Protein detail

DGKB

Diacylglycerol kinase beta (DAG kinase beta) (EC 2.7.1.107) (90 kDa diacylglycerol kinase) (Diglyceride kinase beta) (DGK-beta)

Entry name
DGKB
UniProt ID
Q9Y6T7
EVMP confidence score
0.53
Supporting publications (n)
1
Transmembrane count
Protein classification
Basic Information
Protein Names
Diacylglycerol kinase beta (DAG kinase beta) (EC 2.7.1.107) (90 kDa diacylglycerol kinase) (Diglyceride kinase beta) (DGK-beta)
Protein Function (3)
  • ENZYME proteins:Transferases
  • Enzymes
  • Predicted intracellular proteins
Ensembl
ENSG00000136267
Entrez Gene Symbol
DGKB
Supporting publications (n)
1
EVMP confidence score
0.53
Fluorescence & Localization
DGKB fluorescence
Tissue SpecificplacentaCell SpecificAdipocytesSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell SpecificNK-cellSecretome LocationSecreted - unknown locationSecretome FunctionEnzyme
Function & Pathway
Protein Function (3)
  • ENZYME proteins:Transferases
  • Enzymes
  • Predicted intracellular proteins
Cellular Component (4)
Molecular Function (4)
Biological Process (3)
KEGG (6)
Reactome (5)
Mediation Categories (3)
Immune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence7

Ligand-Receptor Signaling (6)

6 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
intracellularintracellularComPPI
intracellularintracellularGO_Intercell
intracellularintracellularUniProt_location
intracellularintracellularOmniPath
plasma_membraneplasma_membraneUniProt_location
plasma_membraneplasma_membraneOmniPath

Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Polymer PrecipitationWestern blotting138731868
Sequence, Structure & Domains

Sequences

Length
804
Mass
90,595
Sequence
MTNQEKWAHLSPSEFSQLQKYAEYSTKKLKDVLEEFHGNGVLAKYNPEGKQDILNQTIDFEGFKLFMKTFLEAELPDDFTAHLFMSFSNKFPHSSPMVKSKPALLSGGLRMNKGAITPPRTTSPANTCSPEVIHLKDIVCYLSLLERGRPEDKLEFMFRLYDTDGNGFLDSSELENIISQMMHVAEYLEWDVTELNPILHEMMEEIDYDHDGTVSLEEWIQGGMTTIPLLVLLGLENNVKDDGQHVWRLKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVARAPPSCIKTYVKSKRNTDVMHHYWVEGNCPTKCDKCHKTVKCYQGLTGLHCVWCQITLHNKCASHLKPECDCGPLKDHILPPTTICPVVLQTLPTSGVSVPEERQSTVKKEKSGSQQPNKVIDKNKMQRANSVTVDGQGLQVTPVPGTHPLLVFVNPKSGGKQGERIYRKFQYLLNPRQVYSLSGNGPMPGLNFFRDVPDFRVLACGGDGTVGWVLDCIEKANVGKHPPVAILPLGTGNDLARCLRWGGGYEGENLMKILKDIENSTEIMLDRWKFEVIPNDKDEKGDPVPYSIINNYFSIGVDASIAHRFHIMREKHPEKFNSRMKNKFWYFEFGTSETFSATCKKLHESVEIECDGVQIDLINISLEGIAILNIPSMHGGSNLWGESKKRRSHRRIEKKGSDKRTTVTDAKELKFASQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCSCVVIRTSKSLPMQIDGEPWMQTPCTIKITHKNQAPMLMGPPPKTGLFCSLVKRTRNRSKE
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=STD; IsoId=Q9Y6T7-1; Sequence=Displayed; Name=2; Synonyms=SV3'; IsoId=Q9Y6T7-2; Sequence=VSP_021898, VSP_021899
Alternative Sequence
770..773; IKIT -> VSTE (in isoform 2); 774..804; Missing (in isoform 2)

Domain & Motif Annotations

Compositional Bias
389..401; Basic and acidic residues; 678..687; Basic residues
Zinc Finger
244..294; Phorbol-ester/DAG-type 1; 309..358; Phorbol-ester/DAG-type 2
Domain (FT)
149..184; EF-hand 1; 194..229; EF-hand 2; 434..568; DAGKc
Region
385..406; Disordered; 673..694; Disordered; 771..804; Required for association with membranes and function in neurite spine formation
Protein Families
Eukaryotic diacylglycerol kinase family
Sequence Similarities
Belongs to the eukaryotic diacylglycerol kinase family.
Clinical Relevance
Drugs
NULL
Supporting Publications1
PMIDTitleRelated sentences
37427430Multiomics of Tissue Extracellular Vesicles Identifies Unique Modulators of Atherosclerosis and Calcific Aortic Valve Stenosis.No related sentences available