Protein detail
ADA12
Disintegrin and metalloproteinase domain-containing protein 12 (ADAM 12) (EC 3.4.24.-) (Meltrin-alpha)
Protein symbol ADA12 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 1 | Protein classification Predicted membrane proteinsPredicted secreted proteinsTransporters |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Disintegrin and metalloproteinase domain-containing protein 12 (ADAM 12) (EC 3.4.24.-) (Meltrin-alpha)
Protein Class
Predicted membrane proteinsPredicted secreted proteinsTransporters
Protein Function
- Predicted secreted proteins
- Transporters:Accessory Factors Involved in Transport
Transmembrane
709..729; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
MCMPMltnaMLTN
Gene Description
ADAM metallopeptidase domain 12
Chromosome
10
Position
126012381-126388477
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Function & Pathway
Protein Function
- Predicted secreted proteins
- Transporters:Accessory Factors Involved in Transport
Molecular Function
Biological Process
Reactome
Mediation Categories
Receptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
38 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| adhesion | adhesion | OmniPath | Yes | Yes | Yes | Yes | No |
| cell_adhesion | cell_adhesion | OmniPath | Yes | Yes | Yes | Yes | No |
| cell_surface_enzyme | cell_surface_enzyme | Surfaceome | Yes | No | Yes | Yes | No |
| cell_surface_enzyme | cell_surface_enzyme | OmniPath | Yes | No | Yes | Yes | No |
| transmembrane | transmembrane | UniProt_location | No | No | Yes | Yes | No |
| transmembrane | transmembrane | UniProt_topology | No | No | Yes | Yes | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | Yes | Yes | No |
| transmembrane_predicted | transmembrane | OmniPath | No | No | Yes | Yes | No |
| transmembrane | transmembrane | LOCATE | No | No | Yes | Yes | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | Yes | Yes | No |
Regulatory Interaction Network
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| ADA12 | O43184 | SDC4 | P31431 | Yes | Yes | No | Fantom5_LRdbCellTalkDBHPMR_LRdbiTALKAdhesometalklrRamilowski2015SIGNORconnectomeDB2020WangLRdbSTRING_talklrEMBRACEHPMR_talklr | Adhesome:12509413connectomeDB2020:12509413CellTalkDB:12509413SIGNOR:12509413LRdb:12509413 |
Protein Complex Composition
0 records.
Sequence, Structure & Domains
Sequences
Length
909
Mass
99,542
Sequence
MAARPLPVSPARALLLALAGALLAPCEARGVSLWNQGRADEVVSASVGSGDLWIPVKSFDSKNHPEVLNIRLQRESKELIINLERNEGLIASSFTETHYLQDGTDVSLARNYTVILGHCYYHGHVRGYSDSAVSLSTCSGLRGLIVFENESYVLEPMKSATNRYKLFPAKKLKSVRGSCGSHHNTPNLAAKNVFPPPSQTWARRHKRETLKATKYVELVIVADNREFQRQGKDLEKVKQRLIEIANHVDKFYRPLNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMKLLPRKSHDNAQLVSGVYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLAHELGHNFGMNHDTLDRGCSCQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGMGVCLFNLPEVRESFGGQKCGNRFVEEGEECDCGEPEECMNRCCNATTCTLKPDAVCAHGLCCEDCQLKPAGTACRDSSNSCDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGICQTHEQQCVTLWGPGAKPAPGICFERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQCQGGASRPVIGTNAVSIETNIPLQQGGRILCRGTHVYLGDDMPDPGLVLAGTKCADGKICLNRQCQNISVFGVHECAMQCHGRGVCNNRKNCHCEAHWAPPFCDKFGFGGSTDSGPIRQADNQGLTIGILVTILCLLAAGFVVYLKRKTLIRLLFTNKKTTIEKLRCVRPSRPPRGFQPCQAHLGHLGKGLMRKPPDSYPPKDNPRRLLQCQNVDISRPLNGLNVPQPQSTQRVLPPLHRAPRAPSVPARPLPAKPALRQAQGTCKPNPPQKPLPADPLARTTRLTHALARTPGQWETGLRLAPLRPAPQYPHQVPRSTHTAYIK
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=12L; IsoId=O43184-1; Sequence=Displayed; Name=2; Synonyms=12S; IsoId=O43184-2; Sequence=VSP_005476, VSP_005477; Name=3; IsoId=O43184-3; Sequence=VSP_031001, VSP_005476, VSP_005477; Name=4; IsoId=O43184-4; Sequence=VSP_031001, VSP_031002, VSP_031003
Alternative Sequence
114..116; Missing (in isoform 3 and isoform 4); 705..740; DNQGLTIGILVTILCLLAAGFVVYLKRKTLIRLLFT -> GKEARQEAAESNRERGQGQEPVGSQEHASTASLTLI (in isoform 4); 705..738; DNQGLTIGILVTILCLLAAGFVVYLKRKTLIRLL -> EARQEAAESNRERGQGQEPVGSQEHASTASLTLI (in isoform 2 and isoform 3); 739..909; Missing (in isoform 2 and isoform 3); 741..909; Missing (in isoform 4)
3D Structural Models
Domain & Motif Annotations
Compositional Bias
851..860; Pro residues
Motif
177..184; Cysteine switch; 828..834; SH3-binding; class II; 834..841; SH3-binding; class I; 885..891; SH3-binding; class I
Domain (CC)
The cysteine-rich domain supports cell adhesion through syndecans and triggers signaling events that lead to beta-1 integrin-dependent cell spreading. In carcinomas cells the binding of this domain to syndecans does not allow the integrin-mediated cell spreading.; DOMAIN: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Domain (FT)
214..416; Peptidase M12B; 424..510; Disintegrin; 656..688; EGF-like
Region
822..862; Disordered