Protein detail
APBB1
Amyloid beta precursor protein binding family B member 1 (Amyloid-beta A4 precursor protein-binding family B member 1) (Protein Fe65)
Entry name APBB1 | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) 1 | Transmembrane count | Protein classification Plasma proteinsPredicted intracellular proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Amyloid beta precursor protein binding family B member 1 (Amyloid-beta A4 precursor protein-binding family B member 1) (Protein Fe65)
Protein Class (2)
Plasma proteinsPredicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
Fe65RIR
Gene Description
Amyloid beta precursor protein binding family B member 1
Chromosome
11
Position
6395125-6419414
Supporting publications (n)
1
EVMP confidence score
0.38
Fluorescence & Localization4
Cell SpecificPancreatic duct cellsSecretome LocationIntracellular and membraneSecretome FunctionOther
Function & Pathway7
Protein Function
Predicted intracellular proteins
Cellular Component (9)
Molecular Function (9)
- GO:0001540 amyloid-beta binding
- GO:0003682 chromatin binding
- GO:0003713 transcription coactivator activity
- GO:0005515 protein binding
- GO:0031625 ubiquitin protein ligase binding
- GO:0042393 histone binding
- GO:0050750 low-density lipoprotein particle receptor binding
- GO:0060090 molecular adaptor activity
- GO:0070064 proline-rich region binding
Biological Process (3)
Reactome (3)
Mediation Categories
Fusion and delivery mediation
Relations & Evidence44
Enzyme-Mediated Modification (20)
20 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| APBB1 | MAPK1 | P28482 | S | 175 | phosphorylation | PhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPSIGNORProtMapperKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | KEA:14697653ProtMapper:14697653phosphoELM:14697653SIGNOR:14697653 |
| APBB1 | MAPK1 | P28482 | S | 287 | phosphorylation | PhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPSIGNORProtMapperKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | KEA:14697653ProtMapper:14697653phosphoELM:14697653SIGNOR:14697653 |
| APBB1 | MAPK1 | P28482 | T | 709 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPProtMapperKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | KEA:14697653ProtMapper:14697653phosphoELM:14697653 |
| APBB1 | MAPK1 | P28482 | S | 347 | phosphorylation | PhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPSIGNORProtMapperKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | KEA:14697653ProtMapper:14697653phosphoELM:14697653SIGNOR:14697653 |
| APBB1 | ABL1 | P00519 | Y | 547 | phosphorylation | Sparser_ProtMapperSIGNORProtMapperdbPTMKEASIGNOR_ProtMapperREACH_ProtMapper | ProtMapper:20110615ProtMapper:22506131SIGNOR:15031292dbPTM:15031292ProtMapper:26255939KEA:15031292dbPTM:18922798ProtMapper:15031292 |
| APBB1 | MAPK3 | P27361 | S | 287 | phosphorylation | SIGNOR_ProtMapperSIGNORProtMapper | ProtMapper:14697653SIGNOR:14697653 |
| APBB1 | MAPK3 | P27361 | S | 347 | phosphorylation | SIGNOR_ProtMapperSIGNORProtMapper | ProtMapper:14697653SIGNOR:14697653 |
| APBB1 | MAPK3 | P27361 | S | 175 | phosphorylation | SIGNOR_ProtMapperSIGNORProtMapper | ProtMapper:14697653SIGNOR:14697653 |
