Protein detail

CLIC4

Chloride intracellular channel protein 4 (Glutaredoxin-like oxidoreductase CLIC4) (EC 1.8.-.-) (Intracellular chloride ion channel protein p64H1)

Entry name
CLIC4
UniProt ID
Q9Y696
EVMP confidence score
0.88
Supporting publications (n)
41
Transmembrane count
1
Protein classification
Predicted intracellular proteinsTransporters
EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information13
Protein Names
Chloride intracellular channel protein 4 (Glutaredoxin-like oxidoreductase CLIC4) (EC 1.8.-.-) (Intracellular chloride ion channel protein p64H1)
Protein Class (2)
Predicted intracellular proteinsTransporters
Protein Function (2)
  • Transporters:Transporter channels and pores
  • Predicted intracellular proteins
Transmembrane
37..57; Helical; Note=After insertion into the membrane
Transmembrane Count
1
Ensembl
ENSG00000169504
Entrez Gene Symbol
CLIC4
Gene Synonym (5)
CLIC4LDKFZP566G223H1huH1P64H1
Gene Description
Chloride intracellular channel 4
Chromosome
1
Position
24745382-24844321
Supporting publications (n)
41
EVMP confidence score
0.88
Fluorescence & Localization4
CLIC4 fluorescence
Cell SpecificAdrenal medulla cellsBlood Cell SpecificeosinophilBlood Lineage Specificgranulocytes
Function & Pathway6
Protein Function (2)
  • Transporters:Transporter channels and pores
  • Predicted intracellular proteins
Cellular Component (19)
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Molecular Function (3)
Biological Process (3)
Canonical Pathways (3)
  • M5883 Naba secreted factors
  • M5885 Naba matrisome associated
  • M5889 Naba matrisome
Mediation Categories (2)
Clinical-translation mediationFusion and delivery mediation
Relations & Evidence21

Ligand-Receptor Signaling (11)

11 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
plasma_membraneplasma_membraneOmniPathNoNoNoNoNo
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Regulatory Interaction Network (1)

1 record.

Source Protein SymbolSource UniProt IDTarget Protein SymbolTarget UniProt IDIs DirectedIs StimulationIs InhibitionDatabaseReferences
CDK5Q00535CLIC4Q9Y696YesYesNoSIGNORSparser_ProtMapperProtMapperSIGNOR:30237421ProtMapper:30237421

Protein Complex Composition (8)

Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyImmunoaffinity CaptureMass spectrometry6381133683732247541068253335925004130796838607062
Sequence, Structure & Domains13

Sequences

Length
253
Mass
28,772
Sequence
MALSMPLNGLKEEDKEPLIELFVKAGSDGESIGNCPFSQRLFMILWLKGVVFSVTTVDLKRKPADLQNLAPGTHPPFITFNSEVKTDVNKIEEFLEEVLCPPKYLKLSPKHPESNTAGMDIFAKFSAYIKNSRPEANEALERGLLKTLQKLDEYLNSPLPDEIDENSMEDIKFSTRKFLDGNEMTLADCNLLPKLHIVKVVAKKYRNFDIPKEMTGIWRYLTNAYSRDEFTNTCPSDKEVEIAYSDVAKRLTK

3D Structural Models

Turn
101..103; 116..120; 244..247
Helix
36..48; 64..69; 88..98; 112..115; 121..130; 134..136; 137..156; 186..206; 215..225; 228..231; 237..243
Beta Strand
19..25; 29..32; 53..57; 77..80; 83..85; 181..183
3D Structure
X-ray crystallography (3)

Domain & Motif Annotations

Motif
35..38; G-site
Domain (CC)
The active G-site contains a monothiol Cys-X-X-Ser motif which mediates glutathione-dependent redox catalysis.; DOMAIN: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as a chloride channel. The redox status of the active cysteine in Cys-X-X-Cys/Ser motif likely determines the capacity to adopt a soluble or membrane-inserted state. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
Domain (FT)
81..244; GST C-terminal
Region
2..101; Required for insertion into the membrane
Protein Families
Chloride channel CLIC family
Sequence Similarities
Belongs to the chloride channel CLIC family.
Clinical Relevance5
Drug Targets
Literature-reported target
Antibody (2)
HPA008019HPA060804
Interaction Protein
ENSG00000159212
Interaction Count
1
Interaction Dataset
intact_biogrid
Supporting Publications41
PMIDTitleAbstract
39022990Placenta-derived mesenchymal stem cells promote diabetic wound healing via exosomal protein interaction networks.No abstract available
39290459Urinary extracellular vesicles as a monitoring tool for renal damage in patients not meeting criteria for chronic kidney disease.No abstract available
39443544Profiling of urinary extracellular vesicle protein signatures from patients with cribriform and intraductal prostate carcinoma in a cross-sectional study.No abstract available
39873726Size-Dependent Separation of Extracellular Vesicle Subtypes with Exodisc Enabling Proteomic Analysis in Prostate Cancer.No abstract available
39949490CRISPR-dCas9 Activation of TSG-6 in MSCs Modulates the Cargo of MSC-Derived Extracellular Vesicles and Attenuates Inflammatory Responses in Human Intervertebral Disc Cells In Vitro.No abstract available
40091455Potential Role of Menstrual Fluid-Derived Small Extracellular Vesicle Proteins in Endometriosis Pathogenesiss.No abstract available
40311616Integrative proteomic profiling of tumor and plasma extracellular vesicles identifies a diagnostic biomarker panel for colorectal cancer.No abstract available
40545963Extracellular Vesicle Proteome Analysis Improves Diagnosis of Recurrence in Triple-Negative Breast Cancer.No abstract available
40784529Serum-derived exosome proteomics unveils the distinct and adjustable nature of the dampness constitution in traditional Chinese medicine.No abstract available
41216884Extracellular Vesicles From Multiple Sclerosis White Matter Exhibit Synaptic, Mitochondrial, Complement and Ageing-Related Pathway Dysregulation.No abstract available
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