Protein detail
JAM1
Junctional adhesion molecule A (JAM-A) (Junctional adhesion molecule 1) (JAM-1) (Platelet F11 receptor) (Platelet adhesion molecule 1) (PAM-1) (CD antigen CD321)
Protein symbol JAM1 | UniProt ID | EVMP score 0.25 |
Frequency 1 | Transmembrane count 1 | Protein classification CD markersPlasma proteinsPredicted membrane proteins |
Basic Information
Protein Names
Junctional adhesion molecule A (JAM-A) (Junctional adhesion molecule 1) (JAM-1) (Platelet F11 receptor) (Platelet adhesion molecule 1) (PAM-1) (CD antigen CD321)
Protein Class
CD markersPlasma proteinsPredicted membrane proteins
Protein Function
CD markers
Transmembrane
239..259; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
CD321JAM-1JAM-AJAM1JAMAJCAMPAM-1
Gene Description
F11 receptor
Chromosome
1
Position
160995211-161021343
Frequency
1
EVMP Score
0.25
Fluorescence & Localization
Function & Pathway
Protein Function
CD markers
Cellular Component
Molecular Function
Biological Process
KEGG
Reactome
- R-hsa-1500931 cell cell communication
- R-hsa-446728 cell junction organization
- R-hsa-202733 cell surface interactions at the vascular wall
- R-hsa-1474244 extracellular matrix organization
- R-hsa-109582 hemostasis
- R-hsa-216083 integrin cell surface interactions
- R-hsa-9006936 signaling by tgfb family members
- R-hsa-170834 signaling by tgf beta receptor complex
- R-hsa-2173791 tgf beta receptor signaling in emt epithelial to mesenchymal transition
- R-hsa-420029 tight junction interactions
Canonical Pathways
- M3008 Naba ecm glycoproteins
- M5884 Naba core matrisome
- M5889 Naba matrisome
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
5 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| F11R | PRKCA | P17252 | S | 284 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | SIGNOR:11027562ProtMapper:11027562 |
| F11R | PRKCA | P17252 | T | 92 | phosphorylation | MIMPHPRD_MIMPSIGNORProtMapperKEASIGNOR_ProtMapper | SIGNOR:7646439KEA:7646439ProtMapper:7646439 |
| F11R | PRKCA | P17252 | T | 70 | phosphorylation | MIMPHPRD_MIMPKEA | KEA:7646439 |
| F11R | CSNK2A1 | P68400 | S | 34 | phosphorylation | MIMPHPRD_MIMPKEA | KEA:7646439 |
| F11R | SRC | P12931 | Y | 280 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:30625033 |
Ligand-Receptor Signaling
43 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| extracellular | extracellular | OmniPath | No | No | No | Yes | No |
| intracellular | intracellular | LOCATE | No | No | No | Yes | No |
| intracellular | intracellular | ComPPI | No | No | No | Yes | No |
| intracellular | intracellular | GO_Intercell | No | No | No | Yes | No |
| intracellular | intracellular | OmniPath | No | No | No | Yes | No |
| cell_surface_ligand | cell_surface_ligand | connectomeDB2020 | Yes | No | No | Yes | No |
| cell_surface_ligand | cell_surface_ligand | CellChatDB | Yes | No | No | Yes | No |
| cell_surface_ligand | cell_surface_ligand | Baccin2019 | Yes | No | No | Yes | No |
| cell_surface_ligand | cell_surface_ligand | OmniPath | Yes | No | No | Yes | No |
| ig_like | cell_adhesion | HGNC | Yes | Yes | No | Yes | No |
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Regulatory Interaction Network
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| KPCA | P17252 | JAM1 | Q9Y624 | Yes | Yes | No | WangphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAHPRD_KEASIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | SIGNOR:7646439SIGNOR:11027562PhosphoSite:11027562HPRD:7646439ProtMapper:11027562KEA:7646439ProtMapper:7646439 |
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 27894104 |
Sequence, Structure & Domains
Sequences
Length
299
Mass
32,583
Sequence
MGTKAQVERKLLCLFILAILLCSLALGSVTVHSSEPEVRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAVLTCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNGYGTPMTSNAVRMEAVERNVGVIVAAVLVTLILLGILVFGIWFAYSRGHFDRTKKGTSSKKVIYSQPSARSEGEFKQTSSFLV
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9Y624-1; Sequence=Displayed; Name=2; IsoId=Q9Y624-2; Sequence=VSP_056218
Alternative Sequence
81..129; Missing (in isoform 2)
3D Structural Models
Turn
81..86; 192..194
Helix
101..103; 204..206
Beta Strand
30..32; 36..41; 47..49; 51..54; 56..66; 69..75; 76..79; 88..90; 93..95; 105..113; 123..125; 128..130; 140..144; 149..151; 163..168; 177..182; 197..201; 210..215; 217..219; 230..232
3D Structure
X-ray crystallography (4)
Domain & Motif Annotations
Domain (CC)
The Ig-like V-type 2 domain is necessary and sufficient for interaction with integrin alpha-L/beta-2..
Domain (FT)
28..125; Ig-like V-type 1; 135..228; Ig-like V-type 2
Protein Families
Immunoglobulin superfamily
Sequence Similarities
Belongs to the immunoglobulin superfamily.