Protein detail

SPTC2

Serine palmitoyltransferase 2 (EC 2.3.1.50) (Long chain base biosynthesis protein 2) (LCB 2) (Long chain base biosynthesis protein 2a) (LCB2a) (Serine-palmitoyl-CoA transferase 2) (SPT 2)

Entry name SPTC2	UniProt ID O15270	EVMP confidence score 0.50
Supporting publications (n) 2	Transmembrane count 1	Protein classification

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information8

Protein Names

Serine palmitoyltransferase 2 (EC 2.3.1.50) (Long chain base biosynthesis protein 2) (LCB 2) (Long chain base biosynthesis protein 2a) (LCB2a) (Serine-palmitoyl-CoA transferase 2) (SPT 2)

Protein Function (5)

Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
ENZYME proteins:Transferases
Potential drug targets
Enzymes
Disease related genes

Transmembrane

67..87; Helical

Transmembrane Count

Ensembl

ENSG00000100596

Entrez Gene Symbol

SPTLC2

Supporting publications (n)

EVMP confidence score

0.50

Function & Pathway7

Protein Function (5)

Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
ENZYME proteins:Transferases
Potential drug targets
Enzymes
Disease related genes

Cellular Component (2)

Molecular Function (3)

Biological Process (3)

KEGG (4)

Reactome (3)

Mediation Categories

Metabolism mediation

Relations & Evidence25

Ligand-Receptor Signaling (14)

14 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane	transmembrane	Ramilowski_location	No	No	No	No	No
transmembrane	transmembrane	OmniPath	No	No	No	No	No
receptor	receptor	scConnect	No	Yes	No	No	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	No	No

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Protein Complex Composition (10)

10 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
Serine-palmitoyltransferase (SPTLC1SPTLC2) complex	SPTLC1 SPTLC2	O15269 O15270	0:0	CORUMhu.MAPhu.MAP2	CORUM:6968	17023427
Serine-palmitoyltransferase (SPTLC1SPTLC2SPTLC3) complex	SPTLC1 SPTLC2 SPTLC3	O15269 O15270 Q9NUV7	1:1:1	CompleatCORUM	Compleat:HC759CORUM:6969	17331073 8058731
Serine-palmitoyltransferase (SPTLC1SPTLC2ssSPTa) complex	SPTLC1 SPTLC2 SPTSSA	O15269 O15270 Q969W0	2:2:2	CORUMComplexPortalPDB	PDB:7K0IPDB:7k0lintact:EBI-26964783PDB:7k0iCORUM:6974PDB:7k0jPDB:7k0k	19416851 14755292 33558761
Serine-palmitoyltransferase (SPTLC1SPTLC2ssSPTb) complex	SPTLC1 SPTLC2 SPTSSB	O15269 O15270 Q8NFR3	2:2:2	CORUMComplexPortal	intact:EBI-26967735CORUM:6973	19416851 14755292 33558761
serine C-palmitoyltransferase complex	SPTLC1 SPTLC2 SPTLC3 SPTSSA SPTSSB	O15269 O15270 Q8NFR3 Q969W0 Q9NUV7	1:1:1:1:1	Compleat	Compleat:HC1101	17331073 19416851
	HSPA1L ORMDL3 PIGO SPTLC1 SPTLC2 UBC	O15269 O15270 P0CG48 P34931 Q8N138 Q8TEQ8	1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC9359
	ORMDL3 PIGF PIGO SPTLC1 SPTLC2 UBC	O15269 O15270 P0CG48 Q07326 Q8N138 Q8TEQ8	1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC5296
	ORMDL2 ORMDL3 PIGO SPTLC1 SPTLC2 UBC	O15269 O15270 P0CG48 Q53FV1 Q8N138 Q8TEQ8	1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC4708
	ORMDL1 ORMDL3 PIGO SPTLC1 SPTLC2 UBC	O15269 O15270 P0CG48 Q8N138 Q8TEQ8 Q9P0S3	1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC7774
	ORMDL3 SPTLC1 SPTLC2 SPTSSA	O15269 O15270 Q8N138 Q969W0	2:2:2:2	PDB	PDB:7k0mPDB:7cqkPDB:7k0pPDB:7k0qPDB:7yiuPDB:6m4oPDB:7cqiPDB:7k0oPDB:7yj1PDB:7yj2PDB:7yiyPDB:6m4nPDB:7k0n

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	1	40689422

Sequence, Structure & Domains9

Sequences

Length

562

Mass

62,924

Sequence

MRPEPGGCCCRRTVRANGCVANGEVRNGYVRSSAAAAAAAAAGQIHHVTQNGGLYKRPFNEAFEETPMLVAVLTYVGYGVLTLFGYLRDFLRYWRIEKCHHATEREEQKDFVSLYQDFENFYTRNLYMRIRDNWNRPICSVPGARVDIMERQSHDYNWSFKYTGNIIKGVINMGSYNYLGFARNTGSCQEAAAKVLEEYGAGVCSTRQEIGNLDKHEELEELVARFLGVEAAMAYGMGFATNSMNIPALVGKGCLILSDELNHASLVLGARLSGATIRIFKHNNMQSLEKLLKDAIVYGQPRTRRPWKKILILVEGIYSMEGSIVRLPEVIALKKKYKAYLYLDEAHSIGALGPTGRGVVEYFGLDPEDVDVMMGTFTKSFGASGGYIGGKKELIDYLRTHSHSAVYATSLSPPVVEQIITSMKCIMGQDGTSLGKECVQQLAENTRYFRRRLKEMGFIIYGNEDSPVVPLMLYMPAKIGAFGREMLKRNIGVVVVGFPATPIIESRARFCLSAAHTKEILDTALKEIDEVGDLLQLKYSRHRLVPLLDRPFDETTYEETED

3D Structural Models

Turn

92..94; 117..120; 207..210; 301..303; 319..322; 346..351; 428..430; 455..457; 498..500; 503..505

Helix

68..91; 106..108; 121..125; 127..129; 131..133; 178..180; 187..198; 214..227; 238..243; 246..248; 264..273; 285..298; 327..336; 358..362; 367..369; 392..401; 403..407; 413..427; 434..454; 476..488; 518..535

Beta Strand

50..52; 54..57; 100..102; 109..111; 137..140; 143..152; 154..159; 161..172; 184..186; 204..206; 229..234; 254..259; 276..280; 308..318; 340..344; 352..356; 371..383; 386..390; 431..433; 467..472; 494..496; 507..511; 513..515

3D Structure

Electron microscopy (17)

Domain & Motif Annotations

Protein Families

Class-II pyridoxal-phosphate-dependent aminotransferase family

Sequence Similarities

Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

Clinical Relevance3

Interaction Protein (2)

ENSG00000054356ENSG00000090054

Interaction Count

Interaction Dataset (2)

biogrid_bioplexintact_biogrid_opencell

Supporting Publications2

PMID	Title	Abstract
33709510	Unbiased proteomic profiling of host cell extracellular vesicle composition and dynamics upon HIV-1 infection.	No abstract available
38731868	The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer.	No abstract available