Protein detail
GIPC1
PDZ domain-containing protein GIPC1 (GAIP C-terminus-interacting protein) (RGS-GAIP-interacting protein) (RGS19-interacting protein 1) (Synectin) (Tax interaction protein 2) (TIP-2)
Entry name GIPC1 | UniProt ID | EVMP confidence score 0.72 |
Supporting publications (n) 12 | Transmembrane count | Protein classification Disease related genesHuman disease related genesPredicted intracellular proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
PDZ domain-containing protein GIPC1 (GAIP C-terminus-interacting protein) (RGS-GAIP-interacting protein) (RGS19-interacting protein 1) (Synectin) (Tax interaction protein 2) (TIP-2)
Protein Class (3)
Disease related genesHuman disease related genesPredicted intracellular proteins
Protein Function (3)
- Disease related genes
- Predicted intracellular proteins
- Human disease related genes:Musculoskeletal diseases:Muscular diseases
Ensembl
Entrez Gene Symbol
Gene Synonym (9)
C19orf3GIPCGLUT1CBPHs.6454NIPRGS19IP1SEMCAPSYNECTINTIP-2
Gene Description
GIPC PDZ domain containing family member 1
Chromosome
19
Position
14477760-14496149
Supporting publications (n)
12
EVMP confidence score
0.72
Fluorescence & Localization
Tissue SpecificbrainCell SpecificBrain excitatory neurons
Function & Pathway
Protein Function (3)
- Disease related genes
- Predicted intracellular proteins
- Human disease related genes:Musculoskeletal diseases:Muscular diseases
Cellular Component (12)
- GO:0005737 cytoplasm
- GO:0005829 cytosol
- GO:0005938 cell cortex
- GO:0008021 synaptic vesicle
- GO:0012506 vesicle membrane
- GO:0016020 membrane
- GO:0031410 cytoplasmic vesicle
- GO:0043197 dendritic spine
- GO:0043198 dendritic shaft
- GO:0070062 extracellular exosome
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Molecular Function (6)
Biological Process (3)
Reactome (9)
- R-hsa-190370 fgfr1b ligand binding and activation
- R-hsa-190373 fgfr1c ligand binding and activation
- R-hsa-190242 fgfr1 ligand binding and activation
- R-hsa-190236 signaling by fgfr
- R-hsa-5654736 signaling by fgfr1
- R-hsa-9006934 signaling by receptor tyrosine kinases
- R-hsa-9839373 signaling by tgfbr3
- R-hsa-9006936 signaling by tgfb family members
- R-hsa-9839389 tgfbr3 regulates tgf beta signaling
Mediation Categories (3)
Fusion and delivery mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence14
Ligand-Receptor Signaling (4)
4 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | |||||
| intracellular | intracellular | GO_Intercell | |||||
| intracellular | intracellular | UniProt_location | |||||
| intracellular | intracellular | OmniPath |
Protein Complex Composition (9)
9 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| HT_DM_Cluster500 | BTBD19GIPC1GIPC2GIPC3 | C9JJ37O14908Q8TF64Q8TF65 | 1:1:1:1 | Compleat | Compleat:HC63 | 22036573 |
| APIPDHX15EGLN1EML2ERHGIPC1HMGB2SERPINE1UTP14A | O14908O43143O95834P05121P26583P84090Q96GX9Q9BVJ6Q9GZT9 | 0:0:0:0:0:0:0:0:0 | hu.MAP2 | |||
| CSGIPC1 | O14908O75390 | 0:0 | hu.MAP | |||
| CSGIPC1MMUTRAD23B | O14908O75390P22033P54727 | 0:0:0:0 | hu.MAP2 | |||
| APIPCSGIPC1KYNUMMUTRAD23B | O14908O75390P22033P54727Q16719Q96GX9 | 0:0:0:0:0:0 | hu.MAP2 | |||
| APIPCSGIPC1KYNUMMUT | O14908O75390P22033Q16719Q96GX9 | 0:0:0:0:0 | hu.MAP2 | |||
| FZD3GIPC1GIPC3HECW1SOD1SSR4 | O14908P00441P51571Q76N89Q8TF64Q9NPG1 | 1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC6646 | ||
| FZD3GIPC1GIPC3HECW1SCYL1SSR4 | O14908P51571Q76N89Q8TF64Q96KG9Q9NPG1 | 1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC9129 | ||
| GIPC1MTERF1PNPO | O14908Q99551Q9NVS9 | 0:0:0 | hu.MAP |
Sequence, Structure & Domains
Sequences
Length
333
Mass
36,049
Sequence
MPLGLGRRKKAPPLVENEEAEPGRGGLGVGEPGPLGGGGSGGPQMGLPPPPPALRPRLVFHTQLAHGSPTGRIEGFTNVKELYGKIAEAFRLPTAEVMFCTLNTHKVDMDKLLGGQIGLEDFIFAHVKGQRKEVEVFKSEDALGLTITDNGAGYAFIKRIKEGSVIDHIHLISVGDMIEAINGQSLLGCRHYEVARLLKELPRGRTFTLKLTEPRKAFDMISQRSAGGRPGSGPQLGTGRGTLRLRSRGPATVEDLPSAFEEKAIEKVDDLLESYMGIRDTELAATMVELGKDKRNPDELAEALDERLGDFAFPDEFVFDVWGAIGDAKVGRY
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O14908-1; Sequence=Displayed; Name=2; IsoId=O14908-2; Sequence=VSP_044296
Alternative Sequence
1..97; Missing (in isoform 2)
Domain & Motif Annotations
Compositional Bias
1..11; Basic residues; 23..44; Gly residues; 228..240; Gly residues
Domain (FT)
133..213; PDZ
Region
1..54; Disordered; 223..244; Disordered
Protein Families
GIPC family
Sequence Similarities
Belongs to the GIPC family.
Clinical Relevance
Disease Involvement (2)
Congenital muscular dystrophyDystroglycanopathy
Related Diseases (2)
Interaction Protein (8)
ENSG00000100065ENSG00000107165ENSG00000130147ENSG00000136044ENSG00000157500ENSG00000168758ENSG00000196586ENSG00000196914
Interaction Count
8
Interaction Dataset (4)
intact_biogridintact_biogrid_bioplexbiogrid_bioplexintact_biogrid_opencell
Supporting Publications12
| PMID | Title | Related sentences |
|---|---|---|
| 38207106 | Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity. | No related sentences available |
| 40189497 | Small extracellular vesicle-based one-step high-throughput microfluidic platform for epithelial ovarian cancer diagnosis. | No related sentences available |
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