Protein detail

GIPC1

PDZ domain-containing protein GIPC1 (GAIP C-terminus-interacting protein) (RGS-GAIP-interacting protein) (RGS19-interacting protein 1) (Synectin) (Tax interaction protein 2) (TIP-2)

Entry name GIPC1	UniProt ID O14908	EVMP confidence score 0.60
Supporting publications (n) 12	Transmembrane count	Protein classification Disease related genesHuman disease related genesPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

PDZ domain-containing protein GIPC1 (GAIP C-terminus-interacting protein) (RGS-GAIP-interacting protein) (RGS19-interacting protein 1) (Synectin) (Tax interaction protein 2) (TIP-2)

Protein Class (3)

Disease related genesHuman disease related genesPredicted intracellular proteins

Protein Function (3)

Disease related genes
Predicted intracellular proteins
Human disease related genes:Musculoskeletal diseases:Muscular diseases

Ensembl

ENSG00000123159

Entrez Gene Symbol

GIPC1

Gene Synonym (9)

C19orf3GIPCGLUT1CBPHs.6454NIPRGS19IP1SEMCAPSYNECTINTIP-2

Gene Description

GIPC PDZ domain containing family member 1

Chromosome

Position

14477760-14496149

Supporting publications (n)

EVMP confidence score

0.60

Fluorescence & Localization3

Tissue SpecificbrainCell SpecificBrain excitatory neurons

Function & Pathway6

Protein Function (3)

Disease related genes
Predicted intracellular proteins
Human disease related genes:Musculoskeletal diseases:Muscular diseases

Cellular Component (12)

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Molecular Function (6)

Biological Process (3)

Reactome (9)

Mediation Categories (3)

Fusion and delivery mediationMetabolism mediationReceptor-signaling mediation

Relations & Evidence14

Ligand-Receptor Signaling (4)

4 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Protein Complex Composition (9)

9 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
HT_DM_Cluster500	BTBD19 GIPC1 GIPC2 GIPC3	C9JJ37 O14908 Q8TF64 Q8TF65	1:1:1:1	Compleat	Compleat:HC63	22036573
	APIP DHX15 EGLN1 EML2 ERH GIPC1 HMGB2 SERPINE1 UTP14A	O14908 O43143 O95834 P05121 P26583 P84090 Q96GX9 Q9BVJ6 Q9GZT9	0:0:0:0:0:0:0:0:0	hu.MAP2
	CS GIPC1	O14908 O75390	0:0	hu.MAP
	CS GIPC1 MMUT RAD23B	O14908 O75390 P22033 P54727	0:0:0:0	hu.MAP2
	APIP CS GIPC1 KYNU MMUT RAD23B	O14908 O75390 P22033 P54727 Q16719 Q96GX9	0:0:0:0:0:0	hu.MAP2
	APIP CS GIPC1 KYNU MMUT	O14908 O75390 P22033 Q16719 Q96GX9	0:0:0:0:0	hu.MAP2
	FZD3 GIPC1 GIPC3 HECW1 SOD1 SSR4	O14908 P00441 P51571 Q76N89 Q8TF64 Q9NPG1	1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC6646
	FZD3 GIPC1 GIPC3 HECW1 SCYL1 SSR4	O14908 P51571 Q76N89 Q8TF64 Q96KG9 Q9NPG1	1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC9129
	GIPC1 MTERF1 PNPO	O14908 Q99551 Q9NVS9	0:0:0	hu.MAP

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry [LTQ-FT Ultra]Mass spectrometry	3	27487081 35763629 36982312

Sequence, Structure & Domains10

Sequences

Length

333

Mass

36,049

Sequence

MPLGLGRRKKAPPLVENEEAEPGRGGLGVGEPGPLGGGGSGGPQMGLPPPPPALRPRLVFHTQLAHGSPTGRIEGFTNVKELYGKIAEAFRLPTAEVMFCTLNTHKVDMDKLLGGQIGLEDFIFAHVKGQRKEVEVFKSEDALGLTITDNGAGYAFIKRIKEGSVIDHIHLISVGDMIEAINGQSLLGCRHYEVARLLKELPRGRTFTLKLTEPRKAFDMISQRSAGGRPGSGPQLGTGRGTLRLRSRGPATVEDLPSAFEEKAIEKVDDLLESYMGIRDTELAATMVELGKDKRNPDELAEALDERLGDFAFPDEFVFDVWGAIGDAKVGRY

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O14908-1; Sequence=Displayed; Name=2; IsoId=O14908-2; Sequence=VSP_044296

Alternative Sequence

1..97; Missing (in isoform 2)

Domain & Motif Annotations

Compositional Bias

1..11; Basic residues; 23..44; Gly residues; 228..240; Gly residues

Domain (FT)

133..213; PDZ

Region

1..54; Disordered; 223..244; Disordered

Protein Families

GIPC family

Sequence Similarities

Belongs to the GIPC family.

Clinical Relevance5

Disease Involvement (2)

Congenital muscular dystrophyDystroglycanopathy

Antibody (2)

HPA043958 HPA061786

Interaction Protein (8)

ENSG00000100065ENSG00000107165ENSG00000130147ENSG00000136044ENSG00000157500ENSG00000168758ENSG00000196586ENSG00000196914

Interaction Count

Interaction Dataset (4)

intact_biogridintact_biogrid_bioplexbiogrid_bioplexintact_biogrid_opencell

Supporting Publications12

PMID	Title	Abstract
25755179	Urinary extracellular vesicles as reservoirs of altered proteins during the pathogenesis of polycystic kidney disease.	No abstract available
30915084	Extracellular Vesicles Mediate Mesenchymal Stromal Cell-Dependent Regulation of B Cell PI3K-AKT Signaling Pathway and Actin Cytoskeleton.	No abstract available
32560723	T2 and T17 cytokines alter the cargo and function of airway epithelium-derived extracellular vesicles.	No abstract available
33304478	The proteomic landscape of small urinary extracellular vesicles during kidney transplantation.	No abstract available
34473505	Column-based Technology for CD9-HPLC Immunoaffinity Isolation of Serum Extracellular Vesicles.	No abstract available
36064647	Systemic proteomics and miRNA profile analysis of exosomes derived from human pluripotent stem cells.	No abstract available
36146834	Human Cytomegalovirus Modifies Placental Small Extracellular Vesicle Composition to Enhance Infection of Fetal Neural Cells In Vitro.	No abstract available
36982312	Saliva and Saliva Extracellular Vesicles for Biomarker Candidate Identification-Assay Development and Pilot Study in Amyotrophic Lateral Sclerosis.	No abstract available
37322475	Comprehensive profiling of extracellular vesicles in uveitis and scleritis enables biomarker discovery and mechanism exploration.	No abstract available
38113368	In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum.	No abstract available

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