Protein detail

ATP23

Mitochondrial inner membrane protease ATP23 homolog (EC 3.4.24.-) (Ku70-binding protein 3) (XRCC6-binding protein 1)

Entry name ATP23	UniProt ID Q9Y6H3	EVMP score 0.38
Frequency 4	Transmembrane count	Protein classification EnzymesEssential proteinsPredicted intracellular proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Mitochondrial inner membrane protease ATP23 homolog (EC 3.4.24.-) (Ku70-binding protein 3) (XRCC6-binding protein 1)

Protein Class

EnzymesEssential proteinsPredicted intracellular proteins

Protein Function

Peptidases:Metallopeptidases
Enzymes
Predicted intracellular proteins

Ensembl

ENSG00000166896

Entrez Gene Symbol

ATP23

Gene Synonym

KUB3XRCC6BP1

Gene Description

ATP23 metallopeptidase and ATP synthase assembly factor homolog

Chromosome

Position

57906039-57959148

Frequency

EVMP Score

0.38

Fluorescence & Localization

Tissue SpecificlungCell SpecificB-cellsSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell Specificmyeloid DCBlood Lineage SpecificB-cells

Function & Pathway

Protein Function

Peptidases:Metallopeptidases
Enzymes
Predicted intracellular proteins

Cellular Component

Molecular Function

Biological Process

Mediation Categories

Metabolism mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

3 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Regulatory Interaction Network

0 records.

Protein Complex Composition

4 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
DNA-dependent protein kinase-DNA ligase 4 complex	ATP23 LIG4 PRKDC XRCC4 XRCC5 XRCC6	P12956 P13010 P49917 P78527 Q13426 Q9Y6H3	1:1:1:1:1:1	Compleat	Compleat:HC1767	15194694 10219089
	ATP23 BACH1 MAFB MAFG MAFK NFE2L3	O14867 O15525 O60675 Q9Y4A8 Q9Y5Q3 Q9Y6H3	0:0:0:0:0:0	hu.MAP2
	ATP23 BACH1 FAM83D HMMR MAFB MAFK	O14867 O60675 O75330 Q9H4H8 Q9Y5Q3 Q9Y6H3	0:0:0:0:0:0	hu.MAP2
	ATP23 CSPP1 GAN KBTBD8 KLHL29 MOG WDR76	Q16653 Q1MSJ5 Q8NFY9 Q96CT2 Q9H2C0 Q9H967 Q9Y6H3	0:0:0:0:0:0:0	hu.MAP2

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
	Mass spectrometry	0

Sequence, Structure & Domains

Sequences

Length

246

Mass

28,081

Sequence

MAGAPDERRRGPAAGEQLQQQHVSCQVFPERLAQGNPQQGFFSSFFTSNQKCQLRLLKTLETNPYVKLLLDAMKHSGCAVNKDRHFSCEDCNGNVSGGFDASTSQIVLCQNNIHNQAHMNRVVTHELIHAFDHCRAHVDWFTNIRHLACSEVRAANLSGDCSLVNEIFRLHFGLKQHHQTCVRDRATLSILAVRNISKEVAKKAVDEVFESCFNDHEPFGRIPHNKTYARYAHRDFENRDRYYSNI

3D Structural Models

Domain & Motif Annotations

Protein Families

Peptidase M76 family

Sequence Similarities

Belongs to the peptidase M76 family.

Clinical Relevance

Antibody

HPA035804 HPA043204