Protein detail
CDIPT
CDP-diacylglycerol--inositol 3-phosphatidyltransferase (EC 2.7.8.11) (Phosphatidylinositol synthase) (PI synthase) (PtdIns synthase)
Entry name CDIPT | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 1 | Transmembrane count 6 | Protein classification EnzymesMetabolic proteinsPredicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
CDP-diacylglycerol--inositol 3-phosphatidyltransferase (EC 2.7.8.11) (Phosphatidylinositol synthase) (PI synthase) (PtdIns synthase)
Protein Class (3)
EnzymesMetabolic proteinsPredicted membrane proteins
Protein Function (2)
- ENZYME proteins:Transferases
- Enzymes
Transmembrane
6..26; Helical; 28..48; Helical; 74..94; Helical; 96..116; Helical; 140..160; Helical; 175..195; Helical
Transmembrane Count
6
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
PISPIS1
Gene Description
CDP-diacylglycerol--inositol 3-phosphatidyltransferase
Chromosome
16
Position
29858357-29863414
Supporting publications (n)
1
EVMP confidence score
0.50
Fluorescence & Localization3
Cell SpecificBasal keratinocytesBlood Cell Specificmyeloid DC
Function & Pathway8
Protein Function (2)
- ENZYME proteins:Transferases
- Enzymes
Cellular Component (4)
Molecular Function (3)
Biological Process (3)
KEGG (4)
Reactome (4)
Canonical Pathways (3)
- M201 Pid erbb network pathway
- M13 Pid erbb4 pathway
- M175 Pid erbb2 erbb3 pathway
Mediation Categories
Metabolism mediation
Relations & Evidence14
Ligand-Receptor Signaling (13)
13 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | No | No |
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Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 37403840 |
Sequence, Structure & Domains7
Sequences
Length
213
Mass
23,539
Sequence
MPDENIFLFVPNLIGYARIVFAIISFYFMPCCPLTASSFYLLSGLLDAFDGHAARALNQGTRFGAMLDMLTDRCSTMCLLVNLALLYPGATLFFQISMSLDVASHWLHLHSSVVRGSESHKMIDLSGNPVLRIYYTSRPALFTLCAGNELFYCLLYLFHFSEGPLVGSVGLFRMGLWVTAPIALLKSLISVIHLITAARNMAALDAADRAKKK
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=O14735-1; Sequence=Displayed; Name=2; IsoId=O14735-2; Sequence=VSP_013618, VSP_013619, VSP_013620; Name=3; IsoId=O14735-3; Sequence=VSP_054767
Alternative Sequence
1..14; MPDENIFLFVPNLI -> MLPTAAGFSIWGQVGAAREAPRCQTKISSCSCPTSSVSAAHGPGPNERARGLGGLPDPALSPRVPFQ (in isoform 2); 15..59; Missing (in isoform 3); 111..129; SSVVRGSESHKMIDLSGNP -> RSAAILGAWATWRHYSGVG (in isoform 2); 130..213; Missing (in isoform 2)
Domain & Motif Annotations
Protein Families
CDP-alcohol phosphatidyltransferase class-I family
Sequence Similarities
Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
Clinical Relevance1
Antibody
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 30550287 | Label-Free Proteomic Analysis of Exosomes Secreted from THP-1-Derived Macrophages Treated with IFN-α Identifies Antiviral Proteins Enriched in Exosomes. | No abstract available |