Protein detail

TRPV2

Transient receptor potential cation channel subfamily V member 2 (TrpV2) (Osm-9-like TRP channel 2) (OTRPC2) (Vanilloid receptor-like protein 1) (VRL-1)

Protein symbol TRPV2	UniProt ID Q9Y5S1	EVMP score 0.63
Frequency 10	Transmembrane count 6	Protein classification Predicted intracellular proteinsPredicted membrane proteinsTransporters

Basic Information

Protein Names

Transient receptor potential cation channel subfamily V member 2 (TrpV2) (Osm-9-like TRP channel 2) (OTRPC2) (Vanilloid receptor-like protein 1) (VRL-1)

Protein Class

Predicted intracellular proteinsPredicted membrane proteinsTransporters

Protein Function

Transporters:Transporter channels and pores
Predicted intracellular proteins

Transmembrane

391..409; Helical; Name=1; 430..452; Helical; Name=2; 469..487; Helical; Name=3; 494..514; Helical; Name=4; 535..556; Helical; Name=5; 621..641; Helical; Name=6

Transmembrane Count

Ensembl

ENSG00000187688

Entrez Gene Symbol

TRPV2

Gene Synonym

VRLVRL-1VRL1

Gene Description

Transient receptor potential cation channel subfamily V member 2

Chromosome

Position

16415571-16437003

Frequency

EVMP Score

0.63

Fluorescence & Localization

Cell SpecificAlveolar cells type 2Blood Cell Specificneutrophil

Function & Pathway

Protein Function

Transporters:Transporter channels and pores
Predicted intracellular proteins

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Mediation Categories

Fusion and delivery mediationMetabolism mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

35 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	OmniPath	No	Yes	No	Yes	No
extracellular	extracellular	OmniPath	No	No	No	Yes	No
intracellular	intracellular	LOCATE	No	No	No	Yes	No
intracellular	intracellular	GO_Intercell	No	No	No	Yes	No
intracellular	intracellular	UniProt_location	No	No	No	Yes	No
intracellular	intracellular	OmniPath	No	No	No	Yes	No
transporter	transporter	Surfaceome	No	Yes	No	Yes	No
trp_channels	transporter	Surfaceome	No	Yes	No	Yes	No
channels	transporter	Surfaceome	No	Yes	No	Yes	No
ion_channel	ion_channel	DGIdb	No	Yes	No	Yes	No

Page 1 of 4Next

Regulatory Interaction Network

0 records.

Protein Complex Composition

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	TRPV2	Q9Y5S1	2	PDB	PDB:2f37

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow Filtration	Mass spectrometry	2	40595564 39277144

Sequence, Structure & Domains

Sequences

Length

764

Mass

85,981

Sequence

MTSPSSSPVFRLETLDGGQEDGSEADRGKLDFGSGLPPMESQFQGEDRKFAPQIRVNLNYRKGTGASQPDPNRFDRDRLFNAVSRGVPEDLAGLPEYLSKTSKYLTDSEYTEGSTGKTCLMKAVLNLKDGVNACILPLLQIDRDSGNPQPLVNAQCTDDYYRGHSALHIAIEKRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAACTKQWDVVSYLLENPHQPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYDGLLQAGARLCPTVQLEDIRNLQDLTPLKLAAKEGKIEIFRHILQREFSGLSHLSRKFTEWCYGPVRVSLYDLASVDSCEENSVLEIIAFHCKSPHRHRMVVLEPLNKLLQAKWDLLIPKFFLNFLCNLIYMFIFTAVAYHQPTLKKQAAPHLKAEVGNSMLLTGHILILLGGIYLLVGQLWYFWRRHVFIWISFIDSYFEILFLFQALLTVVSQVLCFLAIEWYLPLLVSALVLGWLNLLYYTRGFQHTGIYSVMIQKVILRDLLRFLLIYLVFLFGFAVALVSLSQEAWRPEAPTGPNATESVQPMEGQEDEGNGAQYRGILEASLELFKFTIGMGELAFQEQLHFRGMVLLLLLAYVLLTYILLLNMLIALMSETVNSVATDSWSIWKLQKAISVLEMENGYWWCRKKQRAGVMLTVGTKPDGSPDERWCFRVEEVNWASWEQTLPTLCEDPSGAGVPRTLENPVLASPPKEDEDGASEENYVPVQLLQSN

3D Structural Models

Turn

113..115; 159..163

Helix

76..84; 88..91; 94..101; 108..110; 119..125; 135..145; 151..153; 166..172; 176..184; 196..198; 212..218; 222..230; 248..255; 260..280; 286..288; 297..303; 307..315

3D Structure

X-ray crystallography (1)

Domain & Motif Annotations

Repeat

72..114; ANK 1; 115..161; ANK 2; 162..207; ANK 3; 208..243; ANK 4; 244..292; ANK 5; 293..319; ANK 6

Region

1..388; Required for interaction with SLC50A1; 1..46; Disordered; 562..585; Disordered; 725..756; Disordered

Protein Families

Transient receptor (TC 1.A.4) family
TrpV subfamily
TRPV2 sub-subfamily

Sequence Similarities

Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV2 sub-subfamily.

Clinical Relevance

Antibody

HPA044993