Protein detail

KPTN

KICSTOR complex protein kaptin (Actin-associated protein 2E4)

Entry name
KPTN
UniProt ID
Q9Y664
EVMP confidence score
0.53
Supporting publications (n)
5
Transmembrane count
Protein classification
Disease related genesHuman disease related genesPredicted intracellular proteins
Basic Information
Protein Names
KICSTOR complex protein kaptin (Actin-associated protein 2E4)
Protein Class (3)
Disease related genesHuman disease related genesPredicted intracellular proteins
Protein Function (3)
  • Disease related genes
  • Human disease related genes:Other diseases:Mental and behavioural disorders
  • Predicted intracellular proteins
Ensembl
ENSG00000118162
Entrez Gene Symbol
KPTN
Gene Synonym (2)
2E4KICS4
Gene Description
Kaptin, actin binding protein
Chromosome
19
Position
47475150-47484265
Supporting publications (n)
5
EVMP confidence score
0.53
Fluorescence & Localization
KPTN fluorescence
Function & Pathway
Protein Function (3)
  • Disease related genes
  • Human disease related genes:Other diseases:Mental and behavioural disorders
  • Predicted intracellular proteins
Cellular Component (6)
Molecular Function
GO:0051015 actin filament binding
Biological Process (3)
Reactome (3)
Mediation Categories
Fusion and delivery mediation
Relations & Evidence9

Ligand-Receptor Signaling (4)

4 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
intracellularintracellularComPPI
intracellularintracellularGO_Intercell
intracellularintracellularUniProt_location
intracellularintracellularOmniPath

Protein Complex Composition (4)

4 records.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
KICSTOR complexITFG2KICS2KPTNSZT2Q5T011Q969R8Q96MD2Q9Y6641:1:1:1CORUMhu.MAPComplexPortalintact:EBI-26361505CORUM:67542819930614755292
ITFG2KICS2KPTNSZT2TMCO4Q5T011Q5TGY1Q969R8Q96MD2Q9Y6640:0:0:0:0hu.MAPhu.MAP2
ITFG2KICS2KPTNTMCO4Q5TGY1Q969R8Q96MD2Q9Y6640:0:0:0hu.MAP
ITFG2KPTNQ969R8Q9Y6640:0hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Mass spectrometry0
Sequence, Structure & Domains

Sequences

Length
436
Mass
48,080
Sequence
MMGEAAVAAGPCPLREDSFTRFSSQSNVYGLAGGAGGRGELLAATLKGKVLGFRYQDLRQKIRPVAKELQFNYIPVDAEIVSIDTFNKSPPKRGLVVGITFIKDSGDKGSPFLNIYCDYEPGSEYNLDSIAQSCLNLELQFTPFQLCHAEVQVGDQLETVFLLSGNDPAIHLYKENEGLHQFEEQPVENLFPELTNLTSSVLWLDVHNFPGTSRRLSALGCQSGYVRVAHVDQRSREVLQMWSVLQDGPISRVIVFSLSAAKETKDRPLQDEYSVLVASMLEPAVVYRDLLNRGLEDQLLLPGSDQFDSVLCSLVTDVDLDGRPEVLVATYGQELLCYKYRGPESGLPEAQHGFHLLWQRSFSSPLLAMAHVDLTGDGLQELAVVSLKGVHILQHSLIQASELVLTRLRHQVEQRRRRLQGLEDGAGAGPAENAAS
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9Y664-1; Sequence=Displayed; Name=2; IsoId=Q9Y664-2; Sequence=VSP_053990
Alternative Sequence
1..240; Missing (in isoform 2)
Clinical Relevance
Disease Involvement (2)
Disease variantIntellectual disability
Related Diseases
Intellectual disability
Antibody (2)
HPA041710HPA041796
Interaction Protein (4)
ENSG00000103148ENSG00000111203ENSG00000174206ENSG00000198198
Interaction Count
4
Interaction Dataset
biogrid_bioplex
Supporting Publications5
PMIDTitleRelated sentences
24700864Human urinary exosomes as innate immune effectors.No related sentences available
26801919Exosomes Secreted by Apoptosis-Resistant Acute Myeloid Leukemia (AML) Blasts Harbor Regulatory Network Proteins Potentially Involved in Antagonism of Apoptosis.No related sentences available
33709510Unbiased proteomic profiling of host cell extracellular vesicle composition and dynamics upon HIV-1 infection.No related sentences available
38731868The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer.No related sentences available
41201090Identification of molecular markers and exploration of the oncogenic role of exomeres in hepatocellular carcinoma.No related sentences available