Protein detail

PGRC2

Membrane-associated progesterone receptor component 2 (Progesterone membrane-binding protein) (Steroid receptor protein DG6)

Entry name PGRC2	UniProt ID O15173	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count 1	Protein classification Predicted intracellular proteinsPredicted membrane proteinsPredicted secreted proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Membrane-associated progesterone receptor component 2 (Progesterone membrane-binding protein) (Steroid receptor protein DG6)

Protein Class (4)

Predicted intracellular proteinsPredicted membrane proteinsPredicted secreted proteinsTransporters

Protein Function (3)

Predicted secreted proteins
Transporters
Predicted intracellular proteins

Transmembrane

42..66; Helical

Transmembrane Count

Ensembl

ENSG00000164040

Entrez Gene Symbol

PGRMC2

Gene Synonym (2)

DG6PMBP

Gene Description

Progesterone receptor membrane component 2

Chromosome

Position

128269237-128288829

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization4

Tissue SpecificretinaCell SpecificAdrenal medulla cellsSecretome LocationIntracellular and membraneSecretome FunctionOther

Function & Pathway7

Protein Function (3)

Predicted secreted proteins
Transporters
Predicted intracellular proteins

Cellular Component (7)

Molecular Function (5)

Biological Process (3)

KEGG

hsa04080 Neuroactive ligand-receptor interaction

Reactome (9)

Mediation Categories (2)

Fusion and delivery mediationReceptor-signaling mediation

Relations & Evidence20

Ligand-Receptor Signaling (17)

17 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
membrane_associated_progesterone	receptor	OmniPath	No	Yes	Yes	No	No
receptor	receptor	OmniPath	No	Yes	Yes	No	No
intracellular	intracellular	ComPPI	No	No	Yes	No	No
intracellular	intracellular	GO_Intercell	No	No	Yes	No	No
intracellular	intracellular	UniProt_location	No	No	Yes	No	No
intracellular	intracellular	OmniPath	No	No	Yes	No	No
transmembrane	transmembrane	UniProt_location	No	No	Yes	No	No
transmembrane	transmembrane	UniProt_topology	No	No	Yes	No	No
transmembrane	transmembrane	UniProt_keyword	No	No	Yes	No	No
transmembrane	transmembrane	LOCATE	No	No	Yes	No	No

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Protein Complex Composition (2)

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	CANX DDOST JAGN1 MAGT1 PGRMC2 RPN1 SEC61A1 SEC63	O15173 P04843 P27824 P39656 P61619 Q8N5M9 Q9H0U3 Q9UGP8	0:0:0:0:0:0:0:0	hu.MAP2
	DDOST JAGN1 MAGT1 PGRMC2 RPN1 SEC61A1 SEC63	O15173 P04843 P39656 P61619 Q8N5M9 Q9H0U3 Q9UGP8	0:0:0:0:0:0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Size Exclusion Chromatography	Mass SpectrometryElisa	1	38071653

Sequence, Structure & Domains11

Sequences

Length

223

Mass

23,818

Sequence

MAAGDGDVKLGTLGSGSESSNDGGSESPGDAGAAAEGGGWAAAALALLTGGGEMLLNVALVALVLLGAYRLWVRWGRRGLGAGAGAGEESPATSLPRMKKRDFSLEQLRQYDGSRNPRILLAVNGKVFDVTKGSKFYGPAGPYGIFAGRDASRGLATFCLDKDALRDEYDDLSDLNAVQMESVREWEMQFKEKYDYVGRLLKPGEEPSEYTDEEDTKDHNKQD

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O15173-1; Sequence=Displayed; Name=2; IsoId=O15173-2; Sequence=VSP_053500

Alternative Sequence

1; M -> MGGAGRGVGEGRGRGGGGRRWRAVM (in isoform 2)

Domain & Motif Annotations

Compositional Bias

15..33; Low complexity; 206..215; Acidic residues

Domain (CC)

The cytochrome b5 heme-binding domain lacks the conserved iron-binding His residues at positions 137 and 161..

Domain (FT)

102..201; Cytochrome b5 heme-binding

Region

1..33; Disordered; 202..223; Disordered

Protein Families (2)

Cytochrome b5 family
MAPR subfamily

Sequence Similarities

Belongs to the cytochrome b5 family. MAPR subfamily.

Clinical Relevance4

Antibody (2)

HPA041172 HPA058652

Interaction Protein (12)

ENSG00000101193ENSG00000101558ENSG00000101856ENSG00000106803ENSG00000118705ENSG00000121073ENSG00000124783ENSG00000147324ENSG00000148841ENSG00000163902ENSG00000182544ENSG00000185825

Interaction Count

Interaction Dataset (3)

intact_biogridintact_biogrid_opencellbiogrid_opencell

Supporting Publications1

PMID	Title	Abstract
37707705	Effect of PLA2G6 and SMPD1 Variants on the Lipid Metabolism in the Cerebrospinal Fluid of Patients with Parkinson's Disease: A Non-targeted Lipidomics Study.	Exosome surface presence of melatomin receptor 1A (MTNR1A) was detectable only in patients with PLA2G6 mutations.