Protein detail

CSAD

Cysteine sulfinic acid decarboxylase (EC 4.1.1.29) (Aspartate 1-decarboxylase) (EC 4.1.1.11) (Cysteine-sulfinate decarboxylase) (Sulfinoalanine decarboxylase)

Protein symbol CSAD	UniProt ID Q9Y600	EVMP score 0.38
Frequency 1	Transmembrane count	Protein classification EnzymesMetabolic proteinsPlasma proteinsPredicted intracellular proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Cysteine sulfinic acid decarboxylase (EC 4.1.1.29) (Aspartate 1-decarboxylase) (EC 4.1.1.11) (Cysteine-sulfinate decarboxylase) (Sulfinoalanine decarboxylase)

Protein Class

EnzymesMetabolic proteinsPlasma proteinsPredicted intracellular proteins

Protein Function

Enzymes
Predicted intracellular proteins
ENZYME proteins:Lyases

Ensembl

ENSG00000139631

Entrez Gene Symbol

CSAD

Gene Synonym

CSDPCAP

Gene Description

Cysteine sulfinic acid decarboxylase

Chromosome

Position

53157663-53180925

Frequency

EVMP Score

0.38

Fluorescence & Localization

Tissue Specificblood vesselCell SpecificCardiomyocytesSingle-Nuclei Brain Specificvascular associated smooth muscle cell

Function & Pathway

Protein Function

Enzymes
Predicted intracellular proteins
ENZYME proteins:Lyases

Cellular Component

GO:0005737 cytoplasm

Molecular Function

Biological Process

KEGG

Reactome

Mediation Categories

Metabolism mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

3 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Regulatory Interaction Network

0 records.

Protein Complex Composition

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	CSAD	Q9Y600	2	PDB	PDB:2jis

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometryWestern blottingELISA	10	36064647 38113368 41068253 33592500 33309826 40840701 31805958 34576246 37204515 39001700

Sequence, Structure & Domains

Sequences

Length

493

Mass

55,023

Sequence

MADSEALPSLAGDPVAVEALLRAVFGVVVDEAIQKGTSVSQKVCEWKEPEELKQLLDLELRSQGESQKQILERCRAVIRYSVKTGHPRFFNQLFSGLDPHALAGRIITESLNTSQYTYEIAPVFVLMEEEVLRKLRALVGWSSGDGIFCPGGSISNMYAVNLARYQRYPDCKQRGLRTLPPLALFTSKECHYSIQKGAAFLGLGTDSVRVVKADERGKMVPEDLERQIGMAEAEGAVPFLVSATSGTTVLGAFDPLEAIADVCQRHGLWLHVDAAWGGSVLLSQTHRHLLDGIQRADSVAWNPHKLLAAGLQCSALLLQDTSNLLKRCHGSQASYLFQQDKFYDVALDTGDKVVQCGRRVDCLKLWLMWKAQGDQGLERRIDQAFVLARYLVEEMKKREGFELVMEPEFVNVCFWFVPPSLRGKQESPDYHERLSKVAPVLKERMVKEGSMMIGYQPHGTRGNFFRVVVANSALTCADMDFLLNELERLGQDL

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=Long; IsoId=Q9Y600-1; Sequence=Displayed; Name=2; Synonyms=Short; IsoId=Q9Y600-2; Sequence=VSP_001307; Name=3; IsoId=Q9Y600-3; Sequence=VSP_039002

Alternative Sequence

1; M -> MSIPLKSSFLLSYLCTLPPALLSREILM (in isoform 3); 43..189; Missing (in isoform 2)

3D Structural Models

Turn

32..34; 118..120; 248..250; 284..286

Helix

14..31; 35..37; 49..56; 67..80; 99..111; 122..139; 152..167; 171..174; 176..178; 193..200; 205..207; 221..233; 256..266; 277..282; 287..290; 293..295; 324..329; 345..347; 350..352; 362..396; 419..421; 430..435; 437..448; 476..490

Beta Strand

89..93; 145..151; 182..187; 208..211; 237..246; 269..274; 297..301; 314..319; 401..405; 408..416; 452..458; 461..468

3D Structure

X-ray crystallography (1)

Domain & Motif Annotations

Protein Families

Group II decarboxylase family

Sequence Similarities

Belongs to the group II decarboxylase family.

Clinical Relevance

Antibody

HPA039487 HPA079296