Protein detail
APBB1
Amyloid beta precursor protein binding family B member 1 (Amyloid-beta A4 precursor protein-binding family B member 1) (Protein Fe65)
Entry name APBB1 | UniProt ID | EVMP score 0.38 |
Frequency 1 | Transmembrane count | Protein classification Plasma proteinsPredicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Amyloid beta precursor protein binding family B member 1 (Amyloid-beta A4 precursor protein-binding family B member 1) (Protein Fe65)
Protein Class
Plasma proteinsPredicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
Fe65RIR
Gene Description
Amyloid beta precursor protein binding family B member 1
Chromosome
11
Position
6395125-6419414
Frequency
1
EVMP Score
0.38
Fluorescence & Localization
Cell SpecificPancreatic duct cellsSecretome LocationIntracellular and membraneSecretome FunctionOther
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component
Molecular Function
- GO:0001540 amyloid-beta binding
- GO:0003682 chromatin binding
- GO:0003713 transcription coactivator activity
- GO:0005515 protein binding
- GO:0031625 ubiquitin protein ligase binding
- GO:0042393 histone binding
- GO:0050750 low-density lipoprotein particle receptor binding
- GO:0060090 molecular adaptor activity
- GO:0070064 proline-rich region binding
Biological Process
Reactome
Mediation Categories
Fusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
20 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| APBB1 | GSK3B | P49841 | T | 579 | phosphorylation | Sparser_ProtMapperProtMapperRLIMS-P_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:28963516 |
| APBB1 | ATR | Q13535 | S | 228 | phosphorylation | PhosphoSite | |
| APBB1 | ATM | Q13315 | S | 228 | phosphorylation | PhosphoSite | |
| APBB1 | CDK5 | Q00535 | S | 175 | phosphorylation | PhosphoNetworks | |
| APBB1 | CDK5 | Q00535 | S | 287 | phosphorylation | PhosphoNetworks | |
| APBB1 | CDK5 | Q00535 | S | 347 | phosphorylation | PhosphoNetworks | |
| APBB1 | MAPK8 | P45983 | S | 175 | phosphorylation | PhosphoNetworks | |
| APBB1 | MAPK8 | P45983 | S | 287 | phosphorylation | PhosphoNetworks | |
| APBB1 | MAPK8 | P45983 | S | 347 | phosphorylation | PhosphoNetworks | |
| APBB1 | MAPK8 | P45983 | T | 707 | phosphorylation | PhosphoNetworks |
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Ligand-Receptor Signaling
7 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
6 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| ABL1 | P00519 | APBB1 | O00213 | Yes | Yes | No | Sparser_ProtMapperiPTMnetPhosphoPointSIGNORProtMapperHPRDdbPTMKEAphosphoELM_KEASIGNOR_ProtMapperREACH_ProtMapperSPIKESPIKE_LC | SPIKE_LC:15031292ProtMapper:20110615HPRD:11279131ProtMapper:22506131SIGNOR:15031292SPIKE_LC:20841568ProtMapper:26255939dbPTM:15031292KEA:15031292SPIKE:20841568dbPTM:18922798ProtMapper:15031292SPIKE:15031292 |
| APBB1 | O00213 | TSH3 | Q63HK5 | Yes | Yes | No | SIGNOR | SIGNOR:19343227 |
| SGK1 | O00141 | APBB1 | O00213 | Yes | No | Yes | Sparser_ProtMapperiPTMnetSIGNORProtMapperRLIMS-P_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | PhosphoSite:26188042ProtMapper:26188042SIGNOR:26188042 |
| MK01 | P28482 | APBB1 | O00213 | Yes | Yes | No | WangPhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPPhosphoSite_norefSIGNORiPTMnetProtMapperPhosphoSite_KEAKEAphosphoELM_KEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | KEA:14697653SIGNOR:14697653PhosphoSite:14697653ProtMapper:14697653phosphoELM:14697653 |
| GSK3B | P49841 | APBB1 | O00213 | Yes | Yes | No | Sparser_ProtMapperSIGNORProtMapperRLIMS-P_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | PhosphoSite:28963516ProtMapper:28963516SIGNOR:28963516 |
| ATM | Q13315 | APBB1 | O00213 | Yes | No | No | PhosphoSitePhosphoSite_ProtMapperProtMapper | PhosphoSite:25397632PhosphoSite:27176072 |
Protein Complex Composition
10 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| APBB1-TSHZ3-HDAC1 complex | APBB1HDAC1TSHZ3 | O00213Q13547Q63HK5 | 1:1:1 | CompleatCORUM | Compleat:HC888CORUM:5870 | 19343227 |
