Protein detail
PGRC2
Membrane-associated progesterone receptor component 2 (Progesterone membrane-binding protein) (Steroid receptor protein DG6)
Entry name PGRC2 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 1 | Protein classification Predicted intracellular proteinsPredicted membrane proteinsPredicted secreted proteinsTransporters |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Membrane-associated progesterone receptor component 2 (Progesterone membrane-binding protein) (Steroid receptor protein DG6)
Protein Class
Predicted intracellular proteinsPredicted membrane proteinsPredicted secreted proteinsTransporters
Protein Function
- Predicted secreted proteins
- Transporters
- Predicted intracellular proteins
Transmembrane
42..66; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
DG6PMBP
Gene Description
Progesterone receptor membrane component 2
Chromosome
4
Position
128269237-128288829
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue SpecificretinaCell SpecificAdrenal medulla cellsSecretome LocationIntracellular and membraneSecretome FunctionOther
Function & Pathway
Protein Function
- Predicted secreted proteins
- Transporters
- Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Reactome
- R-hsa-8953897 cellular responses to stimuli
- R-hsa-9707616 heme signaling
- R-hsa-9013404 rac2 gtpase cycle
- R-hsa-9013423 rac3 gtpase cycle
- R-hsa-8980692 rhoa gtpase cycle
- R-hsa-9013405 rhod gtpase cycle
- R-hsa-9013408 rhog gtpase cycle
- R-hsa-9012999 rho gtpase cycle
- R-hsa-9716542 signaling by rho gtpases miro gtpases and rhobtb3
Mediation Categories
Fusion and delivery mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
17 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | Ramilowski_location | No | No | Yes | No | No |
| transmembrane | transmembrane | OmniPath | No | No | Yes | No | No |
| secreted | secreted | UniProt_keyword | No | No | Yes | No | No |
| secreted | secreted | UniProt_location | No | No | Yes | No | No |
| secreted | secreted | OmniPath | No | No | Yes | No | No |
| receptor | receptor | CellCellInteractions | No | Yes | Yes | No | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | Yes | No | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
2 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| CANXDDOSTJAGN1MAGT1PGRMC2RPN1SEC61A1SEC63 | O15173P04843P27824P39656P61619Q8N5M9Q9H0U3Q9UGP8 | 0:0:0:0:0:0:0:0 | hu.MAP2 | |||
| DDOSTJAGN1MAGT1PGRMC2RPN1SEC61A1SEC63 | O15173P04843P39656P61619Q8N5M9Q9H0U3Q9UGP8 | 0:0:0:0:0:0:0 | hu.MAP2 |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Size Exclusion Chromatography | Mass SpectrometryElisa | 1 | 38071653 |
Sequence, Structure & Domains
Sequences
Length
223
Mass
23,818
Sequence
MAAGDGDVKLGTLGSGSESSNDGGSESPGDAGAAAEGGGWAAAALALLTGGGEMLLNVALVALVLLGAYRLWVRWGRRGLGAGAGAGEESPATSLPRMKKRDFSLEQLRQYDGSRNPRILLAVNGKVFDVTKGSKFYGPAGPYGIFAGRDASRGLATFCLDKDALRDEYDDLSDLNAVQMESVREWEMQFKEKYDYVGRLLKPGEEPSEYTDEEDTKDHNKQD
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O15173-1; Sequence=Displayed; Name=2; IsoId=O15173-2; Sequence=VSP_053500
Alternative Sequence
1; M -> MGGAGRGVGEGRGRGGGGRRWRAVM (in isoform 2)
3D Structural Models
Domain & Motif Annotations
Compositional Bias
15..33; Low complexity; 206..215; Acidic residues
Domain (CC)
The cytochrome b5 heme-binding domain lacks the conserved iron-binding His residues at positions 137 and 161..
Domain (FT)
102..201; Cytochrome b5 heme-binding
Region
1..33; Disordered; 202..223; Disordered
Protein Families
- Cytochrome b5 family
- MAPR subfamily
Sequence Similarities
Belongs to the cytochrome b5 family. MAPR subfamily.
Clinical Relevance
Interaction Protein
ENSG00000101193ENSG00000101558ENSG00000101856ENSG00000106803ENSG00000118705ENSG00000121073ENSG00000124783ENSG00000147324ENSG00000148841ENSG00000163902ENSG00000182544ENSG00000185825
Interaction Count
12
Interaction Dataset
intact_biogridintact_biogrid_opencellbiogrid_opencell