Protein detail

S12A7

Solute carrier family 12 member 7 (Electroneutral potassium-chloride cotransporter 4) (K-Cl cotransporter 4)

Protein symbol S12A7	UniProt ID Q9Y666	EVMP score 0.25
Frequency 1	Transmembrane count 12	Protein classification Metabolic proteinsPlasma proteinsPredicted membrane proteinsTransporters

Basic Information

Protein Names

Solute carrier family 12 member 7 (Electroneutral potassium-chloride cotransporter 4) (K-Cl cotransporter 4)

Protein Class

Metabolic proteinsPlasma proteinsPredicted membrane proteinsTransporters

Protein Function

Transporters:Electrochemical Potential-driven transporters

Transmembrane

120..142; Discontinuously helical; Name=1; 150..172; Helical; Name=2; 197..225; Helical; Name=3; 250..270; Helical; Name=4; 272..300; Helical; Name=5; 420..440; Helical; Name=6; 451..473; Helical; Name=7; 505..531; Helical; Name=8; 555..571; Helical; Name=9; 574..598; Helical; Name=10; 613..632; Helical; Name=11; 636..651; Helical; Name=12

Transmembrane Count

Ensembl

ENSG00000113504

Entrez Gene Symbol

SLC12A7

Gene Synonym

DKFZP434F076KCC4

Gene Description

Solute carrier family 12 member 7

Chromosome

Position

1050384-1112063

Frequency

EVMP Score

0.25

Fluorescence & Localization

Tissue SpecificintestineCell SpecificHematopoietic stem cellsSingle-Nuclei Brain SpecificleukocyteBlood Cell SpecificMAIT T-cellBlood Lineage SpecificT-cells

Function & Pathway

Protein Function

Transporters:Electrochemical Potential-driven transporters

Cellular Component

Molecular Function

Biological Process

KEGG

hsa04966 Collecting duct acid secretion

Reactome

Mediation Categories

Clinical-translation mediationFusion and delivery mediationMetabolism mediation

Relations & Evidence

Enzyme-Mediated Modification

2 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
SLC12A7	STK39	Q9UEW8	T	973	phosphorylation	PhosphoSite_ProtMapperProtMapper
SLC12A7	STK39	Q9UEW8	T	980	phosphorylation	PhosphoSite_ProtMapperProtMapper

Ligand-Receptor Signaling

27 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
plasma_membrane	plasma_membrane	OmniPath	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	CSPA	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	OmniPath	No	No	No	Yes	No
cell_surface	cell_surface	Surfaceome	No	No	No	Yes	No
cell_surface	cell_surface	OmniPath	No	No	No	Yes	No
receptor	receptor	scConnect	No	Yes	No	Yes	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	Yes	No

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Regulatory Interaction Network

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
WNK3	Q9BYP7	S12A7	Q9Y666	Yes	No	Yes	SIGNOR	SIGNOR:21613606

Protein Complex Composition

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	SLC12A7	Q9Y666	2	PDB	PDB:7d99

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	1	30550287

Sequence, Structure & Domains

Sequences

Length

1,083

Mass

119,106

Sequence

MPTNFTVVPVEAHADGGGDETAERTEAPGTPEGPEPERPSPGDGNPRENSPFLNNVEVEQESFFEGKNMALFEEEMDSNPMVSSLLNKLANYTNLSQGVVEHEEDEESRRREAKAPRMGTFIGVYLPCLQNILGVILFLRLTWIVGVAGVLESFLIVAMCCTCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEIFLTYISPGAAIFQAEAAGGEAAAMLHNMRVYGTCTLVLMALVVFVGVKYVNKLALVFLACVVLSILAIYAGVIKSAFDPPDIPVCLLGNRTLSRRSFDACVKAYGIHNNSATSALWGLFCNGSQPSAACDEYFIQNNVTEIQGIPGAASGVFLENLWSTYAHAGAFVEKKGVPSVPVAEESRASALPYVLTDIAASFTLLVGIYFPSVTGIMAGSNRSGDLKDAQKSIPTGTILAIVTTSFIYLSCIVLFGACIEGVVLRDKFGEALQGNLVIGMLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIARDGIVPFLQVFGHGKANGEPTWALLLTVLICETGILIASLDSVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKFYHWTLSFLGMSLCLALMFICSWYYALSAMLIAGCIYKYIEYRGAEKEWGDGIRGLSLNAARYALLRVEHGPPHTKNWRPQVLVMLNLDAEQAVKHPRLLSFTSQLKAGKGLTIVGSVLEGTYLDKHMEAQRAEENIRSLMSTEKTKGFCQLVVSSSLRDGMSHLIQSAGLGGLKHNTVLMAWPASWKQEDNPFSWKNFVDTVRDTTAAHQALLVAKNVDSFPQNQERFGGGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQVDDNSIQMKKDLQMFLYHLRISAEVEVVEMVENDISAFTYERTLMMEQRSQMLKQMQLSKNEQEREAQLIHDRNTASHTAAAARTQAPPTPDKVQMTWTREKLIAEKYRSRDTSLSGFKDLFSMKPDQSNVRRMHTAVKLNGVVLNKSQDAQLVLLNMPGPPKNRQGDENYMEFLEVLTEGLNRVLLVRGGGREVITIYS

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9Y666-1; Sequence=Displayed; Name=2; IsoId=Q9Y666-2; Sequence=VSP_006119, VSP_006120

Alternative Sequence

227..266; YISPGAAIFQAEAAGGEAAAMLHNMRVYGTCTLVLMALVV -> GTEDGVGSLGLGLAQGNRRQTHLSPSDAAQAAHGASYGSF (in isoform 2); 267..1083; Missing (in isoform 2)

3D Structural Models

Turn

375..379; 406..408; 439..442; 488..491; 735..737

Helix

86..89; 100..103; 120..123; 125..130; 136..139; 141..163; 165..176; 186..190; 194..227; 240..242; 243..268; 270..275; 277..300; 337..342; 354..358; 420..427; 428..430; 434..438; 447..474; 479..482; 485..487; 495..499; 505..524; 526..536; 544..546; 556..569; 574..601; 616..633; 635..658; 664..680; 710..718; 741..755; 770..780; 804..820; 831..833; 855..865; 888..895; 897..901; 1012..1030; 1051..1061

Beta Strand

306..310; 325..329; 332..335; 343..347; 361..366; 370..372; 393..395; 443..445; 500..502; 538..540; 661..663; 694..698; 725..733; 761..769; 790..794; 824..830; 845..849; 868..873; 875..881; 906..911; 1035..1040; 1046..1048; 1068..1072

3D Structure

Electron microscopy (1)

Domain & Motif Annotations

Compositional Bias

12..26; Basic and acidic residues

Region

1..52; Disordered; 664..680; Scissor helix

Protein Families

SLC12A transporter family
K/Cl co-transporter subfamily

Sequence Similarities

Belongs to the SLC12A transporter family. K/Cl co-transporter subfamily.

Clinical Relevance

Drug Targets

Literature-reported target

Antibody

HPA041652

Interaction Protein

ENSG00000131981

Interaction Count

Interaction Dataset

biogrid_bioplex