Protein detail

GIPC1

PDZ domain-containing protein GIPC1 (GAIP C-terminus-interacting protein) (RGS-GAIP-interacting protein) (RGS19-interacting protein 1) (Synectin) (Tax interaction protein 2) (TIP-2)

Entry name
GIPC1
UniProt ID
O14908
EVMP confidence score
0.72
Supporting publications (n)
12
Transmembrane count
Protein classification
Disease related genesHuman disease related genesPredicted intracellular proteins
Basic Information
Protein Names
PDZ domain-containing protein GIPC1 (GAIP C-terminus-interacting protein) (RGS-GAIP-interacting protein) (RGS19-interacting protein 1) (Synectin) (Tax interaction protein 2) (TIP-2)
Protein Class (3)
Disease related genesHuman disease related genesPredicted intracellular proteins
Protein Function (3)
  • Disease related genes
  • Predicted intracellular proteins
  • Human disease related genes:Musculoskeletal diseases:Muscular diseases
Ensembl
ENSG00000123159
Entrez Gene Symbol
GIPC1
Gene Synonym (9)
C19orf3GIPCGLUT1CBPHs.6454NIPRGS19IP1SEMCAPSYNECTINTIP-2
Gene Description
GIPC PDZ domain containing family member 1
Chromosome
19
Position
14477760-14496149
Supporting publications (n)
12
EVMP confidence score
0.72
Fluorescence & Localization
GIPC1 fluorescence
Tissue SpecificbrainCell SpecificBrain excitatory neurons
Function & Pathway
Protein Function (3)
  • Disease related genes
  • Predicted intracellular proteins
  • Human disease related genes:Musculoskeletal diseases:Muscular diseases
Cellular Component (12)
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Molecular Function (6)
Biological Process (3)
Reactome (9)
Mediation Categories (3)
Fusion and delivery mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence14

Ligand-Receptor Signaling (4)

4 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
intracellularintracellularComPPI
intracellularintracellularGO_Intercell
intracellularintracellularUniProt_location
intracellularintracellularOmniPath

Protein Complex Composition (9)

9 records.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
HT_DM_Cluster500BTBD19GIPC1GIPC2GIPC3C9JJ37O14908Q8TF64Q8TF651:1:1:1CompleatCompleat:HC6322036573
APIPDHX15EGLN1EML2ERHGIPC1HMGB2SERPINE1UTP14AO14908O43143O95834P05121P26583P84090Q96GX9Q9BVJ6Q9GZT90:0:0:0:0:0:0:0:0hu.MAP2
CSGIPC1O14908O753900:0hu.MAP
CSGIPC1MMUTRAD23BO14908O75390P22033P547270:0:0:0hu.MAP2
APIPCSGIPC1KYNUMMUTRAD23BO14908O75390P22033P54727Q16719Q96GX90:0:0:0:0:0hu.MAP2
APIPCSGIPC1KYNUMMUTO14908O75390P22033Q16719Q96GX90:0:0:0:0hu.MAP2
FZD3GIPC1GIPC3HECW1SOD1SSR4O14908P00441P51571Q76N89Q8TF64Q9NPG11:1:1:1:1:1NetworkBlastCompleatCompleat:HC6646
FZD3GIPC1GIPC3HECW1SCYL1SSR4O14908P51571Q76N89Q8TF64Q96KG9Q9NPG11:1:1:1:1:1NetworkBlastCompleatCompleat:HC9129
GIPC1MTERF1PNPOO14908Q99551Q9NVS90:0:0hu.MAP

Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationSize Exclusion ChromatographyMass spectrometry [LTQ-FT Ultra]Mass spectrometry3274870813576362936982312
Sequence, Structure & Domains

Sequences

Length
333
Mass
36,049
Sequence
MPLGLGRRKKAPPLVENEEAEPGRGGLGVGEPGPLGGGGSGGPQMGLPPPPPALRPRLVFHTQLAHGSPTGRIEGFTNVKELYGKIAEAFRLPTAEVMFCTLNTHKVDMDKLLGGQIGLEDFIFAHVKGQRKEVEVFKSEDALGLTITDNGAGYAFIKRIKEGSVIDHIHLISVGDMIEAINGQSLLGCRHYEVARLLKELPRGRTFTLKLTEPRKAFDMISQRSAGGRPGSGPQLGTGRGTLRLRSRGPATVEDLPSAFEEKAIEKVDDLLESYMGIRDTELAATMVELGKDKRNPDELAEALDERLGDFAFPDEFVFDVWGAIGDAKVGRY
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O14908-1; Sequence=Displayed; Name=2; IsoId=O14908-2; Sequence=VSP_044296
Alternative Sequence
1..97; Missing (in isoform 2)

Domain & Motif Annotations

Compositional Bias
1..11; Basic residues; 23..44; Gly residues; 228..240; Gly residues
Domain (FT)
133..213; PDZ
Region
1..54; Disordered; 223..244; Disordered
Protein Families
GIPC family
Sequence Similarities
Belongs to the GIPC family.
Clinical Relevance
Disease Involvement (2)
Congenital muscular dystrophyDystroglycanopathy
Related Diseases (2)
Congenital muscular dystrophyDystroglycanopathy
Antibody (2)
HPA043958HPA061786
Interaction Protein (8)
ENSG00000100065ENSG00000107165ENSG00000130147ENSG00000136044ENSG00000157500ENSG00000168758ENSG00000196586ENSG00000196914
Interaction Count
8
Interaction Dataset (4)
intact_biogridintact_biogrid_bioplexbiogrid_bioplexintact_biogrid_opencell
Supporting Publications12
PMIDTitleRelated sentences
25755179Urinary extracellular vesicles as reservoirs of altered proteins during the pathogenesis of polycystic kidney disease.No related sentences available
30915084Extracellular Vesicles Mediate Mesenchymal Stromal Cell-Dependent Regulation of B Cell PI3K-AKT Signaling Pathway and Actin Cytoskeleton.No related sentences available
32560723T2 and T17 cytokines alter the cargo and function of airway epithelium-derived extracellular vesicles.No related sentences available
33304478The proteomic landscape of small urinary extracellular vesicles during kidney transplantation.No related sentences available
34473505Column-based Technology for CD9-HPLC Immunoaffinity Isolation of Serum Extracellular Vesicles.Column-based Technology for CD9-HPLC Immunoaffinity Isolation of Serum Extracellular Vesicles.
36064647Systemic proteomics and miRNA profile analysis of exosomes derived from human pluripotent stem cells.No related sentences available
36146834Human Cytomegalovirus Modifies Placental Small Extracellular Vesicle Composition to Enhance Infection of Fetal Neural Cells In Vitro.No related sentences available
36982312Saliva and Saliva Extracellular Vesicles for Biomarker Candidate Identification-Assay Development and Pilot Study in Amyotrophic Lateral Sclerosis.No related sentences available
37322475Comprehensive profiling of extracellular vesicles in uveitis and scleritis enables biomarker discovery and mechanism exploration.No related sentences available
38113368In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum.No related sentences available
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