| APP-APBB1-KAT5 complex | APBB1APPKAT5 | O00213P05067Q92993 | 0:0:0 | CORUM | CORUM:7577 | 11441186 |
| RIAM-Rap1-GTP complex | APBB1IPRAP1A | P62834Q7Z5R6 | 1:1 | CompleatCORUM | Compleat:HC882CORUM:2256 | 15469846 |
| RIAM-Rap1-GTP-profilin complex | APBB1IPPFN1RAP1A | P07737P62834Q7Z5R6 | 1:1:1 | CompleatCORUM | Compleat:HC12CORUM:3158 | 15469846 |
| RIAM-profilin complex | APBB1IPPFN1 | P07737Q7Z5R6 | 1:1 | CompleatCORUM | CORUM:3159Compleat:HC586 | 15469846 |
| APBB1 | O00213 | 8 | PDB | PDB:3d8dPDB:3d8fPDB:2idhPDB:5nqhPDB:3d8e | ||
| APBB1APP | O00213P05067 | 2:2 | PDB | PDB:3dxdPDB:3dxePDB:3dxc | ||
| APBB1SYDE1 | O00213Q6ZW31 | 0:0 | hu.MAP2 | |||
| APBB1IPPLEKHH1 | Q7Z5R6Q9ULM0 | 0:0 | hu.MAPhu.MAP2 | |||
| APBB1IPTLN1 | Q7Z5R6Q9Y490 | 1:1 | PDB | PDB:2mwn |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Polymer Precipitation | Western blotting | 1 | 38731868 |
Sequence, Structure & Domains
Sequences
Length
710
Mass
77,244
Sequence
MSVPSSLSQSAINANSHGGPALSLPLPLHAAHNQLLNAKLQATAVGPKDLRSAMGEGGGPEPGPANAKWLKEGQNQLRRAATAHRDQNRNVTLTLAEEASQEPEMAPLGPKGLIHLYSELELSAHNAANRGLRGPGLIISTQEQGPDEGEEKAAGEAEEEEEDDDDEEEEEDLSSPPGLPEPLESVEAPPRPQALTDGPREHSKSASLLFGMRNSAASDEDSSWATLSQGSPSYGSPEDTDSFWNPNAFETDSDLPAGWMRVQDTSGTYYWHIPTGTTQWEPPGRASPSQGSSPQEESQLTWTGFAHGEGFEDGEFWKDEPSDEAPMELGLKEPEEGTLTFPAQSLSPEPLPQEEEKLPPRNTNPGIKCFAVRSLGWVEMTEEELAPGRSSVAVNNCIRQLSYHKNNLHDPMSGGWGEGKDLLLQLEDETLKLVEPQSQALLHAQPIISIRVWGVGRDSGRERDFAYVARDKLTQMLKCHVFRCEAPAKNIATSLHEICSKIMAERRNARCLVNGLSLDHSKLVDVPFQVEFPAPKNELVQKFQVYYLGNVPVAKPVGVDVINGALESVLSSSSREQWTPSHVSVAPATLTILHQQTEAVLGECRVRFLSFLAVGRDVHTFAFIMAAGPASFCCHMFWCEPNAASLSEAVQAACMLRYQKCLDARSQASTSCLPAPPAESVARRVGWTVRRGVQSLWGSLKPKRLGAHTP
Alternative Products
Event=Alternative splicing; Named isoforms=6; Name=1; IsoId=O00213-1; Sequence=Displayed; Name=2; IsoId=O00213-2; Sequence=VSP_011658; Name=3; IsoId=O00213-3; Sequence=VSP_045326, VSP_045327, VSP_011658; Name=4; Synonyms=p60Fe65; IsoId=O00213-4; Sequence=VSP_047459; Name=5; IsoId=O00213-5; Sequence=VSP_045326, VSP_045327; Name=6; IsoId=O00213-6; Sequence=VSP_054709
Alternative Sequence
1..259; Missing (in isoform 4); 1..240; MSVPSSLSQSAINANSHGGPALSLPLPLHAAHNQLLNAKLQATAVGPKDLRSAMGEGGGPEPGPANAKWLKEGQNQLRRAATAHRDQNRNVTLTLAEEASQEPEMAPLGPKGLIHLYSELELSAHNAANRGLRGPGLIISTQEQGPDEGEEKAAGEAEEEEEDDDDEEEEEDLSSPPGLPEPLESVEAPPRPQALTDGPREHSKSASLLFGMRNSAASDEDSSWATLSQGSPSYGSPEDT -> MTQMR (in isoform 6); 1..213; Missing (in isoform 3 and isoform 5); 214..240; NSAASDEDSSWATLSQGSPSYGSPEDT -> MSAMFSQDFFLAIILQDSSA (in isoform 3 and isoform 5); 462..463; Missing (in isoform 2 and isoform 3)
3D Structural Models
Turn
273..275; 387..389; 436..438; 472..474; 595..597
Helix
382..385; 390..401; 447..449; 488..504; 559..571; 575..577; 606..608; 644..665
Beta Strand
259..263; 268..272; 278..281; 368..379; 421..427; 430..434; 441..446; 452..455; 458..460; 464..470; 477..486; 544..554; 579..585; 587..594; 600..605; 609..614; 620..628; 631..641
3D Structure
NMR spectroscopy (1); X-ray crystallography (10)
Domain & Motif Annotations
Compositional Bias
1..15; Polar residues; 145..173; Acidic residues; 223..234; Polar residues; 287..299; Low complexity
Domain (FT)
253..285; WW; 370..509; PID 1; 542..699; PID 2
Region
1..24; Disordered; 131..254; Disordered; 276..299; Disordered; 340..365; Disordered
Clinical Relevance
Drugs
FILOREXANTNULLSB-334867[3H]-ALMOREXANTSB-649868DARIDOREXANTCVN45502ALMOREXANTRTOXA-43SELTOREXANTCLOFARABINEFIRAZOREXTONT-516[3H]CP-1MK-1064EMPAACT-462206SB-408124[3H]-TCS 1102[125I]OREXIN A (HUMAN, MOUSE, RAT)TCS-OX2-29SB-674042RNR INHIBITOR COH29JNJ-10397049LEMBOREXANTHTL6641JH112DANAVOREXTON[3H]T-516OREXIN-AOREXIN-BNAG 26TRIMETHOPRIM/SULFADOXINE[ALA11, D-LEU15]OREXIN-BCP-1LSN2424100COMPOUND 11 [PMID: 15261275](R)-YNT-3708COMPOUND 1 [PMID: 33547286]SUVOREXANT[3H]EMPAYNT-185MK-3697TCS 1102ACT-335827[3H]SB-674042
Interaction Protein
ENSG00000084234ENSG00000123384ENSG00000142192ENSG00000165527
Interaction Count
4
Interaction Dataset
intact_biogrid