKWRQKHITYSIHNYTPKVGELDTRKAIRQAFDVWQKVTPLTFEEVPYHEIKSDRKEADIMIFFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNANHDGNDLFLVAVHELGHALGLEHSSDPSAIMAPFYQYMETHNFKLPQDDLQGIQKIYGPPAEPLEPTRPLPTLPVRRIHSPSERKHERQPRPPRPPLGDRPSTPGTKPNICDGNFNTVALFRGEMFVFKDRWFWRLRNNRVQEGYPMQIEQFWKGLPARIDAAYERADGRFVFFKGDKYWVFKEVTVEPGYPHSLGELGSCLPREGIDTALRWEPVGKTYFFKGERYWRYSEERRATDPGYPKPITVWKGIPQAPQGAFISKEGYYTYFYKGRDYWKFDNQKLSVEPGYPRNILRDWMGCNQKEVERRKERRLPQDDVDIMVTINDVPGSVNAVAVVIPCILSLCILVLVYTIFQFKNKTGPQPVTYYKRPVQEWV
3D Structural Models
Domain & Motif Annotations
Compositional Bias
1..10; Low complexity; 11..22; Pro residues; 329..341; Pro residues; 349..359; Basic and acidic residues
Repeat
377..425; Hemopexin 1; 426..471; Hemopexin 2; 473..521; Hemopexin 3; 522..569; Hemopexin 4
Motif
137..144; Cysteine switch; 643..645; PDZ-binding
Domain (CC)
The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.; DOMAIN: The PDZ-binding motif (also named EWV motif) is required for interaction with PDZ domains of APBA3 and recycling through the trans-Golgi network.
Region
1..26; Disordered; 323..380; Disordered
Protein Families
Peptidase M10A family
Sequence Similarities
Belongs to the peptidase M10A family.