Protein detail
NPTN
Neuroplastin (Stromal cell-derived receptor 1) (SDR-1)
Protein symbol NPTN | UniProt ID | EVMP score 0.38 |
Frequency 1 | Transmembrane count 1 | Protein classification Predicted intracellular proteinsPredicted membrane proteinsTransporters |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Neuroplastin (Stromal cell-derived receptor 1) (SDR-1)
Protein Class
Predicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function
- Predicted intracellular proteins
- Transporters:Accessory Factors Involved in Transport
Transmembrane
340..360; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
GP55GP65np55np65SDFR1SDR1
Gene Description
Neuroplastin
Chromosome
15
Position
73560014-73634134
Frequency
1
EVMP Score
0.38
Fluorescence & Localization
Function & Pathway
Protein Function
- Predicted intracellular proteins
- Transporters:Accessory Factors Involved in Transport
Cellular Component
Molecular Function
Biological Process
Reactome
Mediation Categories
Adhesion and uptake mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
39 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| plasma_membrane | plasma_membrane | Cellinker | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | Membranome | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | CSPA | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | OmniPath | No | No | No | Yes | No |
| cell_surface | cell_surface | Surfaceome | No | No | No | Yes | No |
| cell_surface | cell_surface | OmniPath | No | No | No | Yes | No |
| basigin | ligand | HGNC | Yes | No | No | Yes | No |
| ligand | ligand | HGNC | Yes | No | No | Yes | No |
| ligand | ligand | OmniPath | Yes | No | No | Yes | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
Sequence, Structure & Domains
Sequences
Length
398
Mass
44,387
Sequence
MSGSSLPSALALSLLLVSGSLLPGPGAAQNAGFVKSPMSETKLTGDAFELYCDVVGSPTPEIQWWYAEVNRAESFRQLWDGARKRRVTVNTAYGSNGVSVLRITRLTLEDSGTYECRASNDPKRNDLRQNPSITWIRAQATISVLQKPRIVTSEEVIIRDSPVLPVTLQCNLTSSSHTLTYSYWTKNGVELSATRKNASNMEYRINKPRAEDSGEYHCVYHFVSAPKANATIEVKAAPDITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATNAIGSASVVTVLRVRSHLAPLWPFLGILAEIIILVVIIVVYEKRKRPDEVPDDDEPAGPMKTNSTNNHKDKNLRQRNTN
Alternative Products
Event=Alternative splicing; Named isoforms=5; Name=2; Synonyms=SDR-1-beta; IsoId=Q9Y639-2; Sequence=Displayed; Name=1; Synonyms=SDR-1-alpha; IsoId=Q9Y639-1; Sequence=VSP_039251; Name=3; IsoId=Q9Y639-3; Sequence=VSP_039251, VSP_039253; Name=4; IsoId=Q9Y639-4; Sequence=VSP_039252; Name=5; IsoId=Q9Y639-5; Sequence=VSP_039253
Alternative Sequence
31..147; AGFVKSPMSETKLTGDAFELYCDVVGSPTPEIQWWYAEVNRAESFRQLWDGARKRRVTVNTAYGSNGVSVLRITRLTLEDSGTYECRASNDPKRNDLRQNPSITWIRAQATISVLQK -> E (in isoform 1 and isoform 3); 320..398; NAIGSASVVTVLRVRSHLAPLWPFLGILAEIIILVVIIVVYEKRKRPDEVPDDDEPAGPMKTNSTNNHKDKNLRQRNTN -> WPHSGLSWEFWLKLSSLW (in isoform 4); 372..375; Missing (in isoform 3 and isoform 5)
3D Structural Models
3D Structure
Electron microscopy (1)
Domain & Motif Annotations
Domain (CC)
Some isoforms lack the first Ig-like domain which may confer homophilic adhesion activity. However, they can bind and activate FGFR1 (By similarity).
Domain (FT)
29..134; Ig-like 1; 148..235; Ig-like 2; 238..329; Ig-like 3
Region
149..161; Narpin; mediates binding with FGFR1 and has antidepressant-like activity; 365..398; Disordered
Clinical Relevance
Interaction Protein
ENSG00000070961ENSG00000127022
Interaction Count
2
Interaction Dataset
biogrid_opencell