Protein detail
CLM7
CMRF35-like molecule 7 (CLM-7) (CD300 antigen-like family member B) (CMRF35-A2) (Immune receptor expressed on myeloid cells 3) (IREM-3) (Leukocyte mono-Ig-like receptor 5) (Triggering receptor expressed on myeloid cells 5) (TREM-5) (CD antigen CD300b)
Protein symbol CLM7 | UniProt ID | EVMP score 0.50 |
Frequency 2 | Transmembrane count 1 | Protein classification |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
CMRF35-like molecule 7 (CLM-7) (CD300 antigen-like family member B) (CMRF35-A2) (Immune receptor expressed on myeloid cells 3) (IREM-3) (Leukocyte mono-Ig-like receptor 5) (Triggering receptor expressed on myeloid cells 5) (TREM-5) (CD antigen CD300b)
Protein Function
- CD markers
- Predicted intracellular proteins
Transmembrane
152..172; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Frequency
2
EVMP Score
0.50
Fluorescence & Localization
Cell SpecificEsophageal apical cells
Function & Pathway
Protein Function
- CD markers
- Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Reactome
Mediation Categories
Immune mediation
Relations & Evidence
Enzyme-Mediated Modification
1 record.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| CD300LB | FYN | P06241 | Y | 188 | phosphorylation | SIGNORProtMapperdbPTMPhosphoSitePhosphoSite_ProtMapper | dbPTM:16920917dbPTM:17928527SIGNOR:16920917 |
Ligand-Receptor Signaling
27 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | UniProt_location | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | Yes | No |
| transmembrane | transmembrane | GO_Intercell | No | No | No | Yes | No |
| transmembrane | transmembrane | TopDB | No | No | No | Yes | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | Yes | No |
| transmembrane | transmembrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | Cellinker | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | Yes | No |
Regulatory Interaction Network
3 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| CLM7 | A8K4G0 | TYOBP | O43914 | Yes | Yes | No | InnateDBSIGNOR | InnateDB:16920917SIGNOR:20959446 |
| CLM7 | A8K4G0 | GRB2 | P62993 | Yes | Yes | No | InnateDBSIGNOR | InnateDB:16920917SIGNOR:20959446 |
| FYN | P06241 | CLM7 | A8K4G0 | Yes | Yes | No | PhosphoSite_MIMPMIMPiPTMnetSIGNORProtMapperdbPTMInnateDBSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | dbPTM:17928527PhosphoSite:17928527PhosphoSite:16920917SIGNOR:16920917InnateDB:16920917dbPTM:16920917ProtMapper:16920917 |
Protein Complex Composition
0 records.
Sequence, Structure & Domains
Sequences
Length
201
Mass
22,689
Sequence
MWLPPALLLLSLSGCFSIQGPESVRAPEQGSLTVQCHYKQGWETYIKWWCRGVRWDTCKILIETRGSEQGEKSDRVSIKDNQKDRTFTVTMEGLRRDDADVYWCGIERRGPDLGTQVKVIVDPEGAASTTASSPTNSNMAVFIGSHKRNHYMLLVFVKVPILLILVTAILWLKGSQRVPEEPGEQPIYMNFSEPLTKDMAT
3D Structural Models
Domain & Motif Annotations
Domain (FT)
18..120; Ig-like V-type
Protein Families
CD300 family
Sequence Similarities
Belongs to the CD300 family.