Protein detail

DGKB

Diacylglycerol kinase beta (DAG kinase beta) (EC 2.7.1.107) (90 kDa diacylglycerol kinase) (Diglyceride kinase beta) (DGK-beta)

Entry name DGKB	UniProt ID Q9Y6T7	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count	Protein classification

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information6

Protein Names

Diacylglycerol kinase beta (DAG kinase beta) (EC 2.7.1.107) (90 kDa diacylglycerol kinase) (Diglyceride kinase beta) (DGK-beta)

Protein Function (3)

ENZYME proteins:Transferases
Enzymes
Predicted intracellular proteins

Ensembl

ENSG00000136267

Entrez Gene Symbol

DGKB

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization7

Tissue SpecificplacentaCell SpecificAdipocytesSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell SpecificNK-cellSecretome LocationSecreted - unknown locationSecretome FunctionEnzyme

Function & Pathway7

Protein Function (3)

ENZYME proteins:Transferases
Enzymes
Predicted intracellular proteins

Cellular Component (4)

Molecular Function (4)

Biological Process (3)

KEGG (6)

Reactome (5)

Mediation Categories (3)

Immune mediationMetabolism mediationReceptor-signaling mediation

Relations & Evidence7

Ligand-Receptor Signaling (6)

6 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Polymer Precipitation	Western blotting	1	38731868

Sequence, Structure & Domains11

Sequences

Length

804

Mass

90,595

Sequence

MTNQEKWAHLSPSEFSQLQKYAEYSTKKLKDVLEEFHGNGVLAKYNPEGKQDILNQTIDFEGFKLFMKTFLEAELPDDFTAHLFMSFSNKFPHSSPMVKSKPALLSGGLRMNKGAITPPRTTSPANTCSPEVIHLKDIVCYLSLLERGRPEDKLEFMFRLYDTDGNGFLDSSELENIISQMMHVAEYLEWDVTELNPILHEMMEEIDYDHDGTVSLEEWIQGGMTTIPLLVLLGLENNVKDDGQHVWRLKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVARAPPSCIKTYVKSKRNTDVMHHYWVEGNCPTKCDKCHKTVKCYQGLTGLHCVWCQITLHNKCASHLKPECDCGPLKDHILPPTTICPVVLQTLPTSGVSVPEERQSTVKKEKSGSQQPNKVIDKNKMQRANSVTVDGQGLQVTPVPGTHPLLVFVNPKSGGKQGERIYRKFQYLLNPRQVYSLSGNGPMPGLNFFRDVPDFRVLACGGDGTVGWVLDCIEKANVGKHPPVAILPLGTGNDLARCLRWGGGYEGENLMKILKDIENSTEIMLDRWKFEVIPNDKDEKGDPVPYSIINNYFSIGVDASIAHRFHIMREKHPEKFNSRMKNKFWYFEFGTSETFSATCKKLHESVEIECDGVQIDLINISLEGIAILNIPSMHGGSNLWGESKKRRSHRRIEKKGSDKRTTVTDAKELKFASQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCSCVVIRTSKSLPMQIDGEPWMQTPCTIKITHKNQAPMLMGPPPKTGLFCSLVKRTRNRSKE

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=STD; IsoId=Q9Y6T7-1; Sequence=Displayed; Name=2; Synonyms=SV3'; IsoId=Q9Y6T7-2; Sequence=VSP_021898, VSP_021899

Alternative Sequence

770..773; IKIT -> VSTE (in isoform 2); 774..804; Missing (in isoform 2)

Domain & Motif Annotations

Compositional Bias

389..401; Basic and acidic residues; 678..687; Basic residues

Zinc Finger

244..294; Phorbol-ester/DAG-type 1; 309..358; Phorbol-ester/DAG-type 2

Domain (FT)

149..184; EF-hand 1; 194..229; EF-hand 2; 434..568; DAGKc

Region

385..406; Disordered; 673..694; Disordered; 771..804; Required for association with membranes and function in neurite spine formation

Protein Families

Eukaryotic diacylglycerol kinase family

Sequence Similarities

Belongs to the eukaryotic diacylglycerol kinase family.

Clinical Relevance1

Drugs

NULL

Supporting Publications1

PMID	Title	Abstract
37427430	Multiomics of Tissue Extracellular Vesicles Identifies Unique Modulators of Atherosclerosis and Calcific Aortic Valve Stenosis.	No abstract available