Protein detail

ZNT1

Proton-coupled zinc antiporter SLC30A1 (Solute carrier family 30 member 1) (Zinc transporter 1)

Entry name ZNT1	UniProt ID Q9Y6M5	EVMP confidence score 0.50
Supporting publications (n) 2	Transmembrane count 6	Protein classification Metabolic proteinsPredicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Proton-coupled zinc antiporter SLC30A1 (Solute carrier family 30 member 1) (Zinc transporter 1)

Protein Class (3)

Metabolic proteinsPredicted membrane proteinsTransporters

Protein Function

Transporters:Electrochemical Potential-driven transporters

Transmembrane

11..31; Helical; 36..56; Helical; 79..99; Helical; 114..134; Helical; 249..269; Helical; 309..329; Helical

Transmembrane Count

Ensembl

ENSG00000170385

Entrez Gene Symbol

SLC30A1

Gene Synonym (2)

ZNT1ZRC1

Gene Description

Solute carrier family 30 member 1

Chromosome

Position

211571568-211579161

Supporting publications (n)

EVMP confidence score

0.50

Function & Pathway7

Protein Function

Transporters:Electrochemical Potential-driven transporters

Cellular Component (16)

Page 1 of 2

Molecular Function (5)

Biological Process (3)

KEGG

hsa04978 Mineral absorption

Reactome (5)

Mediation Categories (2)

Fusion and delivery mediationMetabolism mediation

Relations & Evidence34

Ligand-Receptor Signaling (23)

23 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane	transmembrane	UniProt_location	No	No	No	No	No
transmembrane	transmembrane	UniProt_topology	No	No	No	No	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	No	No
transmembrane	transmembrane	TopDB	No	No	No	No	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	No	No
transmembrane	transmembrane	OmniPath	No	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
basolateral_cell_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No
cell_surface	cell_surface	Surfaceome	No	No	No	No	No

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Protein Complex Composition (10)

10 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
ZNT1 proton-coupled zinc antiporter homodimer	SLC30A1	Q9Y6M5	2	ComplexPortalPDB	PDB:8zsbPDB:8xmfintact:EBI-47263219PDB:8xm6PDB:8zb0PDB:8j2gPDB:8xmaPDB:8xmjPDB:8zsz	33485965 31471319 14755292
ZNT1-ZNT2 proton-coupled zinc antiporter complex	SLC30A1 SLC30A2	Q9BRI3 Q9Y6M5	1:1	ComplexPortal	intact:EBI-48415582	33485965 14755292 26728129
ZNT1-ZNT3 proton-coupled zinc antiporter complex	SLC30A1 SLC30A3	Q99726 Q9Y6M5	1:1	ComplexPortal	intact:EBI-48416083	33485965 14755292 21548772 19521526
ZNT1-ZNT4 proton-coupled zinc antiporter complex	SLC30A1 SLC30A4	O14863 Q9Y6M5	1:1	ComplexPortal	intact:EBI-48417575	33485965 31471319 14755292 25657003
ZNT10 calcium-coupled manganese antiporter homodimer	SLC30A10	Q6XR72	2	ComplexPortal	intact:EBI-48418416	14755292 30755481 26728129
ZNT2-ZNT10 proton-coupled zinc antiporter complex	SLC30A10 SLC30A2	Q6XR72 Q9BRI3	1:1	ComplexPortal	intact:EBI-48418444	25808614 33485965 14755292 26728129
ZNT3-ZNT10 proton-coupled zinc antiporter complex	SLC30A10 SLC30A3	Q6XR72 Q99726	1:1	ComplexPortal	intact:EBI-48418473	25808614 33485965 14755292 26728129
ZNT4-ZNT10 proton-coupled zinc antiporter complex	SLC30A10 SLC30A4	O14863 Q6XR72	1:1	ComplexPortal	intact:EBI-48418502	25808614 33485965 14755292 26728129
	CHEK1 CHRNA9 NAT9 SLC30A1 SLC30A7 TIMM29 TP53I13	O14757 Q8NBR0 Q8NEW0 Q9BSF4 Q9BTE0 Q9UGM1 Q9Y6M5	0:0:0:0:0:0:0	hu.MAP2
	CSGALNACT1 SLC30A1	Q8TDX6 Q9Y6M5	0:0	hu.MAPhu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometry	8	38113368 37322475 38895962 41068253 33592500 41307968 32230970 34576246

Sequence, Structure & Domains11

Sequences

Length

507

Mass

55,300

Sequence

MGCWGRNRGRLLCMLALTFMFMVLEVVVSRVTSSLAMLSDSFHMLSDVLALVVALVAERFARRTHATQKNTFGWIRAEVMGALVNAIFLTGLCFAILLEAIERFIEPHEMQQPLVVLGVGVAGLLVNVLGLCLFHHHSGFSQDSGHGHSHGGHGHGHGLPKGPRVKSTRPGSSDINVAPGEQGPDQEETNTLVANTSNSNGLKLDPADPENPRSGDTVEVQVNGNLVREPDHMELEEDRAGQLNMRGVFLHVLGDALGSVIVVVNALVFYFSWKGCSEGDFCVNPCFPDPCKAFVEIINSTHASVYEAGPCWVLYLDPTLCVVMVCILLYTTYPLLKESALILLQTVPKQIDIRNLIKELRNVEGVEEVHELHVWQLAGSRIIATAHIKCEDPTSYMEVAKTIKDVFHNHGIHATTIQPEFASVGSKSSVVPCELACRTQCALKQCCGTLPQAPSGKDAEKTPAVSISCLELSNNLEKKPRRTKAENIPAVVIEIKNMPNKQPESSL

3D Structural Models

Turn

293..296

Helix

7..32; 35..41; 42..44; 45..60; 77..105; 113..134; 241..271; 290..292; 310..313; 316..343; 353..361; 393..395; 396..409

Beta Strand

278..281; 285..288; 363..365; 368..378; 381..389; 414..420

3D Structure

Electron microscopy (8)

Domain & Motif Annotations

Compositional Bias

147..167; Basic residues; 189..201; Polar residues

Region

142..217; Disordered; 146..158; 6 X 2 AA approximate repeats of H-G

Protein Families (2)

Cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SLC30A subfamily

Sequence Similarities

Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.

Clinical Relevance4

Antibody (2)

HPA015275 HPA049000

Interaction Protein

ENSG00000168961

Interaction Count

Interaction Dataset

biogrid_bioplex

Supporting Publications2

PMID	Title	Abstract
37922300	Proteomic profiling of urinary extracellular vesicles differentiates breast cancer patients from healthy women.	No abstract available
38731868	The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer.	No abstract available