| APBB1 | MAPK3 | P27361 | T | 709 | phosphorylation | SIGNOR_ProtMapperProtMapper | ProtMapper:14697653 |
| APBB1 | SGK1 | O00141 | S | 610 | phosphorylation | Sparser_ProtMapperProtMapperRLIMS-P_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:26188042 |
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Ligand-Receptor Signaling (7)
7 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
Regulatory Interaction Network (6)
6 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| ABL1 | P00519 | APBB1 | O00213 | Yes | Yes | No | Sparser_ProtMapperiPTMnetPhosphoPointSIGNORProtMapperHPRDdbPTMKEAphosphoELM_KEASIGNOR_ProtMapperREACH_ProtMapperSPIKESPIKE_LC | SPIKE_LC:15031292ProtMapper:20110615HPRD:11279131ProtMapper:22506131SIGNOR:15031292SPIKE_LC:20841568ProtMapper:26255939dbPTM:15031292KEA:15031292SPIKE:20841568dbPTM:18922798ProtMapper:15031292SPIKE:15031292 |
| APBB1 | O00213 | TSH3 | Q63HK5 | Yes | Yes | No | SIGNOR | SIGNOR:19343227 |
| SGK1 | O00141 | APBB1 | O00213 | Yes | No | Yes | Sparser_ProtMapperiPTMnetSIGNORProtMapperRLIMS-P_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | PhosphoSite:26188042ProtMapper:26188042SIGNOR:26188042 |
| MK01 | P28482 | APBB1 | O00213 | Yes | Yes | No | WangPhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPPhosphoSite_norefSIGNORiPTMnetProtMapperPhosphoSite_KEAKEAphosphoELM_KEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | KEA:14697653SIGNOR:14697653PhosphoSite:14697653ProtMapper:14697653phosphoELM:14697653 |
| GSK3B | P49841 | APBB1 | O00213 | Yes | Yes | No | Sparser_ProtMapperSIGNORProtMapperRLIMS-P_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | PhosphoSite:28963516ProtMapper:28963516SIGNOR:28963516 |
| ATM | Q13315 | APBB1 | O00213 | Yes | No | No | PhosphoSitePhosphoSite_ProtMapperProtMapper | PhosphoSite:25397632PhosphoSite:27176072 |
Protein Complex Composition (10)
10 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| APBB1-TSHZ3-HDAC1 complex | APBB1HDAC1TSHZ3 | O00213Q13547Q63HK5 | 1:1:1 | CompleatCORUM | Compleat:HC888CORUM:5870 | 19343227 |
| APP-APBB1-KAT5 complex | APBB1APPKAT5 | O00213P05067Q92993 | 0:0:0 | CORUM | CORUM:7577 | 11441186 |
| RIAM-Rap1-GTP complex | APBB1IPRAP1A | P62834Q7Z5R6 | 1:1 | CompleatCORUM | Compleat:HC882CORUM:2256 | 15469846 |
| RIAM-Rap1-GTP-profilin complex | APBB1IPPFN1RAP1A | P07737P62834Q7Z5R6 | 1:1:1 | CompleatCORUM | Compleat:HC12CORUM:3158 | 15469846 |
| RIAM-profilin complex | APBB1IPPFN1 | P07737Q7Z5R6 | 1:1 | CompleatCORUM | CORUM:3159Compleat:HC586 | 15469846 |
| APBB1 | O00213 | 8 | PDB | PDB:3d8dPDB:3d8fPDB:2idhPDB:5nqhPDB:3d8e | ||
| APBB1APP | O00213P05067 | 2:2 | PDB | PDB:3dxdPDB:3dxePDB:3dxc | ||
| APBB1SYDE1 | O00213Q6ZW31 | 0:0 | hu.MAP2 | |||
| APBB1IPPLEKHH1 | Q7Z5R6Q9ULM0 | 0:0 | hu.MAPhu.MAP2 | |||
| APBB1IPTLN1 | Q7Z5R6Q9Y490 | 1:1 | PDB | PDB:2mwn |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Polymer Precipitation | Western blotting | 1 | 38731868 |
Sequence, Structure & Domains12
Sequences
Length
710
Mass
77,244
Sequence
