Protein detail
CDIPT
CDP-diacylglycerol--inositol 3-phosphatidyltransferase (EC 2.7.8.11) (Phosphatidylinositol synthase) (PI synthase) (PtdIns synthase)
Protein symbol CDIPT | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 6 | Protein classification EnzymesMetabolic proteinsPredicted membrane proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
CDP-diacylglycerol--inositol 3-phosphatidyltransferase (EC 2.7.8.11) (Phosphatidylinositol synthase) (PI synthase) (PtdIns synthase)
Protein Class
EnzymesMetabolic proteinsPredicted membrane proteins
Protein Function
- ENZYME proteins:Transferases
- Enzymes
Transmembrane
6..26; Helical; 28..48; Helical; 74..94; Helical; 96..116; Helical; 140..160; Helical; 175..195; Helical
Transmembrane Count
6
Ensembl
Entrez Gene Symbol
Gene Synonym
PISPIS1
Gene Description
CDP-diacylglycerol--inositol 3-phosphatidyltransferase
Chromosome
16
Position
29858357-29863414
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Cell SpecificBasal keratinocytesBlood Cell Specificmyeloid DC
Function & Pathway
Protein Function
- ENZYME proteins:Transferases
- Enzymes
Cellular Component
Molecular Function
Biological Process
KEGG
Reactome
Canonical Pathways
- M201 Pid erbb network pathway
- M13 Pid erbb4 pathway
- M175 Pid erbb2 erbb3 pathway
Mediation Categories
Metabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
13 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | No | No |
| transmembrane | transmembrane | LOCATE | No | No | No | No | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | No | No |
| transmembrane | transmembrane | OmniPath | No | No | No | No | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 37403840 |
Sequence, Structure & Domains
Sequences
Length
213
Mass
23,539
Sequence
MPDENIFLFVPNLIGYARIVFAIISFYFMPCCPLTASSFYLLSGLLDAFDGHAARALNQGTRFGAMLDMLTDRCSTMCLLVNLALLYPGATLFFQISMSLDVASHWLHLHSSVVRGSESHKMIDLSGNPVLRIYYTSRPALFTLCAGNELFYCLLYLFHFSEGPLVGSVGLFRMGLWVTAPIALLKSLISVIHLITAARNMAALDAADRAKKK
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=O14735-1; Sequence=Displayed; Name=2; IsoId=O14735-2; Sequence=VSP_013618, VSP_013619, VSP_013620; Name=3; IsoId=O14735-3; Sequence=VSP_054767
Alternative Sequence
1..14; MPDENIFLFVPNLI -> MLPTAAGFSIWGQVGAAREAPRCQTKISSCSCPTSSVSAAHGPGPNERARGLGGLPDPALSPRVPFQ (in isoform 2); 15..59; Missing (in isoform 3); 111..129; SSVVRGSESHKMIDLSGNP -> RSAAILGAWATWRHYSGVG (in isoform 2); 130..213; Missing (in isoform 2)
3D Structural Models
Domain & Motif Annotations
Protein Families
CDP-alcohol phosphatidyltransferase class-I family
Sequence Similarities
Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
Clinical Relevance
Antibody