Protein detail

CSAD

Cysteine sulfinic acid decarboxylase (EC 4.1.1.29) (Aspartate 1-decarboxylase) (EC 4.1.1.11) (Cysteine-sulfinate decarboxylase) (Sulfinoalanine decarboxylase)

Entry name CSAD	UniProt ID Q9Y600	EVMP confidence score 0.53
Supporting publications (n) 1	Transmembrane count	Protein classification EnzymesMetabolic proteinsPlasma proteinsPredicted intracellular proteins

Basic Information

Protein Names

Cysteine sulfinic acid decarboxylase (EC 4.1.1.29) (Aspartate 1-decarboxylase) (EC 4.1.1.11) (Cysteine-sulfinate decarboxylase) (Sulfinoalanine decarboxylase)

Protein Class (4)

EnzymesMetabolic proteinsPlasma proteinsPredicted intracellular proteins

Protein Function (3)

Enzymes
Predicted intracellular proteins
ENZYME proteins:Lyases

Ensembl

ENSG00000139631

Entrez Gene Symbol

CSAD

Gene Synonym (2)

CSDPCAP

Gene Description

Cysteine sulfinic acid decarboxylase

Chromosome

Position

53157663-53180925

Supporting publications (n)

EVMP confidence score

0.53

Fluorescence & Localization

Tissue Specificblood vesselCell SpecificCardiomyocytesSingle-Nuclei Brain Specificvascular associated smooth muscle cell

Function & Pathway

Protein Function (3)

Enzymes
Predicted intracellular proteins
ENZYME proteins:Lyases

Cellular Component

GO:0005737 cytoplasm

Molecular Function (3)

Biological Process (3)

KEGG (4)

Reactome (3)

Mediation Categories

Metabolism mediation

Relations & Evidence5

Ligand-Receptor Signaling (3)

3 records.

Category	Parent	Database
intracellular	intracellular	ComPPI
intracellular	intracellular	GO_Intercell
intracellular	intracellular	OmniPath

Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	CSAD	Q9Y600	2	PDB	PDB:2jis

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometryWestern blottingELISA	10	36064647 38113368 41068253 33592500 33309826 40840701 31805958 34576246 37204515 39001700

Sequence, Structure & Domains

Sequences

Length

493

Mass

55,023

Sequence

MADSEALPSLAGDPVAVEALLRAVFGVVVDEAIQKGTSVSQKVCEWKEPEELKQLLDLELRSQGESQKQILERCRAVIRYSVKTGHPRFFNQLFSGLDPHALAGRIITESLNTSQYTYEIAPVFVLMEEEVLRKLRALVGWSSGDGIFCPGGSISNMYAVNLARYQRYPDCKQRGLRTLPPLALFTSKECHYSIQKGAAFLGLGTDSVRVVKADERGKMVPEDLERQIGMAEAEGAVPFLVSATSGTTVLGAFDPLEAIADVCQRHGLWLHVDAAWGGSVLLSQTHRHLLDGIQRADSVAWNPHKLLAAGLQCSALLLQDTSNLLKRCHGSQASYLFQQDKFYDVALDTGDKVVQCGRRVDCLKLWLMWKAQGDQGLERRIDQAFVLARYLVEEMKKREGFELVMEPEFVNVCFWFVPPSLRGKQESPDYHERLSKVAPVLKERMVKEGSMMIGYQPHGTRGNFFRVVVANSALTCADMDFLLNELERLGQDL

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=Long; IsoId=Q9Y600-1; Sequence=Displayed; Name=2; Synonyms=Short; IsoId=Q9Y600-2; Sequence=VSP_001307; Name=3; IsoId=Q9Y600-3; Sequence=VSP_039002

Alternative Sequence

1; M -> MSIPLKSSFLLSYLCTLPPALLSREILM (in isoform 3); 43..189; Missing (in isoform 2)

3D Structural Models

Turn

32..34; 118..120; 248..250; 284..286

Helix

14..31; 35..37; 49..56; 67..80; 99..111; 122..139; 152..167; 171..174; 176..178; 193..200; 205..207; 221..233; 256..266; 277..282; 287..290; 293..295; 324..329; 345..347; 350..352; 362..396; 419..421; 430..435; 437..448; 476..490

Beta Strand

89..93; 145..151; 182..187; 208..211; 237..246; 269..274; 297..301; 314..319; 401..405; 408..416; 452..458; 461..468

3D Structure

X-ray crystallography (1)

Domain & Motif Annotations

Protein Families

Group II decarboxylase family

Sequence Similarities

Belongs to the group II decarboxylase family.

Clinical Relevance

Antibody (2)

HPA039487 HPA079296

Supporting Publications1

PMID	Title	Related sentences
32384937	Alzheimer's disease progression characterized by alterations in the molecular profiles and biogenesis of brain extracellular vesicles.	No related sentences available