Protein detail
PODXL
Podocalyxin (GCTM-2 antigen) (Gp200) (Podocalyxin-like protein 1) (PC) (PCLP-1)
Entry name PODXL | UniProt ID | EVMP confidence score 0.75 |
Supporting publications (n) 24 | Transmembrane count 1 | Protein classification Plasma proteinsPredicted membrane proteinsTransporters |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Podocalyxin (GCTM-2 antigen) (Gp200) (Podocalyxin-like protein 1) (PC) (PCLP-1)
Protein Class (3)
Plasma proteinsPredicted membrane proteinsTransporters
Protein Function
Transporters:Accessory Factors Involved in Transport
Transmembrane
462..482; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym (6)
gp135Gp200PCPCLPPDXPODXL1
Gene Description
Podocalyxin like
Chromosome
7
Position
131500262-131558217
Supporting publications (n)
24
EVMP confidence score
0.75
Fluorescence & Localization
Tissue Specificadipose tissueBrain Regional SpecificthalamusCell SpecificEndometrial luminal cellsSingle-Nuclei Brain Specifichippocampal CA4Secretome LocationSecreted to bloodSecretome FunctionNo annotated function
Function & Pathway
Protein Function
Transporters:Accessory Factors Involved in Transport
Cellular Component (14)
- GO:0001726 ruffle
- GO:0005615 extracellular space
- GO:0005730 nucleolus
- GO:0005737 cytoplasm
- GO:0005886 plasma membrane
- GO:0016324 apical plasma membrane
- GO:0030027 lamellipodium
- GO:0030175 filopodium
- GO:0031528 microvillus membrane
- GO:0034451 centriolar satellite
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Molecular Function
Biological Process (3)
Canonical Pathways (3)
- M5880 Naba ecm affiliated
- M5885 Naba matrisome associated
- M5889 Naba matrisome
Mediation Categories (2)
Adhesion and uptake mediationFusion and delivery mediation
Relations & Evidence35
Ligand-Receptor Signaling (32)
32 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| cell_surface | cell_surface | OmniPath | Yes | Yes | |||
| transmembrane | transmembrane_predicted | Phobius | Yes | Yes |
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Protein Complex Composition (2)
Sequence, Structure & Domains
Sequences
Length
558
Mass
58,635
Sequence
MRCALALSALLLLLSTPPLLPSSPSPSPSPSQNATQTTTDSSNKTAPTPASSVTIMATDTAQQSTVPTSKANEILASVKATTLGVSSDSPGTTTLAQQVSGPVNTTVARGGGSGNPTTTIESPKSTKSADTTTVATSTATAKPNTTSSQNGAEDTTNSGGKSSHSVTTDLTSTKAEHLTTPHPTSPLSPRQPTSTHPVATPTSSGHDHLMKISSSSSTVAIPGYTFTSPGMTTTLLETVFHHVSQAGLELLTSGDLPTLASQSAGITASSVISQRTQQTSSQMPASSTAPSSQETVQPTSPATALRTPTLPETMSSSPTAASTTHRYPKTPSPTVAHESNWAKCEDLETQTQSEKQLVLNLTGNTLCAGGASDEKLISLICRAVKATFNPAQDKCGIRLASVPGSQTVVVKEITIHTKLPAKDVYERLKDKWDELKEAGVSDMKLGDQGPPEEAEDRFSMPLIITIVCMASFLLLVAALYGCCHQRLSQRKDQQRLTEELQTVENGYHDNPTLEVMETSSEMQEKKVVSLNGELGDSWIVPLDNLTKDDLDEEEDTHL
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O00592-1; Sequence=Displayed; Name=2; IsoId=O00592-2; Sequence=VSP_037220
Alternative Sequence
236..268; LETVFHHVSQAGLELLTSGDLPTLASQSAGITA -> P (in isoform 2)
Domain & Motif Annotations
Compositional Bias
20..29; Pro residues; 32..50; Polar residues; 83..107; Polar residues; 125..142; Low complexity; 143..173; Polar residues; 190..204; Polar residues; 270..302; Polar residues; 313..324; Low complexity
Domain (CC)
Both the O-glycan-rich domain of the extracellular domain and the C-terminus PDZ-binding motif (DTHL) in the cytoplasmic tail harbor an apical sorting signal. The cytoplasmic domain is necessary for the apical membrane targeting and renal tubulogenesis. The cytoplasmic C-terminus PDZ-binding motif (DTHL) is essential for interaction with NHERF1 and for targeting NHERF1 to the apical cell membrane. The extracellular domain is necessary for microvillus formation (By similarity). The large highly anionic extracellular domain allows to maintain open filtration pathways between neighboring podocyte foot processes.
Region
20..50; Disordered; 83..210; Disordered; 270..338; Disordered
Protein Families
Podocalyxin family
Sequence Similarities
Belongs to the podocalyxin family.
Clinical Relevance
Supporting Publications24
| PMID | Title | Related sentences |
|---|---|---|
| 27894104 | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. | No related sentences available |
| 28986585 | Quantitation of putative colorectal cancer biomarker candidates in serum extracellular vesicles by targeted proteomics. | No related sentences available |
| 29436780 | Autosomal Tubulointerstitial Kidney Disease-MUC1 Type: Differential Proteomics Suggests that Mutated MUC1 (insC) Affects Vesicular Transport in Renal Epithelial Cells. | No related sentences available |
| 30646616 | Preferential Localization of MUC1 Glycoprotein in Exosomes Secreted by Non-Small Cell Lung Carcinoma Cells. | THBS1, ANXA6, HIST1H4A, COL18A1, MDK, SRGN, ENO1, TUBA4A, SLC3A2, GPI, MIF, MUC1, TALDO1, SLC7A5, ICAM1, HSP90AA1, G6PD, and LRP1 were found to be expressed in exosomes at more than 5-fold higher level as compared to total cellular membrane proteins. |
| 30950185 | Unique Protein Profiles of Extracellular Vesicles as Diagnostic Biomarkers for Early and Advanced Non-Small Cell Lung Cancer. | No related sentences available |
| 31918306 | Potential urinary extracellular vesicle protein biomarkers of chronic active antibody-mediated rejection in kidney transplant recipients. | No related sentences available |
| 31941606 | The role of actinin-4 (ACTN4) in exosomes as a potential novel therapeutic target in castration-resistant prostate cancer. | No related sentences available |
| 32089743 | Human umbilical cord mesenchymal stromal cells-derived extracellular vesicles exert potent bone protective effects by CLEC11A-mediated regulation of bone metabolism. | No related sentences available |
| 32284825 | Unravelling the proteomic landscape of extracellular vesicles in prostate cancer by density-based fractionation of urine. | No related sentences available |
| 32489530 | Quantitative proteomic analysis of trypsin-treated extracellular vesicles to identify the real-vesicular proteins. | No related sentences available |
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