MSVPSSLSQSAINANSHGGPALSLPLPLHAAHNQLLNAKLQATAVGPKDLRSAMGEGGGPEPGPANAKWLKEGQNQLRRAATAHRDQNRNVTLTLAEEASQEPEMAPLGPKGLIHLYSELELSAHNAANRGLRGPGLIISTQEQGPDEGEEKAAGEAEEEEEDDDDEEEEEDLSSPPGLPEPLESVEAPPRPQALTDGPREHSKSASLLFGMRNSAASDEDSSWATLSQGSPSYGSPEDTDSFWNPNAFETDSDLPAGWMRVQDTSGTYYWHIPTGTTQWEPPGRASPSQGSSPQEESQLTWTGFAHGEGFEDGEFWKDEPSDEAPMELGLKEPEEGTLTFPAQSLSPEPLPQEEEKLPPRNTNPGIKCFAVRSLGWVEMTEEELAPGRSSVAVNNCIRQLSYHKNNLHDPMSGGWGEGKDLLLQLEDETLKLVEPQSQALLHAQPIISIRVWGVGRDSGRERDFAYVARDKLTQMLKCHVFRCEAPAKNIATSLHEICSKIMAERRNARCLVNGLSLDHSKLVDVPFQVEFPAPKNELVQKFQVYYLGNVPVAKPVGVDVINGALESVLSSSSREQWTPSHVSVAPATLTILHQQTEAVLGECRVRFLSFLAVGRDVHTFAFIMAAGPASFCCHMFWCEPNAASLSEAVQAACMLRYQKCLDARSQASTSCLPAPPAESVARRVGWTVRRGVQSLWGSLKPKRLGAHTP
Alternative Products
Event=Alternative splicing; Named isoforms=6; Name=1; IsoId=O00213-1; Sequence=Displayed; Name=2; IsoId=O00213-2; Sequence=VSP_011658; Name=3; IsoId=O00213-3; Sequence=VSP_045326, VSP_045327, VSP_011658; Name=4; Synonyms=p60Fe65; IsoId=O00213-4; Sequence=VSP_047459; Name=5; IsoId=O00213-5; Sequence=VSP_045326, VSP_045327; Name=6; IsoId=O00213-6; Sequence=VSP_054709
Alternative Sequence
1..259; Missing (in isoform 4); 1..240; MSVPSSLSQSAINANSHGGPALSLPLPLHAAHNQLLNAKLQATAVGPKDLRSAMGEGGGPEPGPANAKWLKEGQNQLRRAATAHRDQNRNVTLTLAEEASQEPEMAPLGPKGLIHLYSELELSAHNAANRGLRGPGLIISTQEQGPDEGEEKAAGEAEEEEEDDDDEEEEEDLSSPPGLPEPLESVEAPPRPQALTDGPREHSKSASLLFGMRNSAASDEDSSWATLSQGSPSYGSPEDT -> MTQMR (in isoform 6); 1..213; Missing (in isoform 3 and isoform 5); 214..240; NSAASDEDSSWATLSQGSPSYGSPEDT -> MSAMFSQDFFLAIILQDSSA (in isoform 3 and isoform 5); 462..463; Missing (in isoform 2 and isoform 3)
3D Structural Models
Turn
273..275; 387..389; 436..438; 472..474; 595..597
Helix
382..385; 390..401; 447..449; 488..504; 559..571; 575..577; 606..608; 644..665
Beta Strand
259..263; 268..272; 278..281; 368..379; 421..427; 430..434; 441..446; 452..455; 458..460; 464..470; 477..486; 544..554; 579..585; 587..594; 600..605; 609..614; 620..628; 631..641
3D Structure
NMR spectroscopy (1); X-ray crystallography (10)
Domain & Motif Annotations
Compositional Bias
1..15; Polar residues; 145..173; Acidic residues; 223..234; Polar residues; 287..299; Low complexity
Domain (FT)
253..285; WW; 370..509; PID 1; 542..699; PID 2
Region
1..24; Disordered; 131..254; Disordered; 276..299; Disordered; 340..365; Disordered
Clinical Relevance5
Drugs (46)
FILOREXANTNULLSB-334867[3H]-ALMOREXANTSB-649868DARIDOREXANTCVN45502ALMOREXANTRTOXA-43SELTOREXANTCLOFARABINEFIRAZOREXTONT-516[3H]CP-1MK-1064EMPAACT-462206SB-408124[3H]-TCS 1102[125I]OREXIN A (HUMAN, MOUSE, RAT)TCS-OX2-29SB-674042RNR INHIBITOR COH29JNJ-10397049LEMBOREXANTHTL6641JH112DANAVOREXTON[3H]T-516OREXIN-AOREXIN-BNAG 26TRIMETHOPRIM/SULFADOXINE[ALA11, D-LEU15]OREXIN-BCP-1LSN2424100COMPOUND 11 [PMID: 15261275](R)-YNT-3708COMPOUND 1 [PMID: 33547286]SUVOREXANT[3H]EMPAYNT-185MK-3697TCS 1102ACT-335827[3H]SB-674042
Interaction Protein (4)
ENSG00000084234ENSG00000123384ENSG00000142192ENSG00000165527
Interaction Count
4
Interaction Dataset
intact_biogrid
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 37427430 | Multiomics of Tissue Extracellular Vesicles Identifies Unique Modulators of Atherosclerosis and Calcific Aortic Valve Stenosis. | No abstract available |