Protein detail
ASAP2
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 (Development and differentiation-enhancing factor 2) (Paxillin-associated protein with ARF GAP activity 3) (PAG3) (Pyk2 C-terminus-associated protein) (PAP)
Protein symbol ASAP2 | UniProt ID | EVMP score 0.60 |
Frequency 12 | Transmembrane count | Protein classification Predicted intracellular proteins |
Basic Information
Protein Names
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 (Development and differentiation-enhancing factor 2) (Paxillin-associated protein with ARF GAP activity 3) (PAG3) (Pyk2 C-terminus-associated protein) (PAP)
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
CENTB3DDEF2KIAA0400PAPSHAG1
Gene Description
ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
Chromosome
2
Position
9206765-9405683
Frequency
12
EVMP Score
0.60
Fluorescence & Localization
Tissue SpecificintestineCell SpecificAstrocytes
Function & Pathway
Protein Function
Predicted intracellular proteins
Molecular Function
Biological Process
Mediation Categories
Receptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
4 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| ASAP2 | SIK1 | P57059 | S | 701 | phosphorylation | PhosphoNetworks | |
| ASAP2 | PRKACA | P17612 | S | 822 | phosphorylation | PhosphoNetworks | |
| ASAP2 | RPS6KB1 | P23443 | S | 822 | phosphorylation | PhosphoNetworks | |
| ASAP2 | SRPK2 | P78362 | S | 822 | phosphorylation | PhosphoNetworks |
Ligand-Receptor Signaling
7 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
4 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| ASAP2 | O43150 | ARF5 | P84085 | Yes | Yes | No | HPRDSIGNOR | SIGNOR:10022920HPRD:10749932HPRD:10022920 |
| ASAP2 | O43150 | ARF1 | P84077 | Yes | Yes | Yes | HPRDWangSIGNORAdhesome | HPRD:10749932Adhesome:11304556Adhesome:10022920SIGNOR:10022920HPRD:10022920Adhesome:10749932 |
| FAK2 | Q14289 | ASAP2 | O43150 | Yes | Yes | No | AdhesomePhosphoPointSIGNORHPRDWang | SIGNOR:10022920HPRD:10022920Adhesome:10022920 |
| ASAP2 | O43150 | ARF6 | P62330 | Yes | Yes | No | HPRDWangSIGNOR | SIGNOR:10022920HPRD:10749932HPRD:10022920 |
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 31718609 |
Sequence, Structure & Domains
Sequences
Length
1,006
Mass
111,651
Sequence
MPDQISVSEFVAETHEDYKAPTASSFTTRTAQCRNTVAAIEEALDVDRMVLYKMKKSVKAINSSGLAHVENEEQYTQALEKFGGNCVCRDDPDLGSAFLKFSVFTKELTALFKNLIQNMNNIISFPLDSLLKGDLKGVKGDLKKPFDKAWKDYETKITKIEKEKKEHAKLHGMIRTEISGAEIAEEMEKERRFFQLQMCEYLLKVNEIKIKKGVDLLQNLIKYFHAQCNFFQDGLKAVESLKPSIETLSTDLHTIKQAQDEERRQLIQLRDILKSALQVEQKEDSQIRQSTAYSLHQPQGNKEHGTERNGSLYKKSDGIRKVWQKRKCSVKNGFLTISHGTANRPPAKLNLLTCQVKTNPEEKKCFDLISHDRTYHFQAEDEQECQIWMSVLQNSKEEALNNAFKGDDNTGENNIVQELTKEIISEVQRMTGNDVCCDCGAPDPTWLSTNLGILTCIECSGIHRELGVHYSRMQSLTLDVLGTSELLLAKNIGNAGFNEIMECCLPAEDSVKPNPGSDMNARKDYITAKYIERRYARKKHADNAAKLHSLCEAVKTRDIFGLLQAYADGVDLTEKIPLANGHEPDETALHLAVRSVDRTSLHIVDFLVQNSGNLDKQTGKGSTALHYCCLTDNAECLKLLLRGKASIEIANESGETPLDIAKRLKHEHCEELLTQALSGRFNSHVHVEYEWRLLHEDLDESDDDMDEKLQPSPNRREDRPISFYQLGSNQLQSNAVSLARDAANLAKEKQRAFMPSILQNETYGALLSGSPPPAQPAAPSTTSAPPLPPRNVGKVQTASSANTLWKTNSVSVDGGSRQRSSSDPPAVHPPLPPLRVTSTNPLTPTPPPPVAKTPSVMEALSQPSKPAPPGISQIRPPPLPPQPPSRLPQKKPAPGADKSTPLTNKGQPRGPVDLSATEALGPLSNAMVLQPPAPMPRKSQATKLKPKRVKALYNCVADNPDELTFSEGDVIIVDGEEDQEWWIGHIDGDPGRKGAFPVSFVHFIAD
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=PAPalpha; IsoId=O43150-1; Sequence=Displayed; Name=2; Synonyms=PAPbeta; IsoId=O43150-2; Sequence=VSP_009722
Alternative Sequence
795..840; VQTASSANTLWKTNSVSVDGGSRQRSSSDPPAVHPPLPPLRVTSTN -> D (in isoform 2)
3D Structural Models
Domain & Motif Annotations
Compositional Bias
288..300; Polar residues; 794..823; Polar residues; 865..886; Pro residues
Repeat
584..616; ANK 1; 620..649; ANK 2
Coiled Coil
256..283; 729..752
Domain (CC)
The conserved Arg-464 in the Arf-GAP domain probably becomes part of the active site of bound small GTPases and is necessary for GTP hydrolysis.
Domain (FT)
305..397; PH; 421..543; Arf-GAP; 944..1006; SH3
Region
288..312; Disordered; 701..720; Disordered; 764..916; Disordered