Protein detail
SCIN
Scinderin (Adseverin)
Entry name SCIN | UniProt ID | EVMP confidence score 0.40 |
Supporting publications (n) 1 | Transmembrane count | Protein classification Plasma proteinsPredicted intracellular proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Scinderin (Adseverin)
Protein Class (2)
Plasma proteinsPredicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
KIAA1905
Gene Description
Scinderin
Chromosome
7
Position
12570577-12660182
Supporting publications (n)
1
EVMP confidence score
0.40
Fluorescence & Localization
Tissue SpecificbrainCell SpecificBergmann gliaBlood Cell Specificintermediate monocyteBlood Lineage Specificmonocytes
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component (8)
Molecular Function (6)
Biological Process (3)
KEGG (3)
Mediation Categories (2)
Fusion and delivery mediationImmune mediation
Relations & Evidence10
Ligand-Receptor Signaling (5)
5 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | |||||
| intracellular | intracellular | ComPPI | |||||
| intracellular | intracellular | GO_Intercell | |||||
| intracellular | intracellular | UniProt_location | |||||
| intracellular | intracellular | OmniPath |
Protein Complex Composition (4)
4 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| AGTPBP1FLIILRRFIP1SCINTCEAL2TMOD1 | P28289Q13045Q32MZ4Q9H3H9Q9UPW5Q9Y6U3 | 0:0:0:0:0:0 | hu.MAP2 | |||
| FLIILRRFIP1SCINTMOD1 | P28289Q13045Q32MZ4Q9Y6U3 | 0:0:0:0 | hu.MAP | |||
| SCINTMOD2 | Q9NZR1Q9Y6U3 | 0:0 | hu.MAP | |||
| SCIN | Q9Y6U3 | 8 | PDB | PDB:3fg6PDB:5a1k |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Western blotting | 1 | 30143647 |
Sequence, Structure & Domains
Sequences
Length
715
Mass
80,489
Sequence
MARELYHEEFARAGKQAGLQVWRIEKLELVPVPQSAHGDFYVGDAYLVLHTAKTSRGFTYHLHFWLGKECSQDESTAAAIFTVQMDDYLGGKPVQNRELQGYESNDFVSYFKGGLKYKAGGVASGLNHVLTNDLTAKRLLHVKGRRVVRATEVPLSWDSFNKGDCFIIDLGTEIYQWCGSSCNKYERLKANQVATGIRYNERKGRSELIVVEEGSEPSELIKVLGEKPELPDGGDDDDIIADISNRKMAKLYMVSDASGSMRVTVVAEENPFSMAMLLSEECFILDHGAAKQIFVWKGKDANPQERKAAMKTAEEFLQQMNYSKNTQIQVLPEGGETPIFKQFFKDWRDKDQSDGFGKVYVTEKVAQIKQIPFDASKLHSSPQMAAQHNMVDDGSGKVEIWRVENNGRIQVDQNSYGEFYGGDCYIILYTYPRGQIIYTWQGANATRDELTTSAFLTVQLDRSLGGQAVQIRVSQGKEPVHLLSLFKDKPLIIYKNGTSKKGGQAPAPPTRLFQVRRNLASITRIVEVDVDANSLNSNDVFVLKLPQNSGYIWVGKGASQEEEKGAEYVASVLKCKTLRIQEGEEPEEFWNSLGGKKDYQTSPLLETQAEDHPPRLYGCSNKTGRFVIEEIPGEFTQDDLAEDDVMLLDAWEQIFIWIGKDANEVEKKESLKSAKMYLETDPSGRDKRTPIVIIKQGHEPPTFTGWFLGWDSSKW
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9Y6U3-1; Sequence=Displayed; Name=2; IsoId=Q9Y6U3-2; Sequence=VSP_012427, VSP_012428; Name=3; IsoId=Q9Y6U3-3; Sequence=VSP_040548
Alternative Sequence
1..247; Missing (in isoform 3); 528..580; VDVDANSLNSNDVFVLKLPQNSGYIWVGKGASQEEEKGAEYVASVLKCKTLRI -> RSSGIPLEGKKTTRPHHYWKPRLKTIHLGFTAALTKLEDLLLKRFQESSPRMI (in isoform 2); 581..715; Missing (in isoform 2)
3D Structural Models
Turn
12..14; 89..91; 100..102; 122..125; 603..605
Helix
8..11; 34..36; 72..88; 105..108; 184..202; 218..223; 274..276; 288..290; 303..319; 338..341; 413..415; 447..463; 480..483; 532..534; 560..572; 587..592; 637..639; 664..674; 701..704
Beta Strand
15..24; 29..31; 39..41; 45..53; 58..66; 93..99; 115..119; 138..143; 145..147; 149..153; 164..169; 171..178; 206..212; 250..255; 262..272; 281..287; 292..297; 327..332; 344..346; 397..403; 405..410; 424..430; 435..441; 469..474; 491..493; 511..516; 519..521; 524..528; 539..544; 548..554; 576..581; 615..620; 627..630; 644..649; 654..658; 680..683; 691..695; 707..709
3D Structure
X-ray crystallography (3)
Domain & Motif Annotations
Repeat
27..76; Gelsolin-like 1; 148..188; Gelsolin-like 2; 265..307; Gelsolin-like 3; 398..451; Gelsolin-like 4; 523..564; Gelsolin-like 5; 626..668; Gelsolin-like 6
Region
1..363; Actin-severing; 364..715; Ca(2+)-dependent actin binding
Protein Families
Villin/gelsolin family
Sequence Similarities
Belongs to the villin/gelsolin family.
Clinical Relevance
Supporting Publications1
| PMID | Title | Related sentences |
|---|---|---|
| 38673823 | Altered Glycolysis, Mitochondrial Biogenesis, Autophagy and Apoptosis in Peritoneal Endometriosis in Adolescents. | Samples of plasma and peritoneal fluid exosomes, endometrioid foci and non-affected peritoneum were tested for estrogen receptor (Erα/β), hexokinase (Hex2), pyruvate dehydrogenase kinase (PDK1), glucose transporter (Glut1), monocarboxylate transporters (MCT1 and MCT2), optic atrophy 1 (OPA1, mitochondrial fusion protein), dynamin-related protein 1 (DRP1, mitochondrial fission protein), Bax, Bcl2, Beclin1, Bnip3, P38 mitogen-activated protein kinase (MAPK), hypoxia-inducible factor 1 (Hif-1α), mitochondrial voltage-dependent anion channel (VDAC) and transforming growth factor (TGFβ) proteins as markers of estrogen signaling, glycolysis rates, mitochondrial biogenesis and damage, apoptosis and autophagy (Western-Blot and PCR). |