Protein detail

SPTC2

Serine palmitoyltransferase 2 (EC 2.3.1.50) (Long chain base biosynthesis protein 2) (LCB 2) (Long chain base biosynthesis protein 2a) (LCB2a) (Serine-palmitoyl-CoA transferase 2) (SPT 2)

Protein symbol SPTC2	UniProt ID O15270	EVMP score 0.50
Frequency 2	Transmembrane count 1	Protein classification

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Serine palmitoyltransferase 2 (EC 2.3.1.50) (Long chain base biosynthesis protein 2) (LCB 2) (Long chain base biosynthesis protein 2a) (LCB2a) (Serine-palmitoyl-CoA transferase 2) (SPT 2)

Protein Function

Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
ENZYME proteins:Transferases
Potential drug targets
Enzymes
Disease related genes

Transmembrane

67..87; Helical

Transmembrane Count

Ensembl

ENSG00000100596

Entrez Gene Symbol

SPTLC2

Frequency

EVMP Score

0.50

Fluorescence & Localization

Function & Pathway

Protein Function

Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
ENZYME proteins:Transferases
Potential drug targets
Enzymes
Disease related genes

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Mediation Categories

Metabolism mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

14 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	OmniPath	No	Yes	No	No	No
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
transmembrane	transmembrane	UniProt_location	No	No	No	No	No
transmembrane	transmembrane	UniProt_topology	No	No	No	No	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	No	No
transmembrane	transmembrane	LOCATE	No	No	No	No	No

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Regulatory Interaction Network

0 records.

Protein Complex Composition

10 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
Serine-palmitoyltransferase (SPTLC1SPTLC2) complex	SPTLC1 SPTLC2	O15269 O15270	0:0	CORUMhu.MAPhu.MAP2	CORUM:6968	17023427
Serine-palmitoyltransferase (SPTLC1SPTLC2SPTLC3) complex	SPTLC1 SPTLC2 SPTLC3	O15269 O15270 Q9NUV7	1:1:1	CompleatCORUM	Compleat:HC759CORUM:6969	17331073 8058731
Serine-palmitoyltransferase (SPTLC1SPTLC2ssSPTa) complex	SPTLC1 SPTLC2 SPTSSA	O15269 O15270 Q969W0	2:2:2	CORUMComplexPortalPDB	PDB:7K0IPDB:7k0lintact:EBI-26964783PDB:7k0iCORUM:6974PDB:7k0jPDB:7k0k	19416851 14755292 33558761
Serine-palmitoyltransferase (SPTLC1SPTLC2ssSPTb) complex	SPTLC1 SPTLC2 SPTSSB	O15269 O15270 Q8NFR3	2:2:2	CORUMComplexPortal	intact:EBI-26967735CORUM:6973	19416851 14755292 33558761
serine C-palmitoyltransferase complex	SPTLC1 SPTLC2 SPTLC3 SPTSSA SPTSSB	O15269 O15270 Q8NFR3 Q969W0 Q9NUV7	1:1:1:1:1	Compleat	Compleat:HC1101	17331073 19416851
	HSPA1L ORMDL3 PIGO SPTLC1 SPTLC2 UBC	O15269 O15270 P0CG48 P34931 Q8N138 Q8TEQ8	1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC9359
	ORMDL3 PIGF PIGO SPTLC1 SPTLC2 UBC	O15269 O15270 P0CG48 Q07326 Q8N138 Q8TEQ8	1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC5296
	ORMDL2 ORMDL3 PIGO SPTLC1 SPTLC2 UBC	O15269 O15270 P0CG48 Q53FV1 Q8N138 Q8TEQ8	1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC4708
	ORMDL1 ORMDL3 PIGO SPTLC1 SPTLC2 UBC	O15269 O15270 P0CG48 Q8N138 Q8TEQ8 Q9P0S3	1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC7774
	ORMDL3 SPTLC1 SPTLC2 SPTSSA	O15269 O15270 Q8N138 Q969W0	2:2:2:2	PDB	PDB:7k0mPDB:7cqkPDB:7k0pPDB:7k0qPDB:7yiuPDB:6m4oPDB:7cqiPDB:7k0oPDB:7yj1PDB:7yj2PDB:7yiyPDB:6m4nPDB:7k0n

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	1	40689422

Sequence, Structure & Domains

Sequences

Length

562

Mass

62,924

Sequence

MRPEPGGCCCRRTVRANGCVANGEVRNGYVRSSAAAAAAAAAGQIHHVTQNGGLYKRPFNEAFEETPMLVAVLTYVGYGVLTLFGYLRDFLRYWRIEKCHHATEREEQKDFVSLYQDFENFYTRNLYMRIRDNWNRPICSVPGARVDIMERQSHDYNWSFKYTGNIIKGVINMGSYNYLGFARNTGSCQEAAAKVLEEYGAGVCSTRQEIGNLDKHEELEELVARFLGVEAAMAYGMGFATNSMNIPALVGKGCLILSDELNHASLVLGARLSGATIRIFKHNNMQSLEKLLKDAIVYGQPRTRRPWKKILILVEGIYSMEGSIVRLPEVIALKKKYKAYLYLDEAHSIGALGPTGRGVVEYFGLDPEDVDVMMGTFTKSFGASGGYIGGKKELIDYLRTHSHSAVYATSLSPPVVEQIITSMKCIMGQDGTSLGKECVQQLAENTRYFRRRLKEMGFIIYGNEDSPVVPLMLYMPAKIGAFGREMLKRNIGVVVVGFPATPIIESRARFCLSAAHTKEILDTALKEIDEVGDLLQLKYSRHRLVPLLDRPFDETTYEETED

3D Structural Models

Turn

92..94; 117..120; 207..210; 301..303; 319..322; 346..351; 428..430; 455..457; 498..500; 503..505

Helix

68..91; 106..108; 121..125; 127..129; 131..133; 178..180; 187..198; 214..227; 238..243; 246..248; 264..273; 285..298; 327..336; 358..362; 367..369; 392..401; 403..407; 413..427; 434..454; 476..488; 518..535

Beta Strand

50..52; 54..57; 100..102; 109..111; 137..140; 143..152; 154..159; 161..172; 184..186; 204..206; 229..234; 254..259; 276..280; 308..318; 340..344; 352..356; 371..383; 386..390; 431..433; 467..472; 494..496; 507..511; 513..515

3D Structure

Electron microscopy (17)

Domain & Motif Annotations

Protein Families

Class-II pyridoxal-phosphate-dependent aminotransferase family

Sequence Similarities

Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

Clinical Relevance

Interaction Protein

ENSG00000054356ENSG00000090054

Interaction Count

Interaction Dataset

biogrid_bioplexintact_biogrid_opencell