Protein detail

ARPC5

Actin-related protein 2/3 complex subunit 5 (Arp2/3 complex 16 kDa subunit) (p16-ARC)

Entry name
ARPC5
UniProt ID
O15511
EVMP confidence score
0.88
Supporting publications (n)
28
Transmembrane count
Protein classification
Plasma proteinsPredicted intracellular proteins
Basic Information
Protein Names
Actin-related protein 2/3 complex subunit 5 (Arp2/3 complex 16 kDa subunit) (p16-ARC)
Protein Class (2)
Plasma proteinsPredicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
ENSG00000162704
Entrez Gene Symbol
ARPC5
Gene Synonym (3)
ARC16dJ127C7.3p16-Arc
Gene Description
Actin related protein 2/3 complex subunit 5
Chromosome
1
Position
183620846-183635783
Supporting publications (n)
28
EVMP confidence score
0.88
Fluorescence & Localization
ARPC5 fluorescence
Cell SpecificEsophageal basal cellsSingle-Nuclei Brain Specificleukocyte
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component (12)
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Molecular Function (3)
Biological Process (3)
KEGG (11)
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Reactome (15)
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Mediation Categories (5)
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence31

Enzyme-Mediated Modification (2)

2 records.

Substrate Gene SymbolEnzyme Gene SymbolEnzyme UniProt IDResidue TypeResidue OffsetModificationDatabaseReferences
ARPC5MAPKAPK2P49137S77phosphorylationSparser_ProtMapperSIGNORProtMapperHPRDKEASIGNOR_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapperProtMapper:18725535KEA:12829704ProtMapper:12829704ProtMapper:22792454HPRD:20068231HPRD:12829704SIGNOR:12829704
ARPC5MAPKAPK2P49137S80phosphorylationMIMPHPRD_MIMPPhosphoSite_MIMP

Ligand-Receptor Signaling (9)

9 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
ecmecmMatrixDBYes
ecmecmGO_IntercellYes
ecmecmOmniPathYes
intracellularintracellularComPPI
intracellularintracellularGO_Intercell
intracellularintracellularUniProt_location
intracellularintracellularOmniPath
ligandligandCellTalkDBYes
ligandligandOmniPathYes

Regulatory Interaction Network (1)

1 record.

Source Protein SymbolSource UniProt IDTarget Protein SymbolTarget UniProt IDIs DirectedIs StimulationIs InhibitionDatabaseReferences
MAPK2P49137ARPC5O15511YesYesWangSparser_ProtMapperPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperREACH_ProtMapperHPRDPhosphoSite_KEAKEAHPRD_KEASIGNOR_ProtMapperPhosphoSiteHPRD-phosPhosphoSite_ProtMapperProtMapper:18725535KEA:12829704ProtMapper:12829704ProtMapper:22792454HPRD:12829704ProtMapper:20068231HPRD-phos:20068231SIGNOR:12829704PhosphoSite:12829704HPRD-phos:12829704

Protein Complex Composition (18)

18 records.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
ARP2/3ACTR2ACTR3ARPC1AARPC2ARPC3ARPC4ARPC5O15144O15145O15511P59998P61158P61160Q927471:1:1:1:1:1:1SIGNORComplexPortalPDBPDB:6yw7SIGNOR:SIGNOR-C146266558343266113114755292
Actin-related protein 2/3 complexARPC1A-ACTR3-ARPC5L variantACTR2ACTR3ARPC1AARPC2ARPC3ARPC4ARPC5LO15144O15145P59998P61158P61160Q92747Q9BPX51:1:1:1:1:1:1ComplexPortal266558343266113114755292
Actin-related protein 2/3 complexARPC1A-ACTR3B-ARPC5 variantACTR2ACTR3BARPC1AARPC2ARPC3ARPC4ARPC5O15144O15145O15511P59998P61160Q92747Q9P1U11:1:1:1:1:1:1ComplexPortal266558343266113114755292
Actin-related protein 2/3 complexARPC1B-ACTR3-ARPC5L variantACTR2ACTR3ARPC1BARPC2ARPC3ARPC4ARPC5LO15143O15144O15145P59998P61158P61160Q9BPX51:1:1:1:1:1:1ComplexPortalPDBintact:EBI-9022767PDB:6yw6PDB:6YW6266558343266113114755292
Actin-related protein 2/3 complexARPC1B-ACTR3B-ARPC5 variantACTR2ACTR3BARPC1BARPC2ARPC3ARPC4ARPC5O15143O15144O15145O15511P59998P61160Q9P1U11:1:1:1:1:1:1ComplexPortal266558343266113114755292
Actin-related protein 2/3 complexARPC1B-ACTR3B-ARPC5L variantACTR2ACTR3BARPC1BARPC2ARPC3ARPC4ARPC5LO15143O15144O15145P59998P61160Q9BPX5Q9P1U11:1:1:1:1:1:1ComplexPortal266558343266113114755292
Actin-related protein 2/3 complexARPC1B-ACTR3B-ARPC5L variantACTR2ACTR3BARPC1AARPC2ARPC3ARPC4ARPC5LO15144O15145P59998P61160Q92747Q9BPX5Q9P1U11:1:1:1:1:1:1ComplexPortal266558343266113114755292
Arp2/3 protein complexACTR2ACTR3ARPC1BARPC2ARPC3ARPC4ARPC5O15143O15144O15145O15511P59998P61158P611601:1:1:1:1:1:1CORUMCompleatComplexPortalCompleat:HC1939CORUM:272665583432661131147552929359840
Arp2/3 protein complexACTR2ACTR3ACTR3BACTR3CARPC1AARPC1BARPC2ARPC3ARPC4ARPC5ARPC5LO15143O15144O15145O15511P59998P61158P61160Q92747Q9BPX5Q9C0K3Q9P1U11:1:1:1:1:1:1:1:1:1:1CompleatCompleat:HC267510377407
ACTL8ACTR2ACTR3ACTR3BARPC1AARPC1BARPC2ARPC3ARPC4ARPC5RRM1RRM2RRM2BUBCO15143O15144O15145O15511P0CG48P23921P31350P59998P61158P61160Q7LG56Q92747Q9H568Q9P1U11:1:1:1:1:1:1:1:1:1:1:1:1:1NetworkBlastCompleatCompleat:HC8882
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Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationMass spectrometry137713494
Sequence, Structure & Domains

Sequences

Length
151
Mass
16,320
Sequence
MSKNTVSSARFRKVDVDEYDENKFVDEEDGGDGQAGPDEGEVDSCLRQGNMTAALQAALKNPPINTKSQAVKDRAGSIVLKVLISFKANDIEKAVQSLDKNGVDLLMKYIYKGFESPSDNSSAMLLQWHEKALAAGGVGSIVRVLTARKTV
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O15511-1; Sequence=Displayed; Name=2; IsoId=O15511-2; Sequence=VSP_024028
Alternative Sequence
48; Q -> HSIT (in isoform 2)

3D Structural Models

3D Structure
Electron microscopy (2)

Domain & Motif Annotations

Region
21..44; Disordered
Protein Families
ARPC5 family
Sequence Similarities
Belongs to the ARPC5 family.
Clinical Relevance
Disease Involvement
Disease variant
Antibody (2)
HPA022013HPA031972
Interaction Protein (10)
ENSG00000070831ENSG00000077549ENSG00000111229ENSG00000115091ENSG00000130429ENSG00000133627ENSG00000138071ENSG00000163466ENSG00000241553ENSG00000241685
Interaction Count
10
Interaction Dataset (5)
biogrid_opencellbiogrid_opencell_bioplexbiogrid_bioplexintact_biogridintact_biogrid_bioplex
Supporting Publications28
PMIDTitleRelated sentences
38207106Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity.No related sentences available
39001700Optimized AF4 combined with density cushion ultracentrifugation enables profiling of high-purity human blood extracellular vesicles.No related sentences available
39207047The trajectory of vesicular proteomic signatures from HBV-HCC by chitosan-magnetic bead-based separation and DIA-proteomic analysis.No related sentences available
40189497Small extracellular vesicle-based one-step high-throughput microfluidic platform for epithelial ovarian cancer diagnosis.No related sentences available
40465195Extracellular vesicle proteomics uncovers energy metabolism, complement system, and endoplasmic reticulum stress response dysregulation postexercise in males with myalgic encephalomyelitis/chronic fatigue syndrome.No related sentences available
40840701Multiomics analysis to evaluate the enrichment of extracellular vesicles from human plasma.No related sentences available
41068253Identification of plasma extracellular vesicle protein biomarkers in diabetic retinopathy progression.No related sentences available
41307968Extracellular Vesicles Define Discrete Nano-Based Niches Within the Human Haematopoietic System.No related sentences